ID A0A093X8B4_9PEZI Unreviewed; 1682 AA.
AC A0A093X8B4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Clathrin heavy chain {ECO:0000256|PIRNR:PIRNR002290};
GN ORFNames=V490_07343 {ECO:0000313|EMBL:KFX88915.1};
OS Pseudogymnoascus sp. VKM F-3557.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1437433 {ECO:0000313|EMBL:KFX88915.1, ECO:0000313|Proteomes:UP000029320};
RN [1] {ECO:0000313|EMBL:KFX88915.1, ECO:0000313|Proteomes:UP000029320}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-3557 {ECO:0000313|EMBL:KFX88915.1,
RC ECO:0000313|Proteomes:UP000029320};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
CC coated pits and vesicles. {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFX88915.1}.
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DR EMBL; JPJS01002203; KFX88915.1; -; Genomic_DNA.
DR STRING; 1437433.A0A093X8B4; -.
DR HOGENOM; CLU_002136_0_0_1; -.
DR Proteomes; UP000029320; Unassembled WGS sequence.
DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR GO; GO:0071439; C:clathrin complex; IEA:InterPro.
DR GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.730; -; 1.
DR Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR016025; Clathrin_H-chain_N.
DR InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
DR InterPro; IPR016341; Clathrin_heavy_chain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10292:SF1; CLATHRIN HEAVY CHAIN; 1.
DR PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR Pfam; PF00637; Clathrin; 7.
DR Pfam; PF13838; Clathrin_H_link; 1.
DR Pfam; PF01394; Clathrin_propel; 2.
DR PIRSF; PIRSF002290; Clathrin_H_chain; 1.
DR SMART; SM00299; CLH; 7.
DR SUPFAM; SSF48371; ARM repeat; 6.
DR SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR PROSITE; PS50236; CHCR; 7.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|PIRNR:PIRNR002290};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|PIRNR:PIRNR002290}; Membrane {ECO:0000256|PIRNR:PIRNR002290};
KW Reference proteome {ECO:0000313|Proteomes:UP000029320}.
FT REGION 1623..1682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1637..1668
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1682 AA; 190171 MW; 5E547D9C00A009A6 CRC64;
MAALPIKFTE LLQLTSVGVE PASIGFNTCT LESDSFICVR EKKNEAASPE VVIIDLKQNN
NVTRRPIKAD SAIMHWTKQI IALKAQSRTL QIFDLEQKAK LKSATMNEDV VFWKWFNETT
LGLVTDTAVY HWDVFDQNQA QPVEVFKRHE NLQGSQIINY RVSADGKWMV VIGISQQQGR
VVGAMQLYSK DRGISQALEG HAAAFGTLRL EGAPADTKVF AFAVRTATGA KLHVVEVDHQ
ASNPAFPKKA VDVYFPAEAV NDFPVAMQVS EKYSIIYLVT KYGFIHLYDL ETGTCIFMNR
ISSETIFITA SDSASEGLVG VNRKGQVLSV AVDESTVIPY LLQNPANSGL AVKLASRAGL
PGADNLYAQQ FDQLISAGNY AEAAKIAANS PRGFLRTPQT IERFKNIPAQ PGQLSIILQY
FGSLLDKGDL NKHETLELVK PVLAQNRKHL IEKWMKENKL DCSEELGDLV RPHDLALALS
IYLRANIPQK VVAAFAELGQ FDKIVPYSSQ AGYQPDYIVL LQHIVRVNPE KGTEFATQLA
NNEGGSLVDV ERVVDIFQSQ NMVQAATAFL LDALKDNKPE QGHLQTRLLE MNLINAPQVA
DAILGNEMFS HYDKARIAQL CEQAGLSQRA LEHYEDPAAI KRVIVNIVAT PTFNQDWLTN
FFGRFSVEQS LDCLDAMMKS NIRQNLQAVV HIATKYSDLL GATKLIDLFE KYKTAEGLFY
YLGSIVNVSE DPDVNFKYIE AATKMQQFNE VERICRDSNH YNPEKVKNFL KEARLTEQLP
LIIVCDRFNF IHDLVLYLYQ NQHFKSIEVY VQRVNPARTP AVIGGLLDVD CDESIIKNLL
QTVNATSIPI DELVQEVETR NRLKILLPFL EATLASGNEQ QAVYNALAKI YIDSNNNPEK
FLKDNNQYDT LVVGKYCEKR DPNLAFIAYS KGQNDLELVN ITNENSMFKA QARYLLERAD
EELWNFVLSG NNQHRRSLVD QVISTAVPES KEPEKVSVAV SSFLKNDLPV ELIELLEKIV
LEPSPFSDNG SLQNLLIFTA TKADKSKVMD YIHQLNEYTT TEVADICIEV GLYEEAFEVY
KKIDDHPKAV NVLVEHIVSI DRAQEYGERV EIPEVWSRVA KAQLDGLRIS DAVESYIRAQ
DPNNYKEVIE YAVPAGKDED LIKYLKMSRK TLREPEIDTA LAFAYARTDQ LSELEDFLKG
TNVADIEESG DKAYAEGYHQ AAKIFFSSIS NWAKLATTLV HLSDYQAAVE CARKANNIKV
WKQVNAACVE KKEFRLAQIC GLNLIVDAEE LQDLVKQYER NGYFDELIAV LEQGLGLERA
HMGMFTELGI ALSKYHPERV MEHLKLFWSR INIPKMIRAC EEANLWPELV FLYCHYDEWD
NAALAMMERA ADAWEHHSFK DIVVKVANLE IYYRALNFYL QEQPSLLTDL LQALTPRIDV
NRVVKMFEKS DNIPLIKPFL LNVQTQNKKA VNNAINDLLI EEEDYKTLRD SVENYDNYDP
VELAQRLERH DLVFFRQIAS NIYRKNKRWE KSIALSKQDK LYKDAIETAA ISGKTEVVEE
LIRYFVDIGS KECYVGMLYS CYDLIPLHIV MELSWRHGLT DFTMPFMINF LAQQSATIET
LKKDNDERKA REQSQVKEEN NTPILGGSRL MLTQGPAGQP TSPAPYGQPN GFAPQPTGFG
GF
//
