ID   A0A093R0Y7_PHACA        Unreviewed;       638 AA.
AC   A0A093R0Y7;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Choline O-acetyltransferase {ECO:0000256|ARBA:ARBA00040495};
DE            EC=2.3.1.6 {ECO:0000256|ARBA:ARBA00039091};
DE   Flags: Fragment;
GN   ORFNames=N336_12611 {ECO:0000313|EMBL:KFW92315.1};
OS   Phalacrocorax carbo (Great cormorant) (Pelecanus carbo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Suliformes; Phalacrocoracidae;
OC   Phalacrocorax.
OX   NCBI_TaxID=9209 {ECO:0000313|EMBL:KFW92315.1, ECO:0000313|Proteomes:UP000053238};
RN   [1] {ECO:0000313|EMBL:KFW92315.1, ECO:0000313|Proteomes:UP000053238}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N336 {ECO:0000313|EMBL:KFW92315.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the reversible synthesis of acetylcholine (ACh)
CC       from acetyl CoA and choline at cholinergic synapses.
CC       {ECO:0000256|ARBA:ARBA00037088}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + choline = acetylcholine + CoA;
CC         Xref=Rhea:RHEA:18821, ChEBI:CHEBI:15354, ChEBI:CHEBI:15355,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.6;
CC         Evidence={ECO:0000256|ARBA:ARBA00036720};
CC   -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
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DR   EMBL; KL433835; KFW92315.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A093R0Y7; -.
DR   Proteomes; UP000053238; Unassembled WGS sequence.
DR   GO; GO:0004102; F:choline O-acetyltransferase activity; ISS:AgBase.
DR   GO; GO:0060416; P:response to growth hormone; ISS:AgBase.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR   InterPro; IPR000542; Carn_acyl_trans.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR039551; Cho/carn_acyl_trans.
DR   InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR   PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR   PANTHER; PTHR22589:SF14; CHOLINE O-ACETYLTRANSFERASE; 1.
DR   Pfam; PF00755; Carn_acyltransf; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR   PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW   ECO:0000256|RuleBase:RU003801};
KW   Neurotransmitter biosynthesis {ECO:0000256|ARBA:ARBA00022979};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053238};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801}.
FT   DOMAIN          25..604
FT                   /note="Choline/carnitine acyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00755"
FT   ACT_SITE        333
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFW92315.1"
FT   NON_TER         638
FT                   /evidence="ECO:0000313|EMBL:KFW92315.1"
SQ   SEQUENCE   638 AA;  72444 MW;  66958646652FCF20 CRC64;
     PVLEKNMQKK EKDACSKDET AVPKLPVPPL QQTLRMYLQC MKHLVPEEQF RKTKVIVEQF
     GIAGGLGESL QQILEERREK TTNWVFNYWL DDMYLNNRLA LPVNSSPAII FARQYFKDVN
     DQLRFAANLI SGVQDYKALL DTHALPVDFA RGQLSGHPLC MKQYYGLFSS YRLPGHTKDT
     LVAQKSSVMP EPEHIIVACN NQFFVLDVVI NFRRLSEGDL FTQLRKIAKM AENEEEMLPP
     IGLLTTDGRT EWAEARTILM KDSTNRDSLD MIERCICLVC LDSPSGVELN DTNMALQLLH
     GGGYHKNGAN RWYDKPMQFV VGRDGVCGTV CEHSPFDGIV LVQCTEHLLR HMKESSKKLV
     RADSVSELPA PRRLRWKCSP EIQAHLASSA EKLQRIVKNL DFIAYKFENY GKEFIKKQKI
     SPDAYIQVAL QLAFYRCHGR LVPTYESASI RRFDEGRVDN IRSATLEAFA FVKAMTDDKR
     ALSDSEKMER FKDAVTAQTN YTILAITGMA IDNHLLGLRE VAREHFKELP EIFTDETYLT
     SNRFILSTSQ VPTTTEMFCC YGPVVPNGYG ACYNPQPEHI LFCISSFKDC KETSSDGFAK
     AVEESLLEMR DLCSKCNSTV AKPLAKQEAA AQLQSDRK
//