ID A0A093XEC3_9PEZI Unreviewed; 1846 AA.
AC A0A093XEC3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KFX91050.1};
GN ORFNames=V490_06109 {ECO:0000313|EMBL:KFX91050.1};
OS Pseudogymnoascus sp. VKM F-3557.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1437433 {ECO:0000313|EMBL:KFX91050.1, ECO:0000313|Proteomes:UP000029320};
RN [1] {ECO:0000313|EMBL:KFX91050.1, ECO:0000313|Proteomes:UP000029320}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-3557 {ECO:0000313|EMBL:KFX91050.1,
RC ECO:0000313|Proteomes:UP000029320};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFX91050.1}.
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DR EMBL; JPJS01001787; KFX91050.1; -; Genomic_DNA.
DR STRING; 1437433.A0A093XEC3; -.
DR HOGENOM; CLU_237005_0_0_1; -.
DR Proteomes; UP000029320; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd11883; SH3_Sdc25; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR025332; DUF4238.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF14022; DUF4238; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000029320};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..57
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 733..866
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 902..1139
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 63..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 145..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1607..1628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1757..1787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 634..653
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..675
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1846 AA; 208634 MW; 9F1BDAA48A4E9D47 CRC64;
MYVRALYDYE ADDRTSLSFH EGDVIQVITQ LESGWWDGVI NGVRGWFPSN YCQVLSNPED
VLEDHRNHDD ADDDDLDGDD LYDEQYGALD DGEAERDHAA QQLPIEGFAT AGGDGGNKAR
ADFWIPQATP DGRLFYYNTM TGESSMELPL ESPSSATENG PRDRMNIAMP DKTRPPQEMM
AQGAFMEEEE YESEGNSASE LDGESIMMAS TGSLPRKRRS YGSEGISPAM SMESINGALP
SAQQRNDQFY TSNMFGTSST SVLPVAGAST TSFTSPTGGP VQAANVPRSF FDDGVAAPLT
WNRLVVNMKL AVNQYKDAIN NGQRSEYVRR AEDISDHLRL LLAAGSGTTD NHSGQPSIIS
TNKALYPHFR DMMSKFSKLV ISSHIAAADW PTPESYSKCL QEADGVLQGV FSYVEVARQQ
RGEDIPRLLP GFVIGSVAGG SWQNNGLGSR DPMTSNFLDE DEAALEPTAQ LDAKLLERMD
DLKRGLISSI RKLEEHLVVT EKIITPYRHE VIGNAICAAA GKVLEMFRPF VSTIESINLS
SLGTGFQNPQ LLDFSTYKQN LYDNISDLVL GCQAVAGPLG DEWAESRGES LEDRITYVRN
STRQLETNAS HIGFSLQLLG EQVQSSLQQE DLRPQSQRRV DGQGYDRVHQ RTESRQTPNP
PRGPTSAPQP PVADPIDPAS GNYRMGDNSK VKKFFGEEPA PPAALVRPRE VDETPDFLAL
DYEADLLYDT KIQPPALKGG TLLALVEQLT RHDKLDSSFN GTFLLTYRSF TTARELFEHL
VKRFQIQPPE GLAQADFDTW RDRKQKPIRF RVVNILKSWF DNFWMEDQSK ETMQLISDVY
TFARDTVKTT ETMGSGPLMV VLEQRLRGQD APAKRLVLTM NQSTPTPIMP KNMRKLKFLD
IDVTEFARQL TIIESKLYGR VKPTECLNKT WQKKIGEGDP EPAPNVKLLI LHSNQLTNWV
AEMILTQQDV KKRVVVVKHF VSVADKCRQL NNYSTLTSII SALGTAPIHR LKRTWDQIPA
RTITVLEQMR KLMGSTKNFG EYRETLHLAN PPCIPFFGVY LTDLTFIEDG IPSIIKKSAL
INFAKRAKTA EVIRDIQQYQ NVPYPLQPVP ELQDYILSNM QAAGDVHEMY ERSLQVEPRE
REDEKIVRVL AENVHRVDAA GGPGTTLLPR PIPRREIQLA CHMGGGAKGR LTTRVLWWSW
LFIARYIVRL LDDRETDYIY ANYTSRRHER PSTLLTRKTY KNPEEEHPEE YPEEYPEDII
HVFDLPSRQF YLGEVSTTCG APNLYENKND SKQMRIEELF SVLESKTGAI FSDIRTAIAN
GTDHIDIVER DVHTLFKFMN LSQRRSEQYR DEIKNPYRKN DFVIQRLLEA SRKNGQSDEP
GQFWLEQLLY LLEASHESLL ADAEKPNPNA SARTYKHFTE NYALQIWKAA EGYEFFLNER
LVDFEGDTQS CLGVELGESG GDQLILITSE DQIHFILPIS PDVAIVFCNE SRCWASPFAD
IIREFDKSYP ENSLLSRAPH KDICDIDVPA QKRSRKPAWP ATVAWRVNIG TLSREQHMII
ASFSLGHSKS FVVVKSRARF ERAKRELERF AKAKKEAWEA QGIRFMARDT QRQRQGENEQ
SPPSQERLAR MADEHMAALE KVVNIITTTN EPLPWTKDNM FTSWIAFRTI EYSNPKCPSP
SSLPISIMHP SLKPSFEAAY PPQHPDHRDL IEINFGEFFD YSLGEEMFAK LTAKIDSKVS
ELVNSDTLFT HSKPTAAAID SPSSSVPVVP VEEGLPSSDA PSRPEENDAM LKNPALISIF
RAAQCFEVLR WMFEERQDIL ATFVRQIVEP LEDLQPSVFR VRARRV
//
