ID A0A093SUC3_9PASS Unreviewed; 1975 AA.
AC A0A093SUC3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Rho GTPase-activating protein 21 {ECO:0000313|EMBL:KFW86119.1};
DE Flags: Fragment;
GN ORFNames=N305_13868 {ECO:0000313|EMBL:KFW86119.1};
OS Manacus vitellinus (golden-collared manakin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Pipridae; Manacus.
OX NCBI_TaxID=328815 {ECO:0000313|EMBL:KFW86119.1, ECO:0000313|Proteomes:UP000053258};
RN [1] {ECO:0000313|EMBL:KFW86119.1, ECO:0000313|Proteomes:UP000053258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N305 {ECO:0000313|EMBL:KFW86119.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Cytoplasmic
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004284}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004284}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004395}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004395}.
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DR EMBL; KL672544; KFW86119.1; -; Genomic_DNA.
DR STRING; 328815.ENSMVIP00005009241; -.
DR Proteomes; UP000053258; Unassembled WGS sequence.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01253; PH_ARHGAP21-like; 1.
DR CDD; cd04395; RhoGAP_ARHGAP21; 1.
DR Gene3D; 1.20.5.220; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23175; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23175:SF16; RHO GTPASE-ACTIVATING PROTEIN 21; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000053258}.
FT DOMAIN 29..125
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 937..1046
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1153..1345
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 659..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 864..893
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 906..934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1093..1131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1376..1407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1425..1524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1538..1574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1619..1703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1715..1773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1834..1853
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1879..1975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..934
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1101..1126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1382..1406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1433..1521
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1627..1650
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1670..1687
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1715..1745
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1910..1953
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW86119.1"
FT NON_TER 1975
FT /evidence="ECO:0000313|EMBL:KFW86119.1"
SQ SEQUENCE 1975 AA; 220524 MW; 79873A1801F22CFA CRC64;
SKNKDGKEQS EAISPSEEEE TFSWPGPKTV VLRRTSQGFG FTLRHFIVYP PESAVQFSFK
DEENGNRQGK QRNRLEPMDT IFVKQVKEGG PAFEAGLCTG DRIIKVNGES VIGKTYSQVI
ALIQNRDSVN FELVFPLLKI DHANTGWRTF LSPSLLNTHL ILSPQAYSQD AYLKGNEAYS
GNAHNIPEPP PICYPRLTST ASVKAQAADK LSSDFSLGKQ QVSRPVRALT QPERAYRMEI
QVPPSPTDIA KSNTAVCVCN ETVRTVIVPS EKAVDLPSCR NNHAGPSHRT EEVRYGLKDQ
TSLKARTTSP SSSVSTAIVL PQTPITRPVD TTGAVSKASN YVVCPEGIPS TRPPAQATDS
PSVSTNHYSS PTSHQHIDWK TYKTYKEYID NRRMHMYGSR TIQERLDSLR AASQNTTDYN
QVVPNRTASQ VRRRSTSHDR VPQSVQIRQR SVSQERLEDP VLMKEWPRSA SQDTLTSPSV
NARNHRARSW DYLSKQGEVL ENFHSDNMIA DTNGDRRKTY KWTGFTEQDD RRGIYERSRQ
HAFHMSLRGQ NFPIAPSAYI SDNRRTGSRA SLPGSHFQKI SPDFKMLQPS RDLQTPGGVS
KPAAVSQERL CLTPARSSRS SSLKNSAPYA AKPSIPLNQG LDAIASKDQR TVNHLHQSGL
LNQQSRIRAE GAQDHKTETG KTIQPSSLSP ASAKLVQPSE CSTTSDNVDG SIRQKIHFER
EDVRESESLQ TDVQGNDKDT VVMRDKSPSG HQTPQPLRHQ SYILAVNDQE AASDTTCWLP
NDARREVHIK RIEERKASGS SPPGDSLASI PFIDEPTSPS IDHDIAHIPA SAVISASASQ
APAITTVPPS PTSPIPLIRR QLSHDHESMR PSVLDSQPAA KTERSKSYDE GLDDYREEGK
SSIKHVSSLK GIKVPDSQKS SEDSGSRKDS SSEVFGDASK EGWLHFRQLV TDKGKRVGGS
IRPWKQLYVV LRGHSLYLYK DKKEQVTLSE EEQPISINAC LIDISYCETK RKNVFRLTTS
DCEYLFQAED RDNMLAWIKA IQDNSNLNDE DTGVTSRDLI SRRIKEYSTM MSKTEPSPKT
PRQSLSIRQT LLGTKAEQRT QSPHSPKDES ERKLLTKDET SPPKDKGTWR KGIPSIMRKT
FEKKPSAVGT FGVRLDDCPP AHTNKYIPLI VDICCKLVEE RGLEYTGIYR VPGNNAAISS
MQEELNKGMT DIDVHDDKWR DLNVISSLLK SFFRKLPEPL FTNDKYADFI DANRKEDPVE
RLKTLKRLIH DLPEHHYETL KFLSAHLKTV AENSEKNKME PRNLAIVFGP TLVRTSDDNM
THMVTHMPDQ YKIVETLIQK HDWFFTEDDA EEPLTAVQEE NTVESQPVPN IDHLLTNIGR
TGVSPGDVSD SATSDSAKSK GSWGSGKDQY SKELLVSSIF AAASRKRKKT KEKPQPSSSE
DELDNVFFKK ELAEQSRGDT TKEDTAKGEY EREREIGRKQ RMFVLKEKEN SSKKDVNVVK
DEKKSLKKES ILSEEPSLPY HEKCTKSSNL NCLQTMQKNN PKMPISQSSS QVEETVSDSG
TMLSTSSQAS QHRYSCKKVA SPEIKHNEFL AADVSSITSD YSTTSSTMYL TGLDASMLSP
EVQSVTESKG EDADDERSEL ISEGRPMETD SESDFPVFAT SAAAERLSKG KVSEVVKTSR
RNSEESEVSC TEGSSTPKLE SRRLFSSHKL IECDTLSRRK SARHKTDSEG SGDAKSEKDL
PTVTKMFDIM KKGRSTSSLA TSARSEADKQ EPTWRLKITD RLKLRLKSSA DDMFGVGNQK
TNSAETAKRK NIRRRHTLGG QRDFAEISVL NAWKAQEPSQ SRERESELSA VTRLKPKCPA
QDLSISDWLA RERLRTSTTD LNTGETGKPR LENTSLADVS KVDLPSSADM QADEGSSSSS
LTLINRTPPS GPFQPLDQVN GENYQNMNKN NFSPAVDAHP HKLSGTQVVR SRFYQ
//
