ID   A0A093XVX9_9PEZI        Unreviewed;       578 AA.
AC   A0A093XVX9;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Pseudouridine synthase I TruA alpha/beta domain-containing protein {ECO:0000259|Pfam:PF01416};
GN   ORFNames=O988_05168 {ECO:0000313|EMBL:KFX96798.1};
OS   Pseudogymnoascus sp. VKM F-3808.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1391699 {ECO:0000313|EMBL:KFX96798.1, ECO:0000313|Proteomes:UP000029329};
RN   [1] {ECO:0000313|EMBL:KFX96798.1, ECO:0000313|Proteomes:UP000029329}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM F-3808 {ECO:0000313|EMBL:KFX96798.1,
RC   ECO:0000313|Proteomes:UP000029329};
RA   Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA   Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA   Ozerskaya S.M.;
RT   "Population genomics of a fungus Geomyces pannorum provides evidence of
RT   horizontal gene transfer but not of sexual reproduction.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase TruA family.
CC       {ECO:0000256|ARBA:ARBA00009375}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFX96798.1}.
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DR   EMBL; JPJR01001004; KFX96798.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A093XVX9; -.
DR   STRING; 1391699.A0A093XVX9; -.
DR   HOGENOM; CLU_014673_2_3_1; -.
DR   Proteomes; UP000029329; Unassembled WGS sequence.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd02569; PseudoU_synth_ScPus3; 1.
DR   Gene3D; 3.30.70.660; Pseudouridine synthase I, catalytic domain, C-terminal subdomain; 1.
DR   Gene3D; 3.30.70.580; Pseudouridine synthase I, catalytic domain, N-terminal subdomain; 1.
DR   HAMAP; MF_00171; TruA; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR001406; PsdUridine_synth_TruA.
DR   InterPro; IPR020097; PsdUridine_synth_TruA_a/b_dom.
DR   InterPro; IPR020095; PsdUridine_synth_TruA_C.
DR   InterPro; IPR041707; Pus3-like.
DR   InterPro; IPR020094; TruA/RsuA/RluB/E/F_N.
DR   PANTHER; PTHR11142; PSEUDOURIDYLATE SYNTHASE; 1.
DR   PANTHER; PTHR11142:SF5; TRNA PSEUDOURIDINE(38_39) SYNTHASE; 1.
DR   Pfam; PF01416; PseudoU_synth_1; 1.
DR   SUPFAM; SSF55120; Pseudouridine synthase; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029329};
KW   tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT   DOMAIN          298..433
FT                   /note="Pseudouridine synthase I TruA alpha/beta"
FT                   /evidence="ECO:0000259|Pfam:PF01416"
FT   REGION          150..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          558..578
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        153..172
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   578 AA;  65556 MW;  F8267A73365C41E1 CRC64;
     MATPPVEKIN YKEWSHENLI KRVTELEHNL KLKNAHYPVA TPQKSYKKVR TEKHFDPSRY
     STRLIALKLA YLGKAYNGFE HHVGNKTPLP TVEEKLWEVL VKARLIFPKG ASPDGKGEIN
     WDGCDYSKCG RTDKGVSAFG QVIGLRVRSN RPLPKHTAAE PRDGTEDFNH TMPRDNALEM
     ASPALRPSIQ EGRSANPPEL SIDDPEFEEA FDFDPIADEL PYCHLLNRLL PPDIRILAWC
     PAPPLGFSAR FSCKERQYKY FFTQPAFAPP PENPSIERTN KYTNVKDGWL DIDAMREAAS
     YFVGSHDFRN FCKIDGSKQI TNFERTMFFA DILEVDDTTP VLDFVGKKEF TPAPSIIGSS
     EQVSPKVYTF TLHGSAFLWH QVRCMVSILF LVGQGLEKPT IIKELLDVEK NPSRPAYEMA
     QDAPLVLWDC VFPHEDDPSR ENAIQWLHVG DEPGRGDTKW GTVGLIEDLW KVWRERKIDE
     VLASNLLSAV AKQGGAIEGL TSDHWAKVVR SQKVYDGNNK PKLTGQYTPV MKKPLMERPE
     VINEKYAVRK GFEGSADLKT QGFRRMNKPS EPNDNADE
//