ID A0A093FXY1_GAVST Unreviewed; 626 AA.
AC A0A093FXY1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 22-FEB-2023, entry version 35.
DE SubName: Full=Rap guanine nucleotide exchange factor 4 {ECO:0000313|EMBL:KFV59226.1};
DE Flags: Fragment;
GN ORFNames=N328_05181 {ECO:0000313|EMBL:KFV59226.1};
OS Gavia stellata (Red-throated diver) (Colymbus stellatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gaviiformes; Gaviidae; Gavia.
OX NCBI_TaxID=37040 {ECO:0000313|EMBL:KFV59226.1, ECO:0000313|Proteomes:UP000054313};
RN [1] {ECO:0000313|EMBL:KFV59226.1, ECO:0000313|Proteomes:UP000054313}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N328 {ECO:0000313|EMBL:KFV59226.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the RAPGEF2 family.
CC {ECO:0000256|ARBA:ARBA00010829}.
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DR EMBL; KK637544; KFV59226.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093FXY1; -.
DR Proteomes; UP000054313; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd04437; DEP_Epac; 1.
DR CDD; cd01765; FERM_F0_F1; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.8.1240; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF175; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR PRINTS; PR00103; CAMPKINASE.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00135};
KW Reference proteome {ECO:0000313|Proteomes:UP000054313}.
FT DOMAIN 37..112
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 177..278
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 317..466
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 500..579
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV59226.1"
FT NON_TER 626
FT /evidence="ECO:0000313|EMBL:KFV59226.1"
SQ SEQUENCE 626 AA; 71206 MW; B9DBC182F9E611BE CRC64;
TPLIEPHIPH RPTKTITQVP SEKILRAGKI LRNTILSRAP HMIRDRKYHL KTYRQCCVGT
ELVDWMMQQS PCVHSRTQAV GMWQVLLEEG VLNHVDQEHH FQDKYLFYRF LDDEREDAPL
PTEEEKKECD EELQDTMLLL SQIGPDAHMR MILRKPPGQR TVDDLEIIYE ELLHIKALSH
LSTTVKRELA GVLIFESHPK AGTVLFNQGE EGTSWYIILK GSVNVVIYGK GVVCTLHEGD
DFGKLALVND APRAASIVLR EDNCHFLRVD KEDFNRILRD VEANTVRLKE HDQDVLVLEK
IPAGNRVSNQ GNSQPQHKYI VMSGTSEKIL EHFLETMRPE ATLNEATDSV LNDFIMMHCV
FMPNSQLCPA LMAQYPFVTE KHHGTYHAQP SQGTEQEKMD YALNNKRRVI RLVLQWAALY
GDLLQEDEAA MAFLEEFYVS VSDDTRMIAA LKEQLPELEK IVKQVSEEPK APQKKHKVLL
QLFNTSDDRA QKRQPIRGSD EVLFKVYCMD QTYTTIRVPV SSSVKEVISA VADKLGSGEG
LIIVKMSSGG EKVVLKPHDV SVFTTLSVNG RLFACPRDQF DSLAPLPEQE GPSTGTVGTF
ELMSSKDLAH QMTIYDWELF NCVHEV
//
