ID A0A093D0J0_TAUER Unreviewed; 882 AA.
AC A0A093D0J0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=Mismatch repair endonuclease PMS2 {ECO:0000313|EMBL:KFV18589.1};
DE Flags: Fragment;
GN ORFNames=N340_12003 {ECO:0000313|EMBL:KFV18589.1};
OS Tauraco erythrolophus (Red-crested turaco).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Musophagiformes; Musophagidae; Tauraco.
OX NCBI_TaxID=121530 {ECO:0000313|EMBL:KFV18589.1, ECO:0000313|Proteomes:UP000053661};
RN [1] {ECO:0000313|EMBL:KFV18589.1, ECO:0000313|Proteomes:UP000053661}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N340 {ECO:0000313|EMBL:KFV18589.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; KL470296; KFV18589.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093D0J0; -.
DR Proteomes; UP000053661; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03484; MutL_Trans_hPMS_2_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Endonuclease {ECO:0000313|EMBL:KFV18589.1};
KW Hydrolase {ECO:0000313|EMBL:KFV18589.1};
KW Nuclease {ECO:0000313|EMBL:KFV18589.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053661};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..882
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001882878"
FT DOMAIN 234..371
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 700..844
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 395..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 432..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..488
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV18589.1"
FT NON_TER 882
FT /evidence="ECO:0000313|EMBL:KFV18589.1"
SQ SEQUENCE 882 AA; 99161 MW; 8952E4B1533A2097 CRC64;
PSPRLTAFFL SSLSSLQPAG AIKPIDRQSV HRICSGQVVL NLGTAVKELV ENSLDAGATN
IDIKLKDHGA ELIEVSDNGG GVEEENFEGL TLKHYTSKIQ DFSDLIHVET FGFRGEALSS
LCALSDVTIF TCHKSAKVGA RLVFDHNGKI TQKTPFPRQQ GTTVNIQQLF HTLPVRHKEF
QRNIKKEYAK MVQLLQAYCI VSKGVRINCT NQVGQGKKSS VVSTTGSPNL KENIGAVFGQ
KQLQSLIPFV QLPPNETVCE EYGLNATEMP QNLYSITGFI SRCDHGVGRS TTDRQFFFIN
QRPCDPAKVV KLVNEVYHLY NKHQYPFVVL NVCVDSECVD INVTPDKRQI LLQEEKLLLA
ILKTSLMEMF GSDVNKLNVN QKLLDIAGNL KTLPEETEKP RVEMLPDSET GNSSGEGKRV
MTLDRLRQSF SLHETTESNF QSPKKMKQQH RSPRQMSLDT TLSAVKTQKA ISTKDSESCH
KMDSKMSIPS RKLRKLEDNA DSGFYSTSES DAGCSTPEAG SCIRSESVIN PPEEEFCNSE
QQLRNECLKT VGCSEKSLEC DIQVLDAEHK LNQVNDRTNK NKLPQEASSS SSRVKCFKSR
SFKNESNDFK AGRCSEVKNT GNFMPSFDVL VEVKKKTVPL EFSMKVLAEK VKKVIQQQQK
STETQNYRRF KAKISPGENK VAEDELRKEI SKEMFAKMEI IGQFNLGFII AKLNSDLFII
DQHATDEKYN FEMLQQHTVL QGQKLIVPQN LNLTAVNETV LIENLEIFRK NGFDFVINEN
APVTQRVKLI SLPTSKNWTF GPQDIDELIF MLSDCPGVMC RPSRVRQMFA SRACRKSVMI
GTALNVQEMR KLVTHMGEIE HPWNCPHGRP TMRHIVSLDL IS
//
