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Database: UniProt
Entry: A0A093XKR6_9PEZI
LinkDB: A0A093XKR6_9PEZI
Original site: A0A093XKR6_9PEZI 
ID   A0A093XKR6_9PEZI        Unreviewed;      1231 AA.
AC   A0A093XKR6;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   25-OCT-2017, entry version 15.
DE   RecName: Full=Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific) {ECO:0000256|RuleBase:RU363018};
DE            EC=2.5.1.87 {ECO:0000256|RuleBase:RU363018};
GN   ORFNames=V490_06066 {ECO:0000313|EMBL:KFX91122.1};
OS   Pseudogymnoascus sp. VKM F-3557.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1437433 {ECO:0000313|EMBL:KFX91122.1, ECO:0000313|Proteomes:UP000029320};
RN   [1] {ECO:0000313|EMBL:KFX91122.1, ECO:0000313|Proteomes:UP000029320}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM F-3557 {ECO:0000313|EMBL:KFX91122.1,
RC   ECO:0000313|Proteomes:UP000029320};
RA   Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A.,
RA   Gerasimov E.S., Kochkina G.A., Ivanushkina N.E., Vasilenko O.V.,
RA   Kondrashov A.S., Ozerskaya S.M.;
RT   "Population genomics of a fungus Geomyces pannorum provides evidence
RT   of horizontal gene transfer but not of sexual reproduction.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adds multiple copies of isopentenyl pyrophosphate (IPP)
CC       to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl
CC       diphosphate (Dedol-PP), a precursor of dolichol which is utilized
CC       as a sugar carrier in protein glycosylation in the endoplasmic
CC       reticulum (ER). {ECO:0000256|RuleBase:RU363018}.
CC   -!- CATALYTIC ACTIVITY: (2E,6E)-farnesyl diphosphate + n isopentenyl
CC       diphosphate = n diphosphate + ditrans,polycis-polyprenyl
CC       diphosphate (n = 10-55). {ECO:0000256|RuleBase:RU363018}.
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC       {ECO:0000256|RuleBase:RU363018}.
CC   -!- SIMILARITY: Belongs to the UPP synthase family.
CC       {ECO:0000256|RuleBase:RU363018}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU363018}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KFX91122.1}.
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DR   EMBL; JPJS01001773; KFX91122.1; -; Genomic_DNA.
DR   EnsemblFungi; KFX91122; KFX91122; V490_06066.
DR   UniPathway; UPA00378; -.
DR   Proteomes; UP000029320; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR   CDD; cd00475; Cis_IPPS; 1.
DR   Gene3D; 3.40.1180.10; -; 1.
DR   HAMAP; MF_01139; ISPT; 1.
DR   InterPro; IPR001441; UPP_synth-like.
DR   InterPro; IPR018520; UPP_synth-like_CS.
DR   InterPro; IPR036424; UPP_synth-like_sf.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01255; Prenyltransf; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   SUPFAM; SSF64005; SSF64005; 2.
DR   TIGRFAMs; TIGR00055; uppS; 1.
DR   PROSITE; PS01066; UPP_SYNTHASE; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000029320};
KW   Membrane {ECO:0000256|RuleBase:RU363018};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029320};
KW   Transferase {ECO:0000256|RuleBase:RU363018};
KW   Transmembrane {ECO:0000256|RuleBase:RU363018};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU363018}.
FT   TRANSMEM    781    806       Helical. {ECO:0000256|RuleBase:RU363018}.
FT   TRANSMEM    826    845       Helical. {ECO:0000256|RuleBase:RU363018}.
FT   TRANSMEM    905    923       Helical. {ECO:0000256|RuleBase:RU363018}.
FT   TRANSMEM    935    958       Helical. {ECO:0000256|RuleBase:RU363018}.
FT   TRANSMEM   1014   1033       Helical. {ECO:0000256|RuleBase:RU363018}.
FT   TRANSMEM   1169   1193       Helical. {ECO:0000256|RuleBase:RU363018}.
FT   COILED      458    485       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1231 AA;  140275 MW;  082A567A451B1C90 CRC64;
     MTSMHLNQLR KWVYSSPPVE WGMNQLRELL IGAVSQGPVP QHIAFVMDGN RRFARSHKIE
     TAEGHNLGFE SLAKILEVCY KLGVKVITVY AFSIENFKRS KYEVDALMDL FKVKLAQISQ
     HGELLDQYGA SIRILGQRDL IRPDILEACN NAVEVTRGNG DAILNICFPY TSRDEITTAI
     RSTVDELSTP LPTPKRPFSE RRIAQKLRSR NLTSTSSPPR EASPSRVEVP GAELDDSISS
     SATLHPDSVE NSDVPNPDEP SYPDPESITA ATVESHLFTA GNPPLDLLIR TSGVNRLSDF
     MMWQCHEDTQ LRFLDCYWPE FSLRHFLPVL IEWQWQRKYG DDKEGGAVKA RPKFFAIMAP
     AKDTMFRSVD MSMVQLYVAN EIGREVINAL GEIGQIQFRD LNSETSAFQR TFTQEIRRLD
     NVERQLRYFH SQMEKAGIPL RKLDLDIESL AAPSTSEIDE LSDRSQSLEQ RVSSLNDSYE
     TLKKREVELI EWRWVLKEAG GFFDRAHGNV DELRTSIDQD DDAPLLQDVE QHPQNGDAGE
     RSLSIMNIGF VSGVIPRERV AAFERILWRT LRGNLYMNQS EIPETLVDPT NNESVDKNVF
     VIFAHGKEII AKIRKISESL GADLYAVDEN SDLRRDQIHE VNTRLSDLGS VLRNTKQTLD
     AELTQIARSL AAWIVIIKKE KAVYETLNLL SYDHARKTLI AEAWCPSNSL PQIKAALQDV
     NNRAGLTVPS IINEIRTNKT PPTLQKTNRF TEGFQTIINA YGTSKYHEVN PGLPTIVTFP
     FLFAVMFGDL GHGFIMFCAA AAMIYWEKPL KKVRDELFTM AYYGRYIMLM MGIFSMYTGM
     IYNDIFSRSM SIFSSAWEWP EHFEKGDVVL ASLKRSGHRY PFGLDWMWHG AENELLFANS
     YKMKLSILMG WCHMTYSLCL SYVNARRFKS PIDIWGNFVP GMIFFQSIFG YLVFTIVYKW
     STDWYPMAPD DWPVGVQPPN HRNPPGLLNM LIYMFLQPGT VVEPLYGDGT LQKIIQNFLV
     IIALIQVPIL LFLKPFYLRW ENNQARAKGY RGIGETSRIS ALDGDDDDRR SFSRASIASE
     TEGVDMITQG IDNDSEGHEE FEFGEVMIHQ VIHTIEFCLN CVSHTASYLR LWALSLAHQQ
     LSLVLWSMTI NIGLNSTGIS GVFTLVVTFY MWFFLSVCVL VVMEGTSAML HSLRLHWVEA
     MSKHFMGDGI AFEPFSFRQM LEEDEEVKEF S
//
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