ID   A0A093HIL0_STRCA        Unreviewed;       970 AA.
AC   A0A093HIL0;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   03-MAY-2023, entry version 25.
DE   SubName: Full=Pleckstrin homology domain-containing family M member 2 {ECO:0000313|EMBL:KFV79280.1};
DE   Flags: Fragment;
GN   ORFNames=N308_13734 {ECO:0000313|EMBL:KFV79280.1};
OS   Struthio camelus australis.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC   Struthio.
OX   NCBI_TaxID=441894 {ECO:0000313|EMBL:KFV79280.1, ECO:0000313|Proteomes:UP000053584};
RN   [1] {ECO:0000313|EMBL:KFV79280.1, ECO:0000313|Proteomes:UP000053584}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N308 {ECO:0000313|EMBL:KFV79280.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KL206141; KFV79280.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A093HIL0; -.
DR   STRING; 441894.ENSSCUP00000007480; -.
DR   Proteomes; UP000053584; Unassembled WGS sequence.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-KW.
DR   CDD; cd13309; PH_SKIP; 1.
DR   CDD; cd17680; RUN_PLEKHM2; 1.
DR   Gene3D; 1.20.58.900; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR004012; Run_dom.
DR   InterPro; IPR037213; Run_dom_sf.
DR   InterPro; IPR047327; RUN_PLEKHM2.
DR   PANTHER; PTHR46556; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 2; 1.
DR   PANTHER; PTHR46556:SF1; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 2; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF02759; RUN; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00593; RUN; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF140741; RUN domain-like; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50826; RUN; 1.
PE   4: Predicted;
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053584}.
FT   DOMAIN          16..138
FT                   /note="RUN"
FT                   /evidence="ECO:0000259|PROSITE:PS50826"
FT   DOMAIN          722..824
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          190..536
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        197..270
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        396..420
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        508..535
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFV79280.1"
FT   NON_TER         970
FT                   /evidence="ECO:0000313|EMBL:KFV79280.1"
SQ   SEQUENCE   970 AA;  106925 MW;  E599AE4FF3E1287E CRC64;
     LQSYFAACED ETPAIRNHDK VLQRLCEHLD HALLYGLQDL SSGYWVLVVH FTRREAIKQI
     EVLQHVSTNL GRSRAWLYLA LNENSLESYL RLFQENLSLL HKYYVKNALV CSHDHLTLFL
     TLVSGLEFIR FELDLDAPYL DLAPYMPDYY KPQYLLDFED RLPSSVHGSD SLSLNSFNSV
     TSTNLEWDDS AIAPSSEDGD LTDTLSCPRS TASEANGSKA SVKSPTQRYN PFNEEKADVP
     SSTETTPVHT ASQEKAEATP EGTDQSESCT ELEVIRLARR KKAGKKKKAK PEEPVNTTAP
     IAPEASIQQA GGDSGVNGLS DRDDLPGDDG LAPPGDEPSL AGPEESSERS ALGQLALRIP
     EMKDTSMESV GQPLSKVMDR LNGQLDPGSW NAPLEPPGQS FRTGTPGETP DGSSSGDLNE
     GISAPMDFYR FTIESPNAPA SGGGHHDTPG PGQPPHVSGS PEAPEQEESR EGKAVGAVEE
     SGGAANEPQV GQTETTNPEA LCELKKEQPS PSPSSAEDSG VEEGQGSPSE LTHPSEFRVD
     NNHLLLLMIH VFRENEEQLF RMIRMSTGHM EGNLQLIYVL LTDCYVYLIR KGAAEKPYMV
     EEAVSYNELD YISVGLDQQT VTLVCTNRRK QFLLDTADVA LTEFFLVSLK SAMIKGCREP
     PYPSILTDAT MEKLALAKFV AQESKCEACD VVVRFYGLVH WEDPMDEALG PTPNSYASAE
     NAVTKDGILH YKAGTSYLGK EQWKTCFVVL SNGILYQYPD RTDVTPLLSI NMGGEQCGGC
     RRSNTTDRPH SFQVILTDRP SLELSADNEA DMADWMQYFC QAVSKGVIPQ GVAPTPCVPC
     CLVLTDKKAF TCHEDCQTSF FRSLGTMELT DVTAVSTEAG KEYCILEFAQ DRKQFLPPWV
     LYFSCTTELE RFLSALNAAW RNIYQVDLLH KAILDAAVKK KCEDAQSLID SAWQRSDSLC
     RGRAERDPWC
//