ID A0A093QPM4_9PASS Unreviewed; 428 AA.
AC A0A093QPM4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Dorsalin-1 {ECO:0000313|EMBL:KFW85917.1};
GN ORFNames=N305_11435 {ECO:0000313|EMBL:KFW85917.1};
OS Manacus vitellinus (golden-collared manakin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Pipridae; Manacus.
OX NCBI_TaxID=328815 {ECO:0000313|EMBL:KFW85917.1, ECO:0000313|Proteomes:UP000053258};
RN [1] {ECO:0000313|EMBL:KFW85917.1, ECO:0000313|Proteomes:UP000053258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N305 {ECO:0000313|EMBL:KFW85917.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; KL672532; KFW85917.1; -; Genomic_DNA.
DR RefSeq; XP_008928062.1; XM_008929814.2.
DR AlphaFoldDB; A0A093QPM4; -.
DR STRING; 328815.ENSMVIP00005024228; -.
DR GeneID; 103763099; -.
DR CTD; 2658; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000053258; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19400; TGF_beta_BMP9; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF157; GROWTH_DIFFERENTIATION FACTOR 2; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000053258};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..428
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001886706"
FT DOMAIN 316..428
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 288..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..311
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 428 AA; 48444 MW; 0F00147297B3BFDE CRC64;
MHCFGVLAAL SVFNIIACLT RGKPLEDWDK LSAMGKSDAH FHDPGEVEDE SHFDFKSFLE
NMKTDLQRSL NLSRIPSQVK TKEEPPQFMI DLYNRYAADK SSIPASNIVR SFSTEDVVSL
DSPEENPFQK HILFFNISIP QYEEITRAEL RIYVSCHREA ESLSRLEGTM VIYDVLDDGH
WENPESTKSF LVSHSIQKCG WEMFEVSSAV KRWVRADKLK TKNKLEVVIE SKVLSGFTCE
KLDISVAPDA KNLPLLMVFS NDRSNGTKET KVELREMIVH EQESVLKKLG KNNTSSEEDE
QGEEKAITGP HQHSSRSKRS VGANHCRRTS LHVNFEEIGW DSWIIAPKDY EAFECKGGCF
FPLTDNVTPT KHAIVQTLVH LQNPKKASKA CCVPTKLDSI SILYKDDAGV PTLIYNYEGM
KVAECGCR
//
