ID A0A093HL31_STRCA Unreviewed; 495 AA.
AC A0A093HL31;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Microcephalin {ECO:0000256|ARBA:ARBA00017027};
DE Flags: Fragment;
GN ORFNames=N308_15000 {ECO:0000313|EMBL:KFV82416.1};
OS Struthio camelus australis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC Struthio.
OX NCBI_TaxID=441894 {ECO:0000313|EMBL:KFV82416.1, ECO:0000313|Proteomes:UP000053584};
RN [1] {ECO:0000313|EMBL:KFV82416.1, ECO:0000313|Proteomes:UP000053584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N308 {ECO:0000313|EMBL:KFV82416.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Implicated in chromosome condensation and DNA damage induced
CC cellular responses. May play a role in neurogenesis and regulation of
CC the size of the cerebral cortex. {ECO:0000256|ARBA:ARBA00025455}.
CC -!- SUBUNIT: Interacts with CDC27 and maybe other components of the APC/C
CC complex. Interacts with histone variant H2AX under DNA damage
CC conditions. {ECO:0000256|ARBA:ARBA00026061}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
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DR EMBL; KL206453; KFV82416.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093HL31; -.
DR Proteomes; UP000053584; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0021987; P:cerebral cortex development; IEA:InterPro.
DR CDD; cd17716; BRCT_microcephalin_rpt1; 1.
DR CDD; cd17736; BRCT_microcephalin_rpt2; 1.
DR CDD; cd17751; BRCT_microcephalin_rpt3; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 3.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR022047; Microcephalin-like.
DR InterPro; IPR029504; Microcephalin_mammal.
DR PANTHER; PTHR14625; MICROCEPHALIN; 1.
DR PANTHER; PTHR14625:SF3; MICROCEPHALIN; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF12258; Microcephalin; 1.
DR Pfam; PF12738; PTCB-BRCT; 1.
DR SMART; SM00292; BRCT; 2.
DR SUPFAM; SSF52113; BRCT domain; 2.
DR PROSITE; PS50172; BRCT; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000053584}.
FT DOMAIN 1..85
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 316..408
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT COILED 158..185
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV82416.1"
FT NON_TER 495
FT /evidence="ECO:0000313|EMBL:KFV82416.1"
SQ SEQUENCE 495 AA; 55965 MW; D4E1F3E0C58AA2D3 CRC64;
ISAFVEVWSS NRTENYSKTF EQQLLDMGAK VSKTFNKQVT HVVFKEGRLA TWRKAQKTGV
KIVSVLWVEK CRETGVRVDE SLFPAVYTNE GLPLLIKKHK CMQPKDFVEK TPENDRKLQR
RLDQMAKELA IQKTASNAEA DIPVLLFEDD GSLVYSPVNK IKDQCSAMER RIKEMKEKRE
NLSLTASQIS QILPCNSPKD CPPSTCVLTD SADALPEKQM EDCLNSSFDD LWGTDKFKRR
KTEVAEHISD AQSDVCVSKS ASVNSPSCSY DQKTLTPKQS NRRCLGDENE VSECHVTDGS
CKLFNEQENK LNGGLRKNRR LQKPTRTLVM TSMSSEKQNT IIQVVNKLGD FLFSDDVCET
TSHVVAGSPR RTLNVMLGIA RGCWIVSYEW VLWSLELGHW TSEEPYELSS NFPAAPICRL
QRHLSTGKYQ QNLFSSQPAM FVSPTSQPPC KKLIELIQLS GGKICKALRQ AKICIGGYPA
KKNQEIKYLS EKWIL
//
