ID A0A093HXG4_STRCA Unreviewed; 4151 AA.
AC A0A093HXG4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Cytoplasmic dynein 2 heavy chain 1 {ECO:0000256|ARBA:ARBA00023902};
DE Flags: Fragment;
GN ORFNames=N308_05230 {ECO:0000313|EMBL:KFV87413.1};
OS Struthio camelus australis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC Struthio.
OX NCBI_TaxID=441894 {ECO:0000313|EMBL:KFV87413.1, ECO:0000313|Proteomes:UP000053584};
RN [1] {ECO:0000313|EMBL:KFV87413.1, ECO:0000313|Proteomes:UP000053584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N308 {ECO:0000313|EMBL:KFV87413.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; KL206940; KFV87413.1; -; Genomic_DNA.
DR STRING; 441894.ENSSCUP00000022247; -.
DR Proteomes; UP000053584; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR049400; DYNC2H1_AAA_dom.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF22; CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF21264; DYNC2H1_AAA_dom; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053584}.
FT DOMAIN 1683..1829
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1970..2126
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2282..2430
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 1076..1110
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2939..2976
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3102..3192
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 4151
FT /evidence="ECO:0000313|EMBL:KFV87413.1"
SQ SEQUENCE 4151 AA; 475364 MW; 6ED30C6A62CA517C CRC64;
MAGERDKRKR FISATAANYF GLDPAALSPG LCASPELANF LDDGNEFLLV VQHSGTQLTA
SNKIDSTDSE NNVLVFFKLR PDVITEDNLH SNILVSSMLD SPINTLYQAV RQVFAPVLLR
DERWSKAFDP KLQKLLSELE AGLSTVLRRS DPNYMGTKFS EDDVRAILTP TDEFHFWIER
AHHGSKLYSK ERASHFKGLF EGIEKDYYNL DSLSLFEVVD LVETTRDTVD GVWRQTEHDP
YPQLRMHNLL DVIGGCLGRF VQRKLAALNL WEDAFHIVKE NLKAGILICE QWVSACEYLT
GQLWQRYTLH PWKNEKYFPE SLAKLGKRLD EVLTVRTLHE KLIFFLSAGE QNALHLAQVF
EPFAGLNPVH YNPYTEPLWK AAVSQYERII APAEQKIASK LKKFISEIQD SPQQLLQTFQ
KYKELVKRPN VSKDLLFERE TLLARLQDSV KAYQIDFETR CHGVPGDVSG PLSGKNLSEV
VNNIVWVRQL ELKVDDAIQL AEAILFDLSG FQTFHRSADS LLEQFKVYEQ EQFDDWSRNI
QSELSNPKSG LCIQANSPVM ELDHVSGTLN ILYSDHLVIL LREVRQLSAL GFSIPSKIQH
VANTAQKFCK QAVILKQVAH FYNSIDQQMI ASQKPMMLQS ALAFEQIIKH SKSGPGGKAQ
ITWDNPRELE AYILKLQAAA ERLSTENRKL RKWHKNFIEK VISLMNIDLL RQQQRWKEGV
QELRTGFANL ESQARGFNSC EMKAWRQHWN HQLYKALEHQ YQMGLEALNE NLPEINIDLV
FKQGRLQFRP PFEEVRARYY REMKRFISIP NQFRGVSETE EESIFTVMTE RNAHGFLTAF
SKAEDLFRRL AEVSNQFKEW IVIGQVDMEA LVKKHLSSKQ DWERNFKALK VRGKEAERLP
STIKIDCLIV NCNPVKTVID DFIQTLYDVL VFSLRKSIQA HLHEISSFLT DAMETLVVRP
QTIEEIAEDN LKYAHLLEGK EGIFPLFQEA EDRNKLLRTV AGTGLDTIGN LRATWDKFEL
MMESHQLMIT EQIEIMKGNV MSRVNIYLQD LEKFKARWDQ LKPSDDVIET GDQDVLEKSA
QIIKEKKKEF DELETTKEKL IEECHHFKLE EPDFSLSTVV CQDIKSCSEV WALYEEFYQG
FQEKAKEDWI TFRSKIYLFE EFLFNWHDKM RKIEEHTIMT VKLQKEVDKY KMIIPLLKYV
RGEHLSPDHW LDLFRLLGFP RGTTLEGLLF GDLLKVTDAI IEKATELKDL NCRAQGEVTI
REALRELELW GAGAVFTLTD YEDSQSKTIR LIKDWKDIVN QVGDHRCLLQ SLKDSPYYKG
FEDKVSIWEK KLAELDEYLQ SLNQIQRKWV YLEPIFGRGA LPKEQARFNR VDEDFRSIMS
DIKKDNRITS LNARTGLRNT LITILDQLQR CQRSLNEFLE EKRSAFPRFY FIGDDDLLEI
LGQSMNPLVI QSHLKKLFAG INSVSFDEDF KYIIAMKSVE GETVLLNNKI RLSNDVEVWL
SSLALEMKET LKKLLLDCVT TGKKSQGSID PSLFPAQILS LAEQIQFTED VENAIKERNL
QQLELELMAK LEHYTSIDTS IEDTGSTESG ILELKLKALI LDIIHNIDVV KQLNQAQVHN
VEDWAWKKQL RFYMKDEKCY VQMVDAELQY TYEYQGNSPK LVYTPLTDKC YLTLTQAMRM
GLGGNPYGPA GTGKTESVKA LGGLLGRQVL VFNCDEGIDV KSMGRIFVGL VKCGAWGCFD
EFNRLEEAVL SAVSMQIQTI QHALKKHSPV CELLGKKVEM NHNSGIFITM NPAGKGYGGR
QKLPDNLKQL FRPVAMTHPD NELIAEVILY SEGFKDAKTL GRKLVAIFNL ARELLTPQQH
YDWGLRALKT ALRGCGSLLR QLKKCETKEE INESRMVVQA LRLNTMSKLT FADCARFDAL
VKDVFPGIDF KDVEYAELTA ALQQAFEEAN LEIIRTQVKK ALELYEQLHQ RMGVVIVGPS
GAGKSTLWRM LKTALGKTGQ VVKQYTMNPK AMPRHQLLGH IDMDTREWSD GMLTNSARQV
VREPRDITSW IICDGDIDPE WIESLNSVLD DNRLLTMPSG ERIQFGSNVN FIFETHDLSC
ASPATISRMG MIFLSDEDTD LNSLIKSWLR SQPEECRYNL ENWIGDYFEK ALNWVVKQND
YVVETSVVGT VMNGLSHLHG CTDRGQFIIN LLRGLGGNLN MKSRQEFTKQ IFSWARESPP
DPRKPLDTYY DTGTGELMTY QLKKPENLTA DDFSNLQTLP VIQTPDMQRG LDYFRPWLDF
HNKQPFLLVG PEGCGKGMLL RYAFSQLRST QIATVHCSAQ TTSQHLLQKL SQTCIIISTN
TGRVYRPKDC ERLVLYLKDI NLPKPDKWGT STLVAFLQQV LTYEGFYDEN LEWVGLENIQ
IVASMSAGGT LGRHKLTTRF TSIVRICAID YPERDQLQTI YSAYLEPVLQ KNLKNHPAWG
SLAKIHQLAG SMVQVYEQVR VKFTVDDHSH YLFTPCILTQ WVLGLFRYDL AGGSSTQTVD
YVLEIVAYEA HRLFRDKIVG IKELSVFDNV LMKVFQGDWG SDVLDNMADI FYVTWGTYHE
AFIGPGQALP PHGRPLGRLN STDLKDIIKK GITHYGRDKK EIEILLFQEV INYISRVDRV
LSFPGGSLLL AGRSGVGRRT VTSLVSHMHG AVLITPKISR GYELKQFKND LKHVMELAGI
EAQQVVLLLE DYQFVHSTFL EMINSLLSSG EVPGLYKIEE LEPLLSPLKD QASQDGFTGP
IFNYFTYRIQ QNLHVVLIMD STNLNFTINC ESNPALYKKC QVLWMESWSE NSMKKIPEML
LNDSDEQEKT GKAHKELKKK HSGDSDFLKS FLTIHESCKT YGATPSRYMT FLRTYSTINS
SKRRELIKRQ NHLQAGVSKL NEAKALVDEL NRKAGEQSVL LKTKQDEADA ALQEITVSMQ
VASEQKTEME KIKQRIAEEA AEIEERKRKI EDELKEVQPL VNEAKLAVGN IKPESLSEIR
SLRMPPDIIR DILEGVLRLM GIFDTSWVSM KSFLAKRGVR EDIATFDARH IPKEIRESVE
ELLSKNRTSF DPKNAKRASA AAAPLASWVN ANVQYSHVLE RIQPLEKEKA GLEANLKKTE
DRKQNLEDLL NSVGQKVSEL KDKFQCRTTE AAKLEAELSK AQKTLKAAEV LISQLDREHK
RWSTQVSEIT DELATLPKRA QLAAAFITYL SAAPEDQRKA SLDEWTKSAD LEKFDVRRFL
CTESEELVWK SEGLPSDDLS IENALVILQV NFTVCPFLID PSFRATEWLK THLKESRLEV
INQQDTNFLT TLELAVRFGK TLIIQEVDRV EPVFYPLLRK DLVAEGPRYA VQIGDKMIDY
NEEFRLFLST RNPNPFIPPD ASSIVTEVNF TTTGSGLRGQ LLAITLQHEK PDLEEQKTKL
LQQEEDKKIQ LAKLEESLLE TLATSQGNIL ENKDLIESLN QTKASSALIQ ESLAESHRLQ
SFLDQERDAY LPLAESASKM YFIISDLSKI NNMYRFSLAA FLRLFQRALQ SEQNSVNTEE
RIKSLIGSLK YMVYEYVCRC LFKADQLMFA LHFVRGMHPE LFQENEWDTF TGVIIGDTVR
KPDSQRGVRD QLPSWIEQER AWAIASLKIS LPGLYRTLCF EDVDLWRTFS QSSVCEQDFP
SSIVNRISLF QQVLVVQAVR PDRLQSAMAL FACKALGIKE LSPSPLNLKR LYKETLEIEP
ILIIISPGAD PSQELQELAS IEKNTECYHQ IAMGQGQAEL AIQTLKECAR NGEWLCLKNL
HLVISWLPVL EKELNTLQPQ PNFRLWLTAE VHPKFTPILL QSSLKITYEA PPGLKKNLLR
TYESWMPEQI NKKGNLSRAH SLFCLAWFHA VCQERRNYIP QGWTKFYEFS LSDLRAGFDI
IDRLFEGSKD FQWEFVHGLF ENAIYGGRID NYFDMRVLRS YLEQLFNSRI IGSLNGRGKK
MTRFPYSISL PNSCSILDYR NIIESLPEDD KPEFFGLPAN IARSSQRMIS SQVISQLRIL
SRSVTAGCKF DREVWSTELS PVLNLWKKLN QNSNLIHQKV SPPMERQGSP ILSFITLEQF
NAILLVQSVH QSLASLSKVI RGTSLLSSEV QRLASALLNQ KCPLTWQSKW EGPEDPLQYL
RGLVARALAI Q
//
