ID A0A093FFX8_GAVST Unreviewed; 1850 AA.
AC A0A093FFX8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
DE Flags: Fragment;
GN ORFNames=N328_04698 {ECO:0000313|EMBL:KFV56607.1};
OS Gavia stellata (Red-throated diver) (Colymbus stellatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gaviiformes; Gaviidae; Gavia.
OX NCBI_TaxID=37040 {ECO:0000313|EMBL:KFV56607.1, ECO:0000313|Proteomes:UP000054313};
RN [1] {ECO:0000313|EMBL:KFV56607.1, ECO:0000313|Proteomes:UP000054313}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N328 {ECO:0000313|EMBL:KFV56607.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC Nav1.4/SCN4A subfamily. {ECO:0000256|ARBA:ARBA00038083}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR EMBL; KK632650; KFV56607.1; -; Genomic_DNA.
DR Proteomes; UP000054313; Unassembled WGS sequence.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF223; SODIUM CHANNEL PROTEIN TYPE 4 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SMART; SM00015; IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50096; IQ; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132, ECO:0000313|EMBL:KFV56607.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Reference proteome {ECO:0000313|Proteomes:UP000054313};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 40..58
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 126..145
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 157..178
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 309..326
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 346..373
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 679..697
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 709..732
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 744..768
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 789..817
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 879..902
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1114..1132
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1153..1175
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1181..1201
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1230..1256
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1354..1377
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1435..1453
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1465..1483
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1560..1588
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1662..1687
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 74..380
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 678..907
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 916..1108
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1112..1386
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1434..1697
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 449..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 954..983
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1019..1072
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 377..408
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 546..576
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1049
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1058..1072
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV56607.1"
FT NON_TER 1850
FT /evidence="ECO:0000313|EMBL:KFV56607.1"
SQ SEQUENCE 1850 AA; 209804 MW; 2D87AD44D61E993E CRC64;
NLPLIYGDPP LELIGTPLED LDPFYKDKKT FIVLNKGKSI FRFSATPALY LLGPFHPIRR
GAIKVLIHSY PCPLMFIMIT ILTNCVFMTL SNPPAWSKNV EYTFTGIYTF ESLIKILTFL
RDPWNWLDFM VISMAYITEF VDLGNISALR TFRVLRALKT ITVIPGLKTI VGALIQSVKK
LSDVMILTVF CLSVFALVGL QLFMGNLRQK CVRWPPLNDT LLGDLGLDND TLANATLYGN
FTDGIASNFT SNFTSNSTFD FEAYINDEAN FYFLEGALDA LLCGNSSDAG KCPEGYQCMK
AGRNPNYGYT SYDTFSWAFL ALFRLMTQDF WENLFQLTLR AAGKTYMIFF VVVIFLGSFY
LINLILAVVA MAYAEQNDAT MLEEQQKEEE FQQLMEQLKK HQEEQEKMVG GKEPARADYD
QGTKEALRED RAVAAKLNAL AKHLLLAKTG NSGEGSRDPA SHPGGSGGPC RSRGTALRVW
PRCLSCPMAL LSHDTPLLSP REMEKTEGIG LRVRAKHLKE MGARIRLIPS ARAWKSCCIS
AIHGGNREDR RSSSDSLPSS VAEKERDSDL NSDQDKAKDC NGQVVPKVVL ERSATVIDVR
ARLCLCCPLR VSTPINPGLE KRVGSTISVI SNAVEELEEA HQKCPSWWYK FAHTFLVWNC
CPLWVKLKEF VKLVVMDPFV DLGITICIVL NTVFMAMEHY PMTEEFENVL TVGNLVFTGI
FTAEMVLKLI ALDPYEYFQQ GWNIFDSIIV TLSLVELGLA NVQGLSVLRS FRLLRVFKLA
KSWPTLNMLI KIIGNSVGAL GNLTLVLAII VFIFAVVGMQ LFGKSYIECV CKISLDCTLP
RWHMNDFFHS FLIVFRILCG EWIETMWDCM EVAGQTMCLI VFMMVMVIGN LVVLNLFLAL
LLSSFSADSL AASDDDGEMN NLQIAIGRIT KGIDFVKTSV LMLLRRLWKG KKVAPEEEQE
PSKRDNSVLN HVDTGQEPKS EYLDGVTGKE HFFMDDLDHM NFINNPNLTV QVPIASEESD
LYEETSTQSD TEDAKNPLSS DNASSLCSTV DYKPPPPVEE EEAEEAEDSN EPEECFTEAC
VKRFPCLYVD ITSDRGKVWW NLRKTCFRIV EHDWFETFIV FMILLSSGAL AFEDIYIEQR
RVIRTILEYA DKVFSYVFVI EMLLKWVAYG FKVYFTNAWC WLDFLIVDVS IISLTANWLG
YSELGAIKSL RTLRALRPLR ALSRFEGMRV VVNALLGAIP SIMNVLLVCL IFWLIFSIMG
VNLFAGKYYR CVNTTSGELF DISVVNNKSD CMALLHTNEV RWVNVKVNFD NVGLGYLSLL
QVATFKGWMD IMYAAVDSRE VEEQPVYEIN LYMYIYFVIF IIFGAFFTLN LFIGVIIDNF
NQQKKKISKD IFMTEEQKKY YNAMKKLGSK KPQKPIPRPS NKFQGMVFDF VTKQVFDITI
MILICLNMVT MMVETDDQSE LKTSVLYKIN LVFIVIFTGE CVLKMFALRY YYFTIGWNIF
DFVVVILSIL GESCWFLRGI VLSDIIEKYF VSPTLFRVIR LARIGRVLRL IRGAKGIRTL
LFALMMSLPA LFNIGLLLFL VMFIYSIFGM SNFAYVKKEA GIDDIFNFET FGNSIICLFQ
ITTSAGWDGL LSPILNSGPP DCDPDLENPG SSVKGDCGNP SIGIFFFCSY IIISFLIVVN
MYIAIILENF NVATEESSEP LCEDDFEMFY ETWEKFDPDA TQFIAYSTLS DFVDTLQEPL
KIPKPNKIKL ITMDLPMVAG DKIHCLDILF ALTKEVLGDS GEMDALKATM EEKFMAANPS
KVSYEPITTT LKRKHEEVCA TKIQRAFRRY LLRRSVKQAS YMYRHSKDED
//
