ID A0A093XUQ8_9PEZI Unreviewed; 1208 AA.
AC A0A093XUQ8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN ORFNames=O988_08184 {ECO:0000313|EMBL:KFX90489.1};
OS Pseudogymnoascus sp. VKM F-3808.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1391699 {ECO:0000313|EMBL:KFX90489.1, ECO:0000313|Proteomes:UP000029329};
RN [1] {ECO:0000313|EMBL:KFX90489.1, ECO:0000313|Proteomes:UP000029329}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-3808 {ECO:0000313|EMBL:KFX90489.1,
RC ECO:0000313|Proteomes:UP000029329};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFX90489.1}.
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DR EMBL; JPJR01002047; KFX90489.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093XUQ8; -.
DR STRING; 1391699.A0A093XUQ8; -.
DR HOGENOM; CLU_002472_1_0_1; -.
DR Proteomes; UP000029329; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000029329}.
FT DOMAIN 1044..1060
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 88..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..182
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..274
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1208 AA; 133987 MW; 2C5DA216CC50DD17 CRC64;
MAKTEKSTTT PSRPAPAKKQ GSSAATSTGK NQRSILGFFS KTPAAGLPLL KKQSSPPPAL
ESAQTDGASA KIPVGKAVEK VGRAVKMMNR TPVASSDAIE PPSSQGEGDN NGVAQSSPSR
RAKKPLSYAE SDDEDEDDEG PTTARRNKSR KKVIESDDEE DVFVGEADDA SDDDDDMDGF
IASEDSDVAP SKSKKRKRPS PSKTPSRKRS YAPSPLPPIE DDVEMGDSQG SSAQRWKYDP
DDTKPLQPRS SNIVRKPKTT LGEPAKKQKA SKTEPEHRYT WLANLLDMDR NPPDHPDYDP
RTVYIPPNAW TGFSAFEKQY WQIKQKFWNT IVFFKKGKFY ELYENDATIG HQLFDLKLTD
RVNMRMVGVP ESSLDHWANQ FVAKGYKIAR VDQMESALGK EMREREDSVG GAKAKKVDKI
IHRELACVLT KGTLVEGSML EDDMATYCVA IKETTSTADD LPTFGIAFVD TATGQFFLSE
FVDDVDLTKF ETFVAQTRPQ ELLLEKSCIS VKALRILKNN TSPTTIWNYL KTGKEFWGAD
ATKRELDCSG YFLNDEPGAD EEWPATLTEA REKEIIMSAF GALVQYLRSL KLDRDLLSQR
NFAWYNPIQK STTLVLDGQT LINLEIFANT YDGGQAGTLF KMLNRCITPF GKRMFRQWVC
HPLADARKIN ERLDAVDMLN ADSTLREQFT AEMTRMPDLE RLISRIHAGV CRPDDFVRVL
EGFEQIEYTM SMLGAFRGGD GIIDRLISGM PDLVGPLEYW KTAFDRTKAR DERLLVPERG
IEEDFDESED RILGIKQELT GLRKEWAAKL GAKAVQFKDV GKEIYQLEVP VKNSKAVPKD
WTMVSSTKAE KRYYFPELKT LVRALQEAQE THGQIVKATA GRFFQRFDKD YSTWLTAVNI
IAQLDCLISL ARASATLGSP SCRPTFVDTD RTVVDFTELR HPCVLPNVTD FIPNSIRLGG
ASPNINLLTG ANAAGKSTIL RMTCIAAIMA QIGCHVPAES ATLTPIDRIM SRLGANDNIF
AAQSTFFVEL SETKKILAEA TPRSLVILDE LGRGTSSYDG VAVAQAVLHH VATHVGAIGF
FATHYHSLAA EFAGHPEIAP RRMAIDVDEA ERRVTFLYRL EEGVAQGSFG MHCASMCGIP
RKVVERAEVA AKEWEHTSRL TAGLEVAKRG AYVPLGWQSD IAWMLKKGAL GEGADRGVEV
LIKAIAGI
//
