ID A0A093HJ91_TYTAL Unreviewed; 1436 AA.
AC A0A093HJ91;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=DNA mismatch repair protein Mlh3 {ECO:0000313|EMBL:KFV54633.1};
DE Flags: Fragment;
GN ORFNames=N341_02866 {ECO:0000313|EMBL:KFV54633.1};
OS Tyto alba (Barn owl).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Strigiformes; Tytonidae; Tyto.
OX NCBI_TaxID=56313 {ECO:0000313|EMBL:KFV54633.1, ECO:0000313|Proteomes:UP000054190};
RN [1] {ECO:0000313|EMBL:KFV54633.1, ECO:0000313|Proteomes:UP000054190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N341 {ECO:0000313|EMBL:KFV54633.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; KK390848; KFV54633.1; -; Genomic_DNA.
DR Proteomes; UP000054190; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03486; MutL_Trans_MLH3; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF47; DNA MISMATCH REPAIR PROTEIN MLH3; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054190}.
FT DOMAIN 211..350
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 1193..1374
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 418..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 734..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1436
FT /evidence="ECO:0000313|EMBL:KFV54633.1"
SQ SEQUENCE 1436 AA; 160214 MW; A8E51E4BCBBDAEEA CRC64;
MIKCLVEDVR ARLRSGVTIS SLGQCVEELV LNSIDAKATC VAIRVDLEAF KIQVVDNGSG
MGREDLNAMG KRYFTSKCSS VGDLENLMFY GFRGEAVASI ANLASVVEIS SKTSRTAKTF
VKLFHNGQPL EVCEGELSRP SGGTTVTVCN LFHQLPVRRR CMDPVLEFER VRQKVEAVSL
MHPSVSFSLR NDVSCSMVLQ LPKTRDVYSR FCQIYGLGRS QKLREINHKS GGFEISGYIS
TEGHYNKNMQ FLYVNRRLVL KTRLHKLIDF LLRKESVICK AKSGPASRQA SSSPGHHRCG
PELYGIFILN VTCAYSDYDV CLEPSKTLIE FQNWDVLLTC IEEGVKIFLK REHLFIEPCS
EDIREFNEDN DFCLYNAPVL KPSLSDKKNI QDSFKKAYDE IVDSYEMCNL QSKDVKRKSV
SGKNSSSLIE SNKNLQETEI APNQKTAELS DPCRNNKAEI PLPSKDDTAS DFVISNISEQ
EPKDTNSSQK ASDTHLKPSE DLCSSFSGGA RSEIQKINSC GDLQHCAENY IKGVGSQQGK
IVQKSNMVHI LNNDVIQSRS EREDPTETAM GPETVSGSSL MRLCNTRRGD RETAGVIDDA
GRGSVSSIPL KLCSAGLTTR VVQSEPSHES EQTETNLTLN AQCRPGPASA KDIFGHKVNF
PIQSLNAKDM CSNTNKEYTP PYAREVCMID GNKRSENKTL SNQVSEGIAM SIATGKRHYE
TSNVTELPVA TSGIPHSKVT KSTRRQIAVP RSQPSKKLSL STQLGSLEKF RRFYGRVKCI
LPTPLSEQSV LNSQANCDFS KNENDTHGNL STCETPTVED TDSNNSSHVF VSLKETLFCS
GETSQDKRAL CQSPLTLSDY SEVSKKNTTC RRSPGSLSCK LFRMRSDHKE VEQLGEHLQT
DSSRKDDYSF DFESSNNDFS YNAYQTCKSL VEEMRECNYS ISKGDACWQA NNMRAESIKS
TVSPSPLSSI EGEYTVSSSS VFSLPAQKDC ADICKDKSTL DESSEQNLKN TEVPHMTFLS
NLEFSADNAS TGNPRNDLRC SDWLQDFDVS SGKTVYINKA TGLSTYNTPP TEGFQAACIQ
DITTMAVNVV TESGIQFRCH PFRSEILLPF LPRPRNKKTL ASQDPRGDTY LQDEIPRESL
QSLLSEWDNP VFVPCPEIAV DVTSTQADNL AVKIHNILYP YRFTKDMVHS MQVLQQVDNK
FIACLINTRN EMDKKADGNL LILVDQHAAH ERIRLEQLIA DSYEKKAAAC GKKKLLSSSI
SPPLEIEVTE EQSRFLRCCY KNLEDLGLEL SFPETNSSLI LVRKVPQCFI EREANELRRK
RQPVTKSIVE ELIQEQVELV QTTGGGARGT LPLTLLKVLA SQACHGAIKF NEHLTLEESC
RLIEALSSCQ LPFQCAHGRP SMMPLADIDH LQQEKQPKPN MGRLRKMSRA WHLFGK
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