ID   A0A093S662_9PASS        Unreviewed;       361 AA.
AC   A0A093S662;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
DE   Flags: Fragment;
GN   ORFNames=N305_04296 {ECO:0000313|EMBL:KFW78414.1};
OS   Manacus vitellinus (golden-collared manakin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Pipridae; Manacus.
OX   NCBI_TaxID=328815 {ECO:0000313|EMBL:KFW78414.1, ECO:0000313|Proteomes:UP000053258};
RN   [1] {ECO:0000313|EMBL:KFW78414.1, ECO:0000313|Proteomes:UP000053258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N305 {ECO:0000313|EMBL:KFW78414.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-
CC         (2->8)- glycosidic linkages of terminal sialic acid residues in
CC         oligosaccharides, glycoproteins, glycolipids, colominic acid and
CC         synthetic substrates.; EC=3.2.1.18;
CC         Evidence={ECO:0000256|ARBA:ARBA00000427};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC       {ECO:0000256|ARBA:ARBA00009348}.
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DR   EMBL; KL670098; KFW78414.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A093S662; -.
DR   Proteomes; UP000053258; Unassembled WGS sequence.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF23; SIALIDASE-3; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   3: Inferred from homology;
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022963};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053258}.
FT   DOMAIN          27..336
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFW78414.1"
FT   NON_TER         361
FT                   /evidence="ECO:0000313|EMBL:KFW78414.1"
SQ   SEQUENCE   361 AA;  39220 MW;  8C92BD5A0A4E67FA CRC64;
     ETLFRQGSGV TYRIPALLYI PPDESFLAFA EKRSSARDED AKYLVLRRGC QHGSSVKWGP
     VEELSALALP GRRTMNPCPL FDARSGTIFL FCICVEQGKT EQHQIWRGCS AARLCFATSA
     DGGRSWAPLR DVTDEAVGAD LSRWATFAVG PGHGIQLDSG RLVVPAYTYY MHGSLCGAAR
     LPCSTRQHSL VFYSDDGGRR WHKGALLAGE RTGECQVAEI HGAHPPLLYC SARAPRGCRA
     VALSTDRGLR FQRPTRCPVL AEPPHGCQGS VVSFAAPAST AGAPTWLLYS HPTSRHHRRD
     LGVYVNPSPL DGAGWRRPWV LHAGPAGYSD LAVCPGRIFG CLFECGTASA CEEIVFCLFT
     L
//