ID   A0A093YPI9_9PEZI        Unreviewed;       941 AA.
AC   A0A093YPI9;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN   ORFNames=V492_07661 {ECO:0000313|EMBL:KFY06886.1};
OS   Pseudogymnoascus sp. VKM F-4246.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1420902 {ECO:0000313|EMBL:KFY06886.1, ECO:0000313|Proteomes:UP000029299};
RN   [1] {ECO:0000313|EMBL:KFY06886.1, ECO:0000313|Proteomes:UP000029299}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM F-4246 {ECO:0000313|EMBL:KFY06886.1,
RC   ECO:0000313|Proteomes:UP000029299};
RA   Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA   Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA   Ozerskaya S.M.;
RT   "Population genomics of a fungus Geomyces pannorum provides evidence of
RT   horizontal gene transfer but not of sexual reproduction.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFY06886.1}.
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DR   EMBL; JPJU01002683; KFY06886.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A093YPI9; -.
DR   STRING; 1420902.A0A093YPI9; -.
DR   HOGENOM; CLU_010210_0_0_1; -.
DR   Proteomes; UP000029299; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR   PANTHER; PTHR12673:SF267; GUANYL NUCLEOTIDE EXCHANGE FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13320)-RELATED; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000029299}.
FT   DOMAIN          248..491
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          54..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          199..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          787..841
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          908..941
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        818..841
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        919..941
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   941 AA;  103907 MW;  F1C77E43AA06F644 CRC64;
     MAGHGIQQEG NFNVPLVCPR QSNPINTLKV EDKLQSSPHG PSNQVKGTLD AANGVNELHT
     TPPSRNDTPD DTEGWDTVDN ITALGLAFGY SNTPEKASPT KNRFVLDDLE PRHEPPNIQP
     TRPPFEKWVK RFNRKAIQRH RRSHSIAGTG VSDSDIHSLE ARNRNGYHLR KSASGSSLGF
     VTAVKSASIS LASFSIAAKS RNRGHSSKHQ RTDRSSRASN IGPRTSEDSV SAARGRANDV
     AVTNRSIRRR RVLEEIISTE EGYFGDVKFL MNVYVTLLAS VPTLPSLRAS ISRNLSEIVE
     LHDELLGDLH RVVPHSEYTQ PDYVATPELA KQGHHCWRSL DAVPEHSEDL SWAQKIPGMI
     AEAHVAADVA KVFGKRMHRF FAYEEYGAKY EVMVKNMATA YKTLPQWEEY QKGLEALAAS
     LESTNIHNGQ PNKSLTLGDL LVKPIQRVCR YPLLFAELLR QTPVYDCPES HMEIEKVLVR
     LREMTSETNK ATDDPLMKAT MEKTWLLQDR LLIPDQVDPQ SKSLIRSLGH VHLCGVLHVA
     WQTKNGVDGQ HMIALLYRDC LVLASVEKLE SVYNVGAIIF FSDIRIEEPD NGKGIQCHTA
     PFSWKIVFEC DHQLFEIIFS ACSSKEELEW RNRLNICTSR EHIDSYDQAF MTTMSLGIKS
     LGTVFGKPGT VARKLSIRRA TTVGPKSPLC QVIIKNTSAT KDTASSSTNT VVNRSQSLLG
     TNRIPVLAPS RAERVRLERL LSDVWTKQII PYPGMTGRAR SEHIVRSSAS SMMRKLSVAS
     ITSNFTKRSG NAVSPRVPSG PTREDNSDGK FAISDSGPGS PVRNNAVESA PGNAQPTTSI
     NGVDLHFDSI FDEKMTNLTA PPVIDTSPIG TMKRLAALRV KNVLQTDKNR RLASPPTTPR
     KVSLSQMMMR AASGGSIGGH SGSPLSEISR ESENQTPVKA V
//