ID   A0A093ICS0_FULGA        Unreviewed;       338 AA.
AC   A0A093ICS0;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating {ECO:0000313|EMBL:KFV96323.1};
DE   Flags: Fragment;
GN   ORFNames=N327_03177 {ECO:0000313|EMBL:KFV96323.1};
OS   Fulmarus glacialis (Northern fulmar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Procellariiformes; Procellariidae;
OC   Fulmarus.
OX   NCBI_TaxID=30455 {ECO:0000313|EMBL:KFV96323.1, ECO:0000313|Proteomes:UP000053806};
RN   [1] {ECO:0000313|EMBL:KFV96323.1, ECO:0000313|Proteomes:UP000053806}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N327 {ECO:0000313|EMBL:KFV96323.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219, ECO:0000256|RuleBase:RU004475}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KK584652; KFV96323.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A093ICS0; -.
DR   Proteomes; UP000053806; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|RuleBase:RU004475};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU004475};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053806};
KW   Transmembrane {ECO:0000256|RuleBase:RU004475};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU004475}.
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004475"
FT   DOMAIN          5..256
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFV96323.1"
FT   NON_TER         338
FT                   /evidence="ECO:0000313|EMBL:KFV96323.1"
SQ   SEQUENCE   338 AA;  37763 MW;  620D84197EF22138 CRC64;
     GKKCIVIGGS GFLGQHMVEQ LLEKGYTVNV FDIQKRFDND RVQFFLGDLC DKEALLPALQ
     GVSVAFHCAS PAPSSDNREL FYKVNFMGTK AVIEACKEAG VQKLVLTSSA SVVFEGTDIK
     NGSEDLPYAK KPIDYYTETK ILQEKEVLSA NDPGNNFFTT AIRPHGIFGP RDPQLVPILI
     QAAKSGKMKF IIGDGKNLVD FTYVENVVHG HILAAENLQK DSPLCGKAFH ITNDEPVPFW
     AFMSRILTGL NYDPPKYHIP YWLAYYLALF LSLVLWLLSP LVTIKPTFTP MRVALAGTFH
     YYSCERAKRD MGYKPVVSLD EAIDRTLQSY PHLLRAKA
//