ID   A0A093C1E6_TAUER        Unreviewed;       505 AA.
AC   A0A093C1E6;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   22-FEB-2023, entry version 22.
DE   RecName: Full=GATOR complex protein NPRL3 {ECO:0000256|RuleBase:RU368069};
DE   AltName: Full=Nitrogen permease regulator 3-like protein {ECO:0000256|RuleBase:RU368069};
DE   Flags: Fragment;
GN   ORFNames=N340_13099 {ECO:0000313|EMBL:KFV06899.1};
OS   Tauraco erythrolophus (Red-crested turaco).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Musophagiformes; Musophagidae; Tauraco.
OX   NCBI_TaxID=121530 {ECO:0000313|EMBL:KFV06899.1, ECO:0000313|Proteomes:UP000053661};
RN   [1] {ECO:0000313|EMBL:KFV06899.1, ECO:0000313|Proteomes:UP000053661}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N340 {ECO:0000313|EMBL:KFV06899.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: As a component of the GATOR1 complex functions as an
CC       inhibitor of the amino acid-sensing branch of the TORC1 pathway.
CC       {ECO:0000256|RuleBase:RU368069}.
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|RuleBase:RU368069}.
CC   -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000256|ARBA:ARBA00010546,
CC       ECO:0000256|RuleBase:RU368069}.
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DR   EMBL; KL452691; KFV06899.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A093C1E6; -.
DR   Proteomes; UP000053661; Unassembled WGS sequence.
DR   GO; GO:1990130; C:GATOR1 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0034198; P:cellular response to amino acid starvation; IEA:UniProtKB-UniRule.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR   InterPro; IPR005365; Npr3.
DR   PANTHER; PTHR13153; CGTHBA PROTEIN -14 GENE PROTEIN; 1.
DR   PANTHER; PTHR13153:SF5; GATOR COMPLEX PROTEIN NPRL3; 1.
DR   Pfam; PF03666; NPR3; 1.
PE   3: Inferred from homology;
KW   Lysosome {ECO:0000256|RuleBase:RU368069};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053661};
KW   Signal {ECO:0000256|RuleBase:RU368069};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        306..334
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          371..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        372..405
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFV06899.1"
FT   NON_TER         505
FT                   /evidence="ECO:0000313|EMBL:KFV06899.1"
SQ   SEQUENCE   505 AA;  57200 MW;  E5F316FA5F34D462 CRC64;
     SRFSDVILAT ILATKSDMCG KKFELKIDNV RFVGHPTLLQ HALGQVSKTD PSPKREMPTM
     ILFNVVFALR ANADPSVINC LHNLSRRIAI VLQHEERRCQ YLTREAKLIL AIQDEVSAMS
     ETTEGPQSPF HHILPKCKLA RDLKETYDSL CTTGVVRLHI NNWLEVSFCL PHKIHYVATN
     FIPPEAIERS LKSIRPYHAL LLLNDEKSLL NELPLDCSPA LVRVIKTTSA VKNLQQLAQD
     ADLALLQVFQ LAAHLVYWGK AIIIYPLCEN NVYMLSPNAS VCLVTLRVQE SACTARSGAE
     ALCIVFLLYF ISWVFNISFL TLQTQLIQMV IWMLQHRLLI QLHTYVCLMV PPNEEDFRAQ
     DEDMPFTARV GGRSLSTPNA LSFGSPTSSD DMTLTSPSMD NSSAELIPGG DSPLNKRMTE
     NLLASLLEHE REAILNVPAA QNPEDLRMFA RLLHYFRGRH HLEEIMYNEN MRRSQLLMLF
     DKFRSVLVVT SHEDPVISVF QSLLK
//