ID A0A093QWZ3_PHACA Unreviewed; 587 AA.
AC A0A093QWZ3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE SubName: Full=Rho GTPase-activating protein 42 {ECO:0000313|EMBL:KFW88457.1};
DE Flags: Fragment;
GN ORFNames=N336_09718 {ECO:0000313|EMBL:KFW88457.1};
OS Phalacrocorax carbo (Great cormorant) (Pelecanus carbo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Suliformes; Phalacrocoracidae;
OC Phalacrocorax.
OX NCBI_TaxID=9209 {ECO:0000313|EMBL:KFW88457.1, ECO:0000313|Proteomes:UP000053238};
RN [1] {ECO:0000313|EMBL:KFW88457.1, ECO:0000313|Proteomes:UP000053238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N336 {ECO:0000313|EMBL:KFW88457.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KL420572; KFW88457.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093QWZ3; -.
DR Proteomes; UP000053238; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01249; BAR-PH_GRAF_family; 1.
DR CDD; cd12066; SH3_GRAF3; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047234; GRAF_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047225; PH_GRAF.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12552; OLIGOPHRENIN 1; 1.
DR PANTHER; PTHR12552:SF3; RHO GTPASE-ACTIVATING PROTEIN 42; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000053238};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 66..175
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 188..372
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 529..587
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 375..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 26..60
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 417..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..523
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW88457.1"
FT NON_TER 587
FT /evidence="ECO:0000313|EMBL:KFW88457.1"
SQ SEQUENCE 587 AA; 66312 MW; C1550F16209FD0DA CRC64;
LLAFLQGLFT FYHEGYELAQ EFAPYKQQLQ FNLQNTRNNF ESTRQEVERL MQRMKSANQD
YRPPSQWTME GYLYVQEKRP LGFTWVKHYC TYDKGTKTFT MSIAETKSGG KVNGLVTSPP
EIFKLKSCIR RKTDSIDKRF CFDIEVFERP GIITLQAFSE SNRKLWLEAM DGKEPVRIFF
SFFFSFYMFL NEAGFNFVRK CIHAVETRGI TILGLYRIGG VNSKVQKLMN TIFSPKSPPD
MDIDMELWDN KTITSGLKNY LRCLSEPLMT FKLHKDFIVA VKSDDQNYRV EAVHALVHKL
PEKNREMLDI LIKHLVKVSL HSQQNLMTVS NLGVIFGPTL MRAQEETVAA MMNIKFQNVV
VEILIEHYEK IFHTAPDPNI PLPQPQSRSG SRRTRAICLS TGSRKPKGRY TPCLADPDSD
SYSSSPDSTP MGSIESLSSH SSEQNSTTKC APSQPREKSG GIPWIASPPS SNGQKGSGLW
TTSPESSSKE DATKTDVESD CQSVASVTGQ ENASPPTDLT KKTSYSLSGL KRQAKAMYSC
KAEHSHELSF PQGAIFSNVY PSVEPGWLKA TYEGKTGLVP ENYVVFL
//
