ID A0A093QC79_9PASS Unreviewed; 662 AA.
AC A0A093QC79;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Zinc transporter ZIP12 {ECO:0000256|ARBA:ARBA00040591};
DE AltName: Full=Solute carrier family 39 member 12 {ECO:0000256|ARBA:ARBA00042541};
DE AltName: Full=Zrt- and Irt-like protein 12 {ECO:0000256|ARBA:ARBA00042971};
DE Flags: Fragment;
GN ORFNames=N305_13891 {ECO:0000313|EMBL:KFW86141.1};
OS Manacus vitellinus (golden-collared manakin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Pipridae; Manacus.
OX NCBI_TaxID=328815 {ECO:0000313|EMBL:KFW86141.1, ECO:0000313|Proteomes:UP000053258};
RN [1] {ECO:0000313|EMBL:KFW86141.1, ECO:0000313|Proteomes:UP000053258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N305 {ECO:0000313|EMBL:KFW86141.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351,
CC ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00034634};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000256|ARBA:ARBA00006939}.
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DR EMBL; KL672544; KFW86141.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093QC79; -.
DR STRING; 328815.ENSMVIP00005008711; -.
DR Proteomes; UP000053258; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR003689; ZIP.
DR InterPro; IPR049406; ZIP4_12_EF-hand.
DR InterPro; IPR041137; ZIP4_N.
DR PANTHER; PTHR12191; SOLUTE CARRIER FAMILY 39; 1.
DR PANTHER; PTHR12191:SF4; ZINC TRANSPORTER ZIP12; 1.
DR Pfam; PF21116; EF-hand_Zip; 1.
DR Pfam; PF02535; Zip; 1.
DR Pfam; PF18292; ZIP4_domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053258};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..662
FT /note="Zinc transporter ZIP12"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001889685"
FT TRANSMEM 380..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 410..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 457..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 613..635
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 641..658
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 67..225
FT /note="Zinc transporter ZIP4 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18292"
FT DOMAIN 233..359
FT /note="Zinc transporter ZIP4/12 EF-hand"
FT /evidence="ECO:0000259|Pfam:PF21116"
FT REGION 507..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 662
FT /evidence="ECO:0000313|EMBL:KFW86141.1"
SQ SEQUENCE 662 AA; 73714 MW; 8B079B0E699A8AFE CRC64;
MCFLTKPSAL GVVCSAFIFS VLIAEGQPGE EHGQDGSYAP SRGYLMEVLR VLSAENTELH
MNHSRELVKM LLERAECPQR IYGMQEDCNM CLEPDALLLV AGGDLEDHLS EEVFERISLI
LLYYILHRRD VCSPELSLNN KDYKFYLQSM LSLRHDEDCY YFSRNETEDI LTAVRQHFKT
SETQCVDVST LEKNADITDR DGADENTLPR LAALIITLAL QGVCMGKASL PSPEFFIKYI
FSSLNSTTEL QVTELEQLLN VLTAKKTCTV NGQFHSHKRR RYSMAIRDTG RKNSPFKGNH
TKGDSLKGYF EDRERNTDWD QVCFSANELV KIFLKNGSSS ISKDHFKQIS PAIIQQLLSC
SCQLPDFKQT RLPPTTVEKY GYSTVAVLLI TIGSMFGTTL ILFNSCQEIY TLVLQLFVGL
AVGTLSGDAL LHLIPQTLGL HKHEAQDIEH FYEGKEYIWK LLGIIGGIHG FFLIEKCFFL
LVTPREQQGL SLVNGHWGHS HDLPVESELN EHSGRGKSTS TIQLRSPEDS ESAEVPPESK
AISKKSKKIS LLAIMVLVGD SLHNFADGLV IGAAFSSSTE TGVTTTVAIL CHEIPHEMGD
FAVLLSTGLP TKIAILMNFI SALTAFLGLY IGLSLSTDPS IQNWIFTVTA GMFLYLSLAE
MV
//