ID A0A093FSP4_GAVST Unreviewed; 822 AA.
AC A0A093FSP4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Glutamate receptor ionotropic, NMDA 1 {ECO:0000256|ARBA:ARBA00016504};
DE AltName: Full=N-methyl-D-aspartate receptor subunit NR1 {ECO:0000256|ARBA:ARBA00032177};
DE Flags: Fragment;
GN ORFNames=N328_05636 {ECO:0000313|EMBL:KFV57376.1};
OS Gavia stellata (Red-throated diver) (Colymbus stellatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gaviiformes; Gaviidae; Gavia.
OX NCBI_TaxID=37040 {ECO:0000313|EMBL:KFV57376.1, ECO:0000313|Proteomes:UP000054313};
RN [1] {ECO:0000313|EMBL:KFV57376.1, ECO:0000313|Proteomes:UP000054313}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N328 {ECO:0000313|EMBL:KFV57376.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. NR1/GRIN1 subfamily. {ECO:0000256|ARBA:ARBA00005374}.
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DR EMBL; KK633993; KFV57376.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093FSP4; -.
DR Proteomes; UP000054313; Unassembled WGS sequence.
DR GO; GO:0017146; C:NMDA selective glutamate receptor complex; IEA:UniProt.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0022824; F:transmitter-gated monoatomic ion channel activity; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:UniProt.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR CDD; cd06379; PBP1_iGluR_NMDA_NR1; 1.
DR CDD; cd13719; PBP2_iGluR_NMDA_Nr1; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966:SF377; GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KFV57376.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054313};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 485..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 553..579
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 735..759
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 371..717
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 377..441
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV57376.1"
FT NON_TER 822
FT /evidence="ECO:0000313|EMBL:KFV57376.1"
SQ SEQUENCE 822 AA; 92267 MW; 02345F3EC7E82E6C CRC64;
QVYAILVSHP PAPNDHLTPT PVSYTAGFYR IPVIGLTTRM SIYSDKSIHL SFLRTVPPYS
HQANVWFEMM RVFNWNHVIL IVSDDHEGRA AQKKLETLLE ERESKSKKRN YENLDQLSYD
NKRGPKAEKV LQFDPGTKNV TSLLLEAKEL EARVIILSAS EDDAATVYRS AAMLNMTGSG
YVWLVGEREI SGNALRYAPD GRHPPEAPLI NGKNESAHIS DAVAVVAQAV HDLFEKENIT
DPPRGCVGNT NIWKTGPLFK RVLMSSKYSE GVTGRVEFNE DGDRKFANYS IMNLQNRKLV
QVGIYNGSHV LTNDRKIIWP GGETEKPQGY QMSTKLKIVT IHQEPFVYVK PTQADGTCRE
EFTINGDPVK KVFCTGPNET IPGRPTVALC CYGFCIDLLI RLAGVMNFTY EVHLVADGKF
GTQERVSPPP EQGWGGRAVQ GTCHVGGALA GGGQPFKYQG LTILVKKEIP RSTLDSFMQP
FQSTLWLLVG LSVHVVAVML YLLDRFSPFG RFKVNSEEEE EDALTLSSAM WLSWFLLNSG
IGEGAPRSFS ARILGMVWAG FAMIIVASYT ANLAAFLVLD RPEERITGIN DPRLRNPSDK
FIYATVKQSS VDIYFRRQVE LSTMYRHMEK HNYESAAEAI QAVRDNKLHA FIWDSAVLEF
EASQKCDLVT TGELFFRSGF GIGMRKDSPW KQNVSLAILK SHENGFMEDL DKTWVRYQEC
DSRSNAPATL TFENMAGVFM LVAGGIVAGI FLIFIEIAYK RHKDARRKQM QLAFAAVNVW
RKNLQDRKSG RAEPDPKKKA TFRSITSTLA SSFKRRRSSK DT
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