ID A0A093KWW1_FULGA Unreviewed; 2748 AA.
AC A0A093KWW1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Neurofibromin {ECO:0000313|EMBL:KFW01856.1};
DE Flags: Fragment;
GN ORFNames=N327_04427 {ECO:0000313|EMBL:KFW01856.1};
OS Fulmarus glacialis (Northern fulmar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Procellariiformes; Procellariidae;
OC Fulmarus.
OX NCBI_TaxID=30455 {ECO:0000313|EMBL:KFW01856.1, ECO:0000313|Proteomes:UP000053806};
RN [1] {ECO:0000313|EMBL:KFW01856.1, ECO:0000313|Proteomes:UP000053806}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N327 {ECO:0000313|EMBL:KFW01856.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KK593774; KFW01856.1; -; Genomic_DNA.
DR Proteomes; UP000053806; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd13313; PH_NF1; 1.
DR CDD; cd05130; RasGAP_Neurofibromin; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053806}.
FT DOMAIN 1210..1405
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1534..1692
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW01856.1"
FT NON_TER 2748
FT /evidence="ECO:0000313|EMBL:KFW01856.1"
SQ SEQUENCE 2748 AA; 310084 MW; C3B581C4440B410F CRC64;
LPIKAGQQNT HTKVSTEHNK ECLINISKYK FSLVISGLTN ILKNVNNMRI FGETAEKNLY
LSQLIILDTL EKCLAGQPKD TMRLDETMLV KQLLPEICHF IHTYREGNQH AAELRNSASG
VLFSLSCNNF NAVFSRISTR LQELTVCSED NADVHDIELL QYISVDCSKL KRLLQETVFK
FKALKKVAQL AVINSLEKAF WNWVENYPDE FTKLYQTPQT DMADCAEKLF DLVDGFAEST
KRKAAVWPLQ IILLVLCPEI IQDIAKDVVE ETKMNKKLFL DNLRKALAGH SGSRQLTESA
AIACVKLCKA STYINWEDNS VIFLLVQSMV VDLKNLLFNP SKPFSRGNQN ADVDLMIDCL
VSCFRINPHN NQHFKICLAQ NSPSTFHYVL VNSLHRIITN SALDWWPKID AVYCHSMELR
SMFSETLHKA IQGCGAHPAI RMTPSLTFKE KMTSLKFKEK PTDLETRSYK FLLLSLVKLI
HADPKLLLCN PRKQGPETQG STAELITGLV QLVPQSSMPE IAQEAMEALL VLHQLDSIDL
WNPDAPIETF WEISSQMLFY ICKKLTSHQM LSSTEILKWL REILICRNKF LLKNKQSDRS
SCHFLFLYDV SGGGTSQISL DHEEMIRCAP GATLRKGKGN SSMESTAGCS GTPICRQAQT
KLEVALYMFL WSPDIEAVLV AMSCFRHLCE EADIRCGVDE VSVHNFLPNY NTFMEFASVS
NMMSTGRAAL QKRVMALLRR IEHPTAGNTE AWEDTHAKWE QATKLILNYP KTKMEDGQVT
ESLHKTIVKR RMSHVSGGGS IDLSDTDSLQ EWINMTGFLC ALGGVCLQHR SNAGLATYSP
PMGPVNERKG SMISMVSTEG NAETPVSKFI DRLLTLMVCN HEKVGLQIRT NIKDLVGLEL
SPALYPMLFN KLKNTISKFF DSQGQVLLTE TNTQFVEQTI AIMKNLLDNH TEGSSEHLGQ
ASIETMMLNL VRYVRVLGNL VHAIQIKTKL CQLVEVMMER RDDLSFCQEM KFRNKMVEYL
TDWVMGTSNQ ATDEDVKCLT RDLDQASMEA VVSLLAGLPL QPEEGDGVEL MEAKSQLFLK
YFTLFMNLLN DCSEVEDESA QTGGRKRGMS RRLASLRHCT VLAMSNLLNA NVDSGLMHSI
GLGYHKDLQT RATFMEVLTK ILQQGTEFDT LAETVLADRF ERLVELVTMM GDQGELPIAM
ALANVVPCSQ WDELARVLVT LFDSRHLLYQ LLWNMFSKEV ELADSMQTLF RGNSLASKIM
TFCFKVYGAT YLQKLLEPLL RTVITSSEWQ HVSFEVDPTR LEPTESLEEN QRSLLQMTEK
FFHAIINSSS EFPPQLRSVC HCLYQVVSQR FPQNSIGAVG SAMFLRFINP AIVSPYEAGI
LDKKPPPRIE RGLKLMSKIL QSIANHVLFT KEEHMRPFND FVKSNFDAAR RFFLDIASDC
PASDTVNHSL SFISDGNVLA LHRLLWNNQE KIGQYLSSNR DHKAVGRRPF DKMATLLAYL
GPPEHKPVAD THWSSLNLTS SKFEEFMTRH QVHEKEEFKA LKTLNIFYQA GTSKAGNPVF
YYIARRFKTG QINGDLLIYH VLLTLKPYYA KPYEIVVDLT HAGPSNRFKT DFLSKWFVVF
PGFAYENVSA VFIYNCNSWV REYTKYHERL LTGLKGSKRL IFIDSPGKLA EHIEHDQQKL
PAATLALEED LKVFHNALKL AHKDTKVSIK VGSTAVQVTS AERTRVLGQT VFLNDIYYAS
EIEEICLVDE NQFTLTIANQ GTPLTFMHQE CEAIVRSIIH IRTRWELSQP DSIPQHTKIR
PKDVPGTLLN IALLNLGSSD PSLRSAAYNL LCALTCTFNL KIEGQLLETS GLCIPANNTL
FIVSISKTLA ANEPHLTLEF LEECISGFSK SSIELKHLCL EYMTPWLSNL VRFCKHNDDA
KRQRVTAILD KLITMTINEK QMYPSIQAKI WGSLGQITDL LDVVLDSFIK TSATGGLGSI
KAEVMADTAV ALASGNVKLV SSKVIGRMCK IIDKTCLSPT PTLEQHLMWD DIAILARYML
MLSFNNSLDV AAHLPYLFHV VTLLVATGPL SLRASTHGLV INIIHSLCTC SQLHFSEETK
QVLRLSLTEF SLPKFYLLFG ISKVKSAAVI AFRSSYRDRS FSPGSYERET FALTSLETVT
EALLEIMEAC MRDIPTCKWL DQWTELAQKF AFQYNPSLQP RALVVFGCIS KRVSHGQIKQ
IIRILSKKKG LESCLKGPDN YNSQVLIEAT VIALTKLQPL LNKDSPMHKA LFWVAMAVLQ
LDEVNLYSAG TALLEQNLHT LDSLRVFNDK SPEEVFMEIR RPLEWHCKQM DHFVGLNFNS
NFNFALVGHL LKGYRHPSPT TVARTVRILH TLLALVNKHR NCDKFEVNTQ SVAYLAALLT
VSEEVRSRCS LKHRKSLLLT DISMENVPMD TYPIHHSDTS YRTLKENQPW SSPKGSDRHL
AASYPTVGQI SPRTRKSMSL DMGQPSQANT KKLLGTRKSF DHLISDTKAP KRQDMESGIT
TPPKMRRVAE NDYEMETQRI SPQQHPHLRK VSVSESNVLL DEEVLTDPKI QALLLTVLAT
LVKYTTDEFD QRILYEYLAE ASVVFPKVFP VVHNLLDSKI NTLLSLCQDP NLLNPIHGIV
QSVVYHEESP PQYQTSYLQS FGFNGLWRFA GPFSKQTQIP DYAELIVKFL DALIDTYLPG
IDEETSEESL LTPTSPYPPA VQSQLSITAN LNLSNSMTSL ATSQHSPG
//
