ID A0A093HIS1_STRCA Unreviewed; 692 AA.
AC A0A093HIS1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=N308_11022 {ECO:0000313|EMBL:KFV82558.1};
OS Struthio camelus australis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC Struthio.
OX NCBI_TaxID=441894 {ECO:0000313|EMBL:KFV82558.1, ECO:0000313|Proteomes:UP000053584};
RN [1] {ECO:0000313|EMBL:KFV82558.1, ECO:0000313|Proteomes:UP000053584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N308 {ECO:0000313|EMBL:KFV82558.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
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DR EMBL; KL206459; KFV82558.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093HIS1; -.
DR STRING; 441894.ENSSCUP00000018851; -.
DR Proteomes; UP000053584; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.700.40; -; 1.
DR Gene3D; 3.40.50.20; -; 1.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR18866; CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE; 1.
DR PANTHER; PTHR18866:SF33; METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000053584}.
FT DOMAIN 18..464
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 137..334
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 610..685
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV82558.1"
FT NON_TER 692
FT /evidence="ECO:0000313|EMBL:KFV82558.1"
SQ SEQUENCE 692 AA; 76489 MW; 1FBBAD790D319606 CRC64;
WNLGQRFVKC ASTIGSHSIE KILIANRGEI ACRVMRTARK MGVKSVAVYS EADRNSMHVA
MADEAYCIGP APSQQSYLAM EKIMQVAKVS AAQAVHPGYG FLSENTEFAE LCKQEGIIFI
GPPSSAIRDM GIKSTSKAIM SAAGVPVVEG YHGEDQSDEC LKEHAKRVGY PVMIKAVRGG
GGKGMRIAHS EKEFLDQLES ARREAKKSFN DDAMLIEKFV DDPRHVEVQI FGDQHGNAVY
LFERDCSVQR RHQKIIEEAP GPGINPDVRK KLGEAAVKAA KAVNYVGAGT VEFIMDSQHN
FYFMEMNTRL QVEHPVTEMI TGTDLVEWQL RVAAGEKIPL MQEEIRLRGH AFEARIYAED
PNNNFMPGAG PLLHLSTPPP DSFTRIETGV RQGDEVSVHY DPMIAKLVVW AEDRQAALRK
LRYSLHQYHI VGLNTNIDFL LSLSGHPQFE AGNVHTNFIP QHHDELFPTK TATPHEVVCQ
AALGLLLKEK MVTDAFRDQS ADKFSPFASS SGRRINMLYT RKLSLLDGEN IVDVTVNYNQ
EGSYNMQIKD KMFLISGDIF NEGDSVYLRS SVNGTVCKSK LVILDNTIYL FSPEGSAQIG
LPVPKYLSAV SSVGMQGGAV APMTGTIEKV FVKAGDKVQI GDPLMVMIAM KMEHTIRAPK
AGVIKKVNFQ EGAQANRHAP LIEFVDEESE SK
//
