ID A0A093HQW9_STRCA Unreviewed; 356 AA.
AC A0A093HQW9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 22-FEB-2023, entry version 23.
DE RecName: Full=SPRY domain-containing SOCS box protein 3 {ECO:0000256|ARBA:ARBA00014684};
DE Flags: Fragment;
GN ORFNames=N308_13067 {ECO:0000313|EMBL:KFV84056.1};
OS Struthio camelus australis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC Struthio.
OX NCBI_TaxID=441894 {ECO:0000313|EMBL:KFV84056.1, ECO:0000313|Proteomes:UP000053584};
RN [1] {ECO:0000313|EMBL:KFV84056.1, ECO:0000313|Proteomes:UP000053584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N308 {ECO:0000313|EMBL:KFV84056.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be a substrate recognition component of a SCF-like ECS
CC (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase
CC complex which mediates the ubiquitination and subsequent proteasomal
CC degradation of target proteins. {ECO:0000256|ARBA:ARBA00004094}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the SPSB family.
CC {ECO:0000256|ARBA:ARBA00010910}.
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DR EMBL; KL206595; KFV84056.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093HQW9; -.
DR STRING; 441894.ENSSCUP00000015861; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000053584; Unassembled WGS sequence.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd12876; SPRY_SOCS3; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035754; SPRY_SPSB3.
DR PANTHER; PTHR12245; SPRY DOMAIN CONTAINING SOCS BOX PROTEIN; 1.
DR PANTHER; PTHR12245:SF5; SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 3; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000053584}.
FT DOMAIN 86..276
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 278..311
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 32..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV84056.1"
FT NON_TER 356
FT /evidence="ECO:0000313|EMBL:KFV84056.1"
SQ SEQUENCE 356 AA; 39598 MW; 2C6586C5BE2BF985 CRC64;
TMARRTRNSR AWHFVLSGVR RDADTRAVAL ATGSRGRGYD SDGQHSDSDS EPEFSSLSPS
IPSAIPVTGE SYCNCENQNE APYCSSLHAI HRVKDCQCGE EDEYFDWVWD DLNKSTATLL
TCDNRKVNFH MEYSCGTAAI RGNKELADGQ HFWEIKMTSP VYGTDMMVGI GTSDVNLDKY
RHTFCSLLGK DEDSWGLSYT GLLHHKGDKT NFSSRFGQGS IIGVHLDTWH GTLTFFKNRK
CIGVAATKLQ NKKFYPMVCS TAAKSSMKVI RSCASCTSLQ YLCCYRLRQL LPNYVDTLEV
LPLPPGLKQV LHNKLGWVLS MNYSTSKPSS SSSGSDSDSS CGSDAEACQR KRCRRT
//
