ID A0A093JST0_STRCA Unreviewed; 1216 AA.
AC A0A093JST0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
DE Flags: Fragment;
GN ORFNames=N308_01651 {ECO:0000313|EMBL:KFV81659.1};
OS Struthio camelus australis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC Struthio.
OX NCBI_TaxID=441894 {ECO:0000313|EMBL:KFV81659.1, ECO:0000313|Proteomes:UP000053584};
RN [1] {ECO:0000313|EMBL:KFV81659.1, ECO:0000313|Proteomes:UP000053584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N308 {ECO:0000313|EMBL:KFV81659.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; KL206356; KFV81659.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093JST0; -.
DR STRING; 441894.ENSSCUP00000012877; -.
DR Proteomes; UP000053584; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005112; F:Notch binding; IEA:InterPro.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 13.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 15.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR026219; Jagged/Serrate.
DR InterPro; IPR011651; Notch_ligand_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR PANTHER; PTHR24044:SF421; PROTEIN JAGGED-2; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 10.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF07657; MNNL; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR02059; JAGGEDFAMILY.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 16.
DR SMART; SM00179; EGF_CA; 14.
DR SMART; SM00215; VWC_out; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 7.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 10.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 15.
DR PROSITE; PS01186; EGF_2; 9.
DR PROSITE; PS50026; EGF_3; 14.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000053584};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1061..1084
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 170..214
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 281..319
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 321..357
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 359..395
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 397..433
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 435..470
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 472..508
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 510..546
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 575..612
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 614..650
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 652..688
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 690..726
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 729..765
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 767..803
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 805..841
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1092..1116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1149..1216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1199..1216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 172..181
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 185..197
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 205..214
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 309..318
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 347..356
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 385..394
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 423..432
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 439..449
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 460..469
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 498..507
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 536..545
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 602..611
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 640..649
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 678..687
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 716..725
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 755..764
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 793..802
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 831..840
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV81659.1"
FT NON_TER 1216
FT /evidence="ECO:0000313|EMBL:KFV81659.1"
SQ SEQUENCE 1216 AA; 134604 MW; AF1A208CD249EBB8 CRC64;
VSQSTGYFEL QLNSVRNVNG ELFNGECCDG MKSPQNLDCT RDECDTYVKV CLKEYQAKIT
PAKITPVGPC NYGFGSTPVL GGNIFYLNSN KYSHQGKNPE TGRIVIPFQF AWPRSFTLII
EAWDWDNDTK TGEDLLIERV AYAGMINPED RWKTLQFNGP VAHFEVQIRV KCDENYYSAL
CNKFCGPRDD FVGHYTCDQN GNKACMEGWM GEECKQAVCK QGCNLLHGGC STPGECKCHY
GWQGQFCDEC VRYPGCAHGS CNEPWQCNCE TNWGGLLCNK DLNYCGNHHP CLNGGTCMNT
EPDEYRCACP DGYSGKNCEI AEHACVSNPC ANGGICHEIS LGFKCLCPPG WSGPTCAIDI
DECASNPCAR GGTCIDGINS FECICPQQWI GATCQLDANE CEGKPCVNAY SCKNLIGGYY
CDCIPGWTGV NCHININDCH GQCQHGGTCK DEVNGYHCLC PRGFTGKNCE KETNECESNP
CQNGGRCKDL VNGFTCICLQ GFSGVFCEMD IDFCEPNPCR NGAKCYDLGG DYYCACPDDY
DGKNCSHLKD HCKNNSCKVI DSCTIEVFTN ATQGGIRFIS SNVCGPHGRC ISQPGGNFTC
ACERGFTGIY CHENINDCLG KPCKNGGTCI DEVDSFRCFC SSGWEGELCD TNFNDCSPNP
CHNGGRCIDL VNDFYCECKN DWKGKTCHSR EYQCDANTCS NGGTCYDDGD TFRCSCPPEW
IGSTCNIAKN SSCIPNPCMN GGTCVGSGDS FSCICKEGWE GRTCTQNTND CNPHPCYNGG
ICVDGVNWFR CECAPGFAGP DCRINIDECQ SSPCGYGATC IDEINGYRCT CPPGRVGPRC
QEVIGIGKPC WLKGMTFPHG SRWDQECNNC HCLDGRIDCT KVWCGKKPCL LQKHWDNANN
QCPMGQECQE KYMKCFQPPC TDWGECSASE PLPANIKCLP NSGYLDNDCA RITLIFNGDK
VPQGTTTENI CSEIRYLPAT RTVSRDRTLI ILCDLSYSTE NAVEVAISFV PHQDEQDNSL
IQSAANTIVN AITKRQNSTV MLAVTEVKVE TIVVGNSSSD YLVPILCAVF SIVWLTCIII
CVWWTRKRRK ERERSRPPRE EGANNQWAPL NPIRNPIDRS YSNKDIRYEC KNFIAPQKRT
CDAVEEYVEY EEEEDEDEER DEEMDKFLSH KLAKPLPTKA PDTSESSPVK KSHQIGKMDN
RSVKNVNASN FEGSRD
//
