ID A0A093PRC8_9PASS Unreviewed; 177 AA.
AC A0A093PRC8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Insulin-like growth factor II {ECO:0000313|EMBL:KFW79393.1};
DE Flags: Fragment;
GN ORFNames=N305_09802 {ECO:0000313|EMBL:KFW79393.1};
OS Manacus vitellinus (golden-collared manakin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Pipridae; Manacus.
OX NCBI_TaxID=328815 {ECO:0000313|EMBL:KFW79393.1, ECO:0000313|Proteomes:UP000053258};
RN [1] {ECO:0000313|EMBL:KFW79393.1, ECO:0000313|Proteomes:UP000053258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N305 {ECO:0000313|EMBL:KFW79393.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR EMBL; KL670495; KFW79393.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093PRC8; -.
DR STRING; 328815.ENSMVIP00005014552; -.
DR Proteomes; UP000053258; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR CDD; cd04368; IlGF; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR022334; IGF2.
DR InterPro; IPR013576; IGF2_C.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR022350; Insulin-like_growth_factor.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR46886; INSULIN-LIKE GROWTH FACTOR II; 1.
DR PANTHER; PTHR46886:SF1; INSULIN-LIKE GROWTH FACTOR II; 1.
DR Pfam; PF08365; IGF2_C; 1.
DR Pfam; PF00049; Insulin; 2.
DR PRINTS; PR02002; INSLNLIKEGF.
DR PRINTS; PR02006; INSLNLIKEGF2.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR622350-50};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Reference proteome {ECO:0000313|Proteomes:UP000053258};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..177
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001886824"
FT DOMAIN 19..74
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
FT REGION 154..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 22..61
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 34..74
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 60..65
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW79393.1"
FT NON_TER 177
FT /evidence="ECO:0000313|EMBL:KFW79393.1"
SQ SEQUENCE 177 AA; 19668 MW; B3EC12BB0C532A99 CRC64;
LLAFLAYALD SAAAYGTAET LCGGELVDTL QFVCGDRGFY FSRPVGRNNR RINRGIVEEC
CFRSCDLALL ETYCAKSVKS ERDLSATSLS GLPALGKESF QKPSHAKYSK YDVWQKKSSQ
RLQREVPSIL RARQYRWQAE GLQAAEEAKV LHRPLISLPS QRPPAVRASP ETAGPQK
//
