ID A0A093BZ32_TAUER Unreviewed; 1041 AA.
AC A0A093BZ32;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 {ECO:0000313|EMBL:KFV07453.1};
DE Flags: Fragment;
GN ORFNames=N340_12846 {ECO:0000313|EMBL:KFV07453.1};
OS Tauraco erythrolophus (Red-crested turaco).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Musophagiformes; Musophagidae; Tauraco.
OX NCBI_TaxID=121530 {ECO:0000313|EMBL:KFV07453.1, ECO:0000313|Proteomes:UP000053661};
RN [1] {ECO:0000313|EMBL:KFV07453.1, ECO:0000313|Proteomes:UP000053661}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N340 {ECO:0000313|EMBL:KFV07453.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the potassium channel HCN family.
CC {ECO:0000256|ARBA:ARBA00006305}.
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DR EMBL; KL453504; KFV07453.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093BZ32; -.
DR Proteomes; UP000053661; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013621; Ion_trans_N.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45689; I[[H]] CHANNEL, ISOFORM E; 1.
DR PANTHER; PTHR45689:SF4; POTASSIUM_SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 4; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08412; Ion_trans_N; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 3: Inferred from homology;
KW cAMP {ECO:0000256|ARBA:ARBA00023149};
KW cAMP-binding {ECO:0000256|ARBA:ARBA00022566};
KW Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022566};
KW Reference proteome {ECO:0000313|Proteomes:UP000053661};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022461}.
FT TRANSMEM 97..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 429..544
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 644..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 690..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 855..930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 942..980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 694..729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 738..836
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..925
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 942..969
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV07453.1"
FT NON_TER 1041
FT /evidence="ECO:0000313|EMBL:KFV07453.1"
SQ SEQUENCE 1041 AA; 113696 MW; 9337E62B263B809A CRC64;
PAPPASPPEP QQQPPRACSS TSIKVEGGGG CDQITPDEEQ RLGQAGFMQR QFGAMLQPGV
NKFSLRMFGS QKAVEREQER VKSAGFWIIH PYSDFRFYWD LTMLLLMVGN LIIIPVGITF
FKDENTTPWI VFNVVSDTFF LIDLVLNFRT GIVVEDNTEI ILDPQRIKMK YLKSWFVVDF
ISSIPVDYIF LIVETRIDSE VYKTARALRI VRFTKILSLL RLLRLSRLIR YIHQWEEIFH
MTYDLASAVV RIVNLIGMML LLCHWDGCLQ FLVPMLQDFP DDCWVSLNRM VNDSWGKQYS
YALFKAMSHM LCIGYGQQAP VGMSDVWLTM LSMIVGATCY AMFIGHATAL IQSLDSSRRQ
YQEKYKQVEQ YMSFHKLPAD MRQRIHDYYE HRYQGKMFDE ESILGELSEP LREEIINFNC
RKLVASMPLF ANADPNFVTS MLTKLRFEVF QPGDYIIREG TIGKKMYFIQ HGVVSVLTKG
NKETKLADGS YFGEICLLTR GRRTASVRAD TYCRLYSLSV DNFNEVLEEY PMMRRAFETV
ALDRLDRIGK KNSILLHKVQ HDLNSGVFNY QENEIIQQIV QHDREMAHCA HNVQAATAAA
AAALTPHPRL PTAIFRPPVS VLGSLGQQSN QTPRQLKRLQ SLIPSTGPSA VGSPSSTPSQ
LHTPGAETPS SSSFHIQQLA GFSAAAGLGQ FQVGSPPGGS SQPGSSGMSS VGPSQFHQAP
SGSPLGTTQP MQQQPPPQPA LSSGGFGHFQ QATTSSPSTS LTQLSSNSPP SLLNQFQPTT
RPLQGGQLQQ LSGSGTLGGM NHFQPPPSSN SPSSSLSQLA QASGGPSSGL CQTHPSALGS
LTGTIAQLHQ ERPPFASMSP LQQSGVASPC YTPSGLSPPS QSPVATRTFQ CGPSGASGSH
GSLLLPQTAS PPPQILQSKS TPPVPPGRLN QDIKLISASQ PSLPQELAQT LSQSSSHSSR
ESVSSFSPFP GGGTGLLGKP YSSIPGRVTL PRQMSSGSLP HPLVFGASAA GAASLTAGGR
KESIVLTGDL EPVRSKLPSN L
//
