ID A0A093IRP3_EURHL Unreviewed; 1169 AA.
AC A0A093IRP3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
DE Flags: Fragment;
GN ORFNames=N326_00706 {ECO:0000313|EMBL:KFW05390.1};
OS Eurypyga helias (Sunbittern) (Ardea helias).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Eurypygimorphae; Eurypygiformes;
OC Eurypygidae; Eurypyga.
OX NCBI_TaxID=54383 {ECO:0000313|EMBL:KFW05390.1, ECO:0000313|Proteomes:UP000054232};
RN [1] {ECO:0000313|EMBL:KFW05390.1, ECO:0000313|Proteomes:UP000054232}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N326 {ECO:0000313|EMBL:KFW05390.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC channel in the central nervous system and plays an important role in
CC excitatory synaptic transmission. L-glutamate acts as an excitatory
CC neurotransmitter at many synapses in the central nervous system.
CC {ECO:0000256|RuleBase:RU367118}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104,
CC ECO:0000256|RuleBase:RU367118}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034104}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. NR2B/GRIN2B subfamily. {ECO:0000256|ARBA:ARBA00038189}.
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DR EMBL; KK567738; KFW05390.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093IRP3; -.
DR Proteomes; UP000054232; Unassembled WGS sequence.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004970; F:glutamate-gated receptor activity; IEA:UniProt.
DR GO; GO:0022890; F:inorganic cation transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd13718; PBP2_iGluR_NMDA_Nr2; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 3.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR018884; NMDAR2_C.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966:SF382; GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF10565; NMDAR2_C; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367118};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU367118};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU367118};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|RuleBase:RU367118};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW Reference proteome {ECO:0000313|Proteomes:UP000054232};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367118};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367118};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118}.
FT TRANSMEM 224..246
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 267..284
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 296..321
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 487..510
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT DOMAIN 104..465
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 106..169
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 835..873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 940..984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 950..973
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW05390.1"
FT NON_TER 1169
FT /evidence="ECO:0000313|EMBL:KFW05390.1"
SQ SEQUENCE 1169 AA; 131245 MW; 9772825F0D9AD106 CRC64;
RYLINVTFEG RNLSFSEDGY QMHPKLVIIL LTKERKWERV GKWKEKKLQM KYYVWPRFEL
YPDSEEREDD HLSIVTLEEA PFVIVENVDP LSGTCMRNTV PCQKRIVTEN KTDEEPDYMK
KCCKGFCIDI LKKISKSVKF TYDLYLVTNG KHGKKINGTW NGMIGEVVTK RAYMAVGSLT
INEERSEVVD FSVPFIETGI SVMVSRSNGT VSPSAFLEPF SADVWVMMFV MLLIISAVAV
FVFEYFSPVG YNRCLADGRE PGGPSFTIGK AIWLLWGLVF NNSVPVQNPK GTTSKIMVSV
WAFFAVIFLA SYTANLAAFM IQEEYVDQVS GLSDKKFQKP NDFSPPFRFG TVPNGSTERN
IRNNYPEMHS YMVKFNQRGV DDALFSLKTG KLDAFIYDAA VLNYMAGRDE GCKLVTIGSG
KVFASTGYGI AIQKDSGWKR QVDLAILQLF GDGEMEELEA LWLTGICHNE KNEVMSSQLD
IDNMAGVFYM LGAAMALSLI TFICEHLFYW QFRHCFMGVC SGKPGVVFSI SRGIYSCIHG
VAIEERQSAM NSPTATMNNT HSNILRLLRT AKNMANLSGV NGSPQSALDF IRRESSVYDI
SEHRRSFTHS DCKSYNNPPC EENLFSDYIS EVERTFGNLQ LKDSNVYQDH YHHHHRPHSI
GSTSSIDGLY DCDNPPFNAQ SRSIGKKPLD LGLPPAKHSQ LGDLYGKFSF KSDRYGGSGA
HDDLIRSDVS DISTHTVTYG NIEGNAAKRR KQQYKDSLKK RPASAKSRRE FDEIELAYRR
RPPRSHDHQR YRYFRDKEGL RDFYLDQFRA KENSPHWEHV DLTDIYKERG DEFKRDTGGG
GGGSCTNRAH HKHGSGEFGG GNEHKHGVVS GVPAPWEKNL TNLDWEDRSG ANFCRGCPSK
LHNYTPSVVG QNSTRQACIR CEACKKAGNL YDISEDNSLQ ELDQPPAPVP VATSATSSSK
YPQSPSNSAS KVQKKNRNKL RRQHSYDTFV DLQKDDSALA PRSVSLKDKG RFLEGSPYAH
MFEMPASETT FANNKSSVPA TSYHHHNNPG SSGGYMLSKS LYPDRVTQNP FIPTFGDDQC
LLHGSKSYFF RQPVVAGGPK ARPDFRAIIT TNKPVVSALH GAVPARFQKD ICIGNQSNPC
VPNNKNPRAF NGSSNGHVYE KLSSIESDV
//
