ID A0A093FAT3_TYTAL Unreviewed; 649 AA.
AC A0A093FAT3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=Calpain-9 {ECO:0000313|EMBL:KFV51366.1};
DE Flags: Fragment;
GN ORFNames=N341_05295 {ECO:0000313|EMBL:KFV51366.1};
OS Tyto alba (Barn owl).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Strigiformes; Tytonidae; Tyto.
OX NCBI_TaxID=56313 {ECO:0000313|EMBL:KFV51366.1, ECO:0000313|Proteomes:UP000054190};
RN [1] {ECO:0000313|EMBL:KFV51366.1, ECO:0000313|Proteomes:UP000054190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N341 {ECO:0000313|EMBL:KFV51366.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
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DR EMBL; KK386491; KFV51366.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093FAT3; -.
DR MEROPS; C02.006; -.
DR Proteomes; UP000054190; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00214; Calpain_III; 1.
DR CDD; cd00044; CysPc; 1.
DR Gene3D; 2.60.120.380; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR033883; C2_III.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR10183; CALPAIN; 1.
DR PANTHER; PTHR10183:SF385; CALPAIN-9; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00239}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU00239}; Reference proteome {ECO:0000313|Proteomes:UP000054190};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807, ECO:0000256|PROSITE-
KW ProRule:PRU00239}.
FT DOMAIN 9..304
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT DOMAIN 558..593
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT ACT_SITE 64
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 221
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 245
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV51366.1"
FT NON_TER 649
FT /evidence="ECO:0000313|EMBL:KFV51366.1"
SQ SEQUENCE 649 AA; 74512 MW; 26874198EF51F76D CRC64;
QECLHRGVLF EDPDFPTCNF SLFFSEKPPI PFVWKRPGDI VKDPKFILGG ATRTDICQGD
LGDCWLLAAI ASLTLNEKTL ARVVPLDQNF GPDYAGIFHF QFWQHNEWLD VVIDDRLPTF
KDRLVFLHSA EQNEFWSALL EKAYAKLNGS YEALKGGSTI EAMEDFTGGV GEMYEVKKAP
DNFCEILEKA LKRCSLVCCS IDIRSAAESE AKTPFGLIKG HAYSVTGIDE VSYRGRQVQL
IRIRNPWGQV EWNGPWSDNS LEWHSVSPSE QRRLSQAALD DGEFWMKFED FKVHFDKVEI
CNLTPDALED STAHKWEVTI HQGSWVRGST AGGCRNYLET FWTNPQIKLH LTEKDDGQDD
CTFIAALMQK DRRKLKKLGA EMLTIGYSIY ESPGRDGHLG KDFFRYHPSK ARSKTYINLR
EVSNRFKLPP GDYILVPTTF EPHQEADFCL RIFSEKKAIT EDLDENVAID LPEPLNPTPS
PQETEEEKQF RALFEQIAGK DMEIAAEELQ YVLNDVLKKT KNIKFKNLSL ISCRNIISLM
DTSGNGKLEF SEFKVFWEKM KKWINIFLQF DFDKSGSMSS YELRSALKAA GYQLNNYLLQ
LIVLRYSDEQ FQIEFDDFLN CLIRLENASR VFQALSVKNK EFINLNIGE
//
