ID A0A093Q7B1_PHACA Unreviewed; 1172 AA.
AC A0A093Q7B1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Rap guanine nucleotide exchange factor 1 {ECO:0000313|EMBL:KFW84863.1};
DE Flags: Fragment;
GN ORFNames=N336_09919 {ECO:0000313|EMBL:KFW84863.1};
OS Phalacrocorax carbo (Great cormorant) (Pelecanus carbo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Suliformes; Phalacrocoracidae;
OC Phalacrocorax.
OX NCBI_TaxID=9209 {ECO:0000313|EMBL:KFW84863.1, ECO:0000313|Proteomes:UP000053238};
RN [1] {ECO:0000313|EMBL:KFW84863.1, ECO:0000313|Proteomes:UP000053238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N336 {ECO:0000313|EMBL:KFW84863.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL417781; KFW84863.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093Q7B1; -.
DR Proteomes; UP000053238; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000053238}.
FT DOMAIN 780..905
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 935..1159
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 122..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 174..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 615..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..203
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW84863.1"
FT NON_TER 1172
FT /evidence="ECO:0000313|EMBL:KFW84863.1"
SQ SEQUENCE 1172 AA; 130376 MW; 847917833BCE5150 CRC64;
NVSWLEEKEK EVVSALRYFK TIVDKMAIDK KVLEMLPGSA SKVLEAILPL VQTDPRIQQS
SAISSCYSRV YQSLANLIRW SDQVMLEGVN SEDKEMVTTV KDVIKAVLDG VKELVRLTIE
KQEHPSPTSP VKASLPACKS DSPSELPLTD REMEILNKTT NMTQSNELLT DSMDEEVAPP
KPPLPSIRVA ENSPPPALPP KKRQSAPSPT RVAVVAPMSR ATSGSSLPVG INRQDFDVDC
YAQRRLSGGS HSYGGESPRL SPCSSIGKLS KSDEQLSSLD RDSGQCSRNT SCETLDQSDH
YDPDYEFLQQ DLSNADQIPQ QVPGILSPLP ESLGESGSPF HGHAFQLPQG SSPPLEFCSL
SGAAQPTETP PALPEKKRRS AASQTSDNSG CRVSYERHPS QYDNISEDDV KNAASVPFAP
FAAVLPFQQG NSSAPVEFIA DFAAPDSNSD PEKPPPLPEK KNKNMMAYMQ FVEDYSEPQP
SMFYQTPQNE HIYQQKNKHL MEVYGFNDSF TSLDASQDLA PPPALPPKQR QLQASYAASS
FSSVSYCVQQ TKVPFTPEDT GATQGLTMSV SNSFLNRHSS FPVHSYKSVF RSYSQDFVPH
NQVSIPPFLS STSSSCSTPP FPPVHPSQSS VLAVPAAASQ SPSTVDVPNS SSQESSFNGN
APVCLPSETS FTDSLQTPSS ENASEEAGEG EYVNLYSSGQ SNGELPRSEG ESPPVKDGHS
KDSSANSSAM GKEGKDGAER QQQSPDALES SQLEEEVDEL SLIDHSEIMA RLTLKQEGDD
GPDVRGGSGD ILLVHATETD RKDLVLYCEA FLTTYRTFIT PEELIKKLQY RYPFAGKFCH
FPDTFKKRVS KNTFFVLVRV VDELCLVELT EEILKLLMDL VFRLVCNGEL SLARVLRKNI
LDKVDQKKTL SYANSIKPLA ARGVAARPGT LHDFHSHEIA EQLTLLDAEL FYKIEIPEVL
LWAKEQNEEK SPNLTQFTEH FNNMSYWVRS IIMLQEKGQD RERLLLKFIK IMKHLRKLNN
FNSYLAILSA LDSAPIRRLE WQKQTSEGLA EYCTLIDSSS SFRAYRAALA DVEPPCIPYL
GLILQDLTFV HLGNPDYIDS KVNFSKRWQQ FNILDSMRCF QQVHYDIKRN DDIVSFFNDF
SDHLAEEALW ELSLKIKPRN ITRRKTDREE KT
//
