ID A0A093BYP0_9AVES Unreviewed; 2840 AA.
AC A0A093BYP0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Adenomatous polyposis coli protein {ECO:0000313|EMBL:KFV05964.1};
DE Flags: Fragment;
GN ORFNames=N339_11901 {ECO:0000313|EMBL:KFV05964.1};
OS Pterocles gutturalis (yellow-throated sandgrouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Ciconiiformes; Pteroclidae; Pterocles.
OX NCBI_TaxID=240206 {ECO:0000313|EMBL:KFV05964.1, ECO:0000313|Proteomes:UP000053149};
RN [1] {ECO:0000313|EMBL:KFV05964.1, ECO:0000313|Proteomes:UP000053149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N339 {ECO:0000313|EMBL:KFV05964.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the adenomatous polyposis coli (APC) family.
CC {ECO:0000256|ARBA:ARBA00009051}.
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DR EMBL; KL231384; KFV05964.1; -; Genomic_DNA.
DR Proteomes; UP000053149; Unassembled WGS sequence.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0008013; F:beta-catenin binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.10; -; 1.
DR Gene3D; 1.10.287.450; Helix hairpin bin; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR009240; APC_15aa_rpt.
DR InterPro; IPR009234; APC_basic_dom.
DR InterPro; IPR026831; APC_dom.
DR InterPro; IPR026818; Apc_fam.
DR InterPro; IPR032038; APC_N.
DR InterPro; IPR036149; APC_N_sf.
DR InterPro; IPR041257; APC_rep.
DR InterPro; IPR009223; APC_rpt.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR009232; EB1-bd.
DR InterPro; IPR009224; SAMP.
DR PANTHER; PTHR12607:SF11; ADENOMATOUS POLYPOSIS COLI PROTEIN; 1.
DR PANTHER; PTHR12607; ADENOMATOUS POLYPOSIS COLI PROTEIN FAMILY; 1.
DR Pfam; PF05972; APC_15aa; 3.
DR Pfam; PF05956; APC_basic; 1.
DR Pfam; PF16689; APC_N_CC; 1.
DR Pfam; PF05923; APC_r; 7.
DR Pfam; PF18797; APC_rep; 1.
DR Pfam; PF16634; APC_u13; 1.
DR Pfam; PF16635; APC_u14; 1.
DR Pfam; PF16636; APC_u15; 1.
DR Pfam; PF16630; APC_u5; 1.
DR Pfam; PF16633; APC_u9; 1.
DR Pfam; PF00514; Arm; 2.
DR Pfam; PF16629; Arm_APC_u3; 1.
DR Pfam; PF05937; EB1_binding; 1.
DR Pfam; PF05924; SAMP; 3.
DR Pfam; PF11414; Suppressor_APC; 1.
DR SMART; SM00185; ARM; 7.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF58050; N-terminal coiled coil domain from apc; 1.
DR SUPFAM; SSF82931; Tumor suppressor gene product Apc; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000053149};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 6..57
FT /note="Adenomatous polyposis coli N-terminal dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16689"
FT REPEAT 662..704
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT DOMAIN 2222..2573
FT /note="Adenomatous polyposis coli protein basic"
FT /evidence="ECO:0000259|Pfam:PF05956"
FT DOMAIN 2669..2840
FT /note="EB-1 binding"
FT /evidence="ECO:0000259|Pfam:PF05937"
FT REGION 100..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 241..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 835..862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 925..993
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1038..1165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1188..1257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1315..1383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1410..1476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1536..1576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1592..1647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1672..1852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1883..1940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1969..2011
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2043..2071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2145..2187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2203..2637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2663..2840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 8..56
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 136..170
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 246..264
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..297
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 847..862
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 932..954
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 963..980
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1038..1054
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1055..1070
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1098..1135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1136..1165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1189..1257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1315..1381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1536..1568
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1623..1641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1688..1708
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1793..1838
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1883..1901
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1902..1934
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1993..2007
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2168..2187
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2203..2224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2232..2273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2285..2426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2461..2506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2517..2531
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2555..2578
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2622..2637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2668..2682
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2717..2738
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2745..2770
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2783..2810
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2820..2840
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV05964.1"
FT NON_TER 2840
FT /evidence="ECO:0000313|EMBL:KFV05964.1"
SQ SEQUENCE 2840 AA; 311385 MW; 9A095BF3541DD057 CRC64;
PRMAAASYDQ LLKQVEALKM ENSNLRQELE DNSNHLTKLE TEASNMKEVL KQLQGSIEDE
AMASSGQIDL LERLKELNLE STNFPGVKLR PKVSVRSYGS REGSVSSRSG ECSPVPMGSF
PRRGFMNGSR ESTGYLEELE KERSLLLAEL EKEEKEKDWY YAQLQNLTKR IDSLPLTENF
SLQTDMTRRQ LEYEARQIRA AMEEQLGTCQ DMEKRAQARV ARIQQIEKDI LRIRQLLQSQ
AAEAERAPQG KHDAGSHDTE RQNEGQGAAE ISMATSSTGQ GSAARMDHET ASVMSSSNNY
SVPRRLTSHL GTKVEMVYSL LSMLGTHDKD DMSRTLLAMS SSQDSCIAMR QSGCLPLLIQ
LLHGNDKDSV LLGNSRGSKE ARARASAALH NIIHSQPDDK RGRREIRVLH LLEQIRAYCE
TCWEWQEARE QGMDEDKNPM PAAVDHQICP AVCVLMKLSF DEEHRHAMNE LGGLQAIAEL
LQVDCEMYGL TNDHYSVTLR RYAGMALTNL TFGDVANKAT LCSMKGCMRA LVAQLKSESE
DLQQVIASVL RNLSWRADVN SKKTLREVGS VKALMECALE VKKESTLKSV LSALWNLSAH
CTENKADICA VDGALAFLVG TLTYRSQTNT LAIIESGGGI LRNVSSLIAT NEDHRQILRE
NSCLQTLLQH LKSHSLTIVS NACGTLWNLS ARNAKDQEAL WDMGAVSMLK NLIHSKHKMI
AMGSAAALRN LMANRPAKYK DANIMSPGSS LPSLLVRKQK ALEAELDAQH LSETFDNIDN
LSPKASHRNK QRHKQNIYSE YVLDSSRHDD GICRSESFNA GNMTVLSPYL NTTVLPGSSS
SSRGNVENSR SEKDRSLDRD RAVGLNTYHP TAENTGNSSK RTGMQISTAA AQIAKVIEEV
VSMHIPPEDR SSGSTSEMHC LTEDRNAPRR SATTHTHSNT YFPKSESSNR TCPVPYTKME
YKRASNDSLN SVSSSDGYGK RGQMKHSIES YSEDDESKFC SYGQYPADLA HKIHSANHMD
DNDGELDTPI NYSLKYSDEQ LNSGRQSPSQ NERWTRPKHI IDDEIKQNEQ RQSRSQNATY
PVYTESGDDK HLKYQSPFGQ QECVSSFRSR GSSGSDQNRV GSTIGINQKV NQSLCQVDDY
DDDKPTNYSE RYSEEEQHEE EDRPTNYSIK YNEEEHHVDQ PIDYSLKYST EVPPSSQKPS
FTFSKTSSVQ STKTDHISSS SGNTSALSAG SKRQNQLHPN SAQSRGGHAQ KSASCKTPSI
NQETIQTYCV EDTPICFSRC SSLSSLSSAE DEIGRDQSTR VTDVNNTLQI AELKENSGAL
STEGSVSEIT STSQHIRTKS SRLQTSSLSP SDSSRHKAVE FSSGAKSPSK SGAQTPKSPP
EHYVQETPLM FSRCTSVSSL DSFESRSIAS SVQSEPCSGM VSGIISPSDL PDSPGQTMPP
SRSKTPPPAQ GVQVKREVTK GKVPSAEKRE TGPRQAAVNA AVQRVQVLPD ADTLLHFATE
STPDGFSCSS SLSALSLDEP FIQKDVELRI MPPVHENEHG NETEPEQADD AKDNQEKQAE
KTTEAEKDIL DDSDDDDDIE ILEACIISAM PTKSSRKAKK PSQASAPKIP PPVARKPSQL
PVYKLLPSQS RLQSQKHVSF TPGDDTPRVY CVEGTPINFS TATSLSDLTI ESPPSELANI
DSVGTGAESG EFEKRDTIPT EGRSTDDSQR AKSSTVTHPG LDDDKTEEGD ILAECINSAM
PKGKSHKPFR VKKIMDQIQQ ASSSLSNKNQ PEGEKKKPTS PVKPVPQNNE YRTRIRKTTE
PKSSVNNERT YPENRHMKKQ NLKNNSRDFN DKLPNNEERV RGSFAFDSPH HYTPIEGTPY
CFSRNDSLSS LDFDDDDVDL SREKAELRKG KEAKETETKE CTNPEQSSNQ QPSNRTQVCQ
KHPTGRSLPK TFSQSAKDIP DRGAATDEKM QNFAIENTPV CFSRNSSLSS LSDIDQENNN
NKEGEPAKCS EAPDSQMESN RPQTSGYAPK SFHVEDTPVC FSRNSSLSSL SIDSEDDLQC
ISSAMPKKKK PSRIKSESEK NNSRNTGGIL AEDLTLDLRE IQRPDSEHGF SPDSENFDWK
AIQEGANSIV SSLHQAAAAA SLSRQASSDS DSILSLKSGI SLGSPFHLTP DQEEKPFTSN
KGPRILKPGE KSTLESKKVE SESRGIKGGK KVYKSIITGK ARANSEVSSH LKQPQQTSVP
SISRGRTMIH IPGVRNSSSS TSPVSKKGPP LKNMNSKSPS EGQSLTSSPR GVKSSVKPEP
APVTRQPSGL NQSGSSKGPS RSGSRDSTPS RPQQQPLSRP LQSPGRNSIS PGRNGISPPN
KLSQLPRTSS PSTASTKSSS SGRMSYTSPG RQMSQQNLTK QTALPKSTSS IPRSESASKG
LNQALSSGGS NKKTELSRMS STKSSGSESD RSERPVLVRQ STFIKEAPSP TLRWKLEESA
SFESLSPSRP DSPTRSQLQT PVLSPSLPDM SLSTHSTAQT CGWRKLPPNL SPSVEYDGRP
AKRHDIARSH SESPSRLPIN RSGTWKREHS KHSSSLPRVS TWRRTGSSSS ILSASSESSE
KAKSEDEKQH GSSLSGLKQS KESQAPAKGT WRKIKENEIP QIVNDPQHSS SGATNGSDSK
ALIYQMAPAV SKTEDVWVRI EDCPINNPRS GRSPTGNTPP VIDSVSEKGG VSGKDSKEIQ
EKQTPGNGGV RTIGLENRLN SFFQIDSPDK KGTETKPPQN NPVPAPENNE STVSERAPFS
SSSSSKHSSP IGAVAARVTP FNYNPSCRKS SVDNSSARPS QIPTPVSNST KKRDSKSENP
DSSGTQSPKR HSGSYLVTSV
//
