ID A0A093PBH7_PHACA Unreviewed; 942 AA.
AC A0A093PBH7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=Rap guanine nucleotide exchange factor 4 {ECO:0000313|EMBL:KFW73776.1};
DE Flags: Fragment;
GN ORFNames=N336_06284 {ECO:0000313|EMBL:KFW73776.1};
OS Phalacrocorax carbo (Great cormorant) (Pelecanus carbo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Suliformes; Phalacrocoracidae;
OC Phalacrocorax.
OX NCBI_TaxID=9209 {ECO:0000313|EMBL:KFW73776.1, ECO:0000313|Proteomes:UP000053238};
RN [1] {ECO:0000313|EMBL:KFW73776.1, ECO:0000313|Proteomes:UP000053238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N336 {ECO:0000313|EMBL:KFW73776.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KL411824; KFW73776.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093PBH7; -.
DR Proteomes; UP000053238; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 2.
DR CDD; cd04437; DEP_Epac; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.8.1240; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF175; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR Pfam; PF00027; cNMP_binding; 2.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR PRINTS; PR00103; CAMPKINASE.
DR SMART; SM00100; cNMP; 2.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000053238}.
FT DOMAIN 22..125
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 196..271
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 336..437
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 476..625
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 763..942
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW73776.1"
FT NON_TER 942
FT /evidence="ECO:0000313|EMBL:KFW73776.1"
SQ SEQUENCE 942 AA; 107991 MW; DC830319A6EB7CA3 CRC64;
RPLERSSEDV DIIFTRLKEV KAFEKFHPNL LQQICLCGYY ENLEKGITLF RQGDIGTNWY
AVLTGSLDVK VSDTSNHQDA VTICTLGIGT AFGESILDNT PRHATIVTRE FSELLRIEQK
DFKALWEKYR QYMSGLLTPP YGVMETSSNN DKVTDRRNKT PLIEPHIPHR PTKTITQVPS
EKILRAGKIL RNTILSRAPH MIRDRKYHLK TYRQCCVGTE LVDWMMQQSP CVHSRTQAVG
MWQVLLEEGV LNHVDQEHHF QDKYLFYRFL DDEREDAPLP TEEEKKECDE ELQDTMLLLS
QIGPDAHMRM ILRKPPGQRT VDDLEIIYEE LLHIKALSHL STTVKRELAG VLIFESHPKA
GTVLFNQGEE GTSWYIILKG SVNVVIYGKG VVCTLHEGDD FGKLALVNDA PRAASIVLRE
DNCHFLRVDK EDFNRILRDV EANTVRLKEH DQDVLVLEKI PAGNRVSNQG NSQPQHKYIV
MSGTPEKILE HFLETMRPEA TLNEGTDSVL SDFIMMHCVF MPNSQLCPAL MAQYPFLREK
HRGTYHAQPS QGTEQEKMDY ALNNKRRVIR LVLQWAALYG DLLQEDEAAM AFLEEFYVSV
SDDTRMIAAL KEQLPELEKI VKQVSEEPKA PQKKHKVLLQ LFNTSDDRSQ KRQPIRGSDE
VLFKVYCIDQ TYTTIRVPVS SSVKEVISAV ADKLGSGEGL IIVKMSSGGE KVVLKPHDVS
VFTTLSVNGR LFACPRDQFD SLAPLPEQEG PSTGTVGTFE LMSSKDLAHQ MTIYDWELFN
CVHELELIYH TFGRHNFKKT TANLDLFLRR FNEIQFWVVT EICLCSQLSK RVQLLKKYIK
IAAHCKEYKN LNSFFAIIMG LSNVAVSRLS LTWEKLPSKF KKIYAEFESL MDPSRNHRAY
RLTVAKLDPP IIPFMPLLIK DMTFTHEGNK TFTDNLVNFE KM
//