ID A0A093Z411_9PEZI Unreviewed; 611 AA.
AC A0A093Z411;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=V492_08285 {ECO:0000313|EMBL:KFY05815.1};
OS Pseudogymnoascus sp. VKM F-4246.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420902 {ECO:0000313|EMBL:KFY05815.1, ECO:0000313|Proteomes:UP000029299};
RN [1] {ECO:0000313|EMBL:KFY05815.1, ECO:0000313|Proteomes:UP000029299}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4246 {ECO:0000313|EMBL:KFY05815.1,
RC ECO:0000313|Proteomes:UP000029299};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY05815.1}.
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DR EMBL; JPJU01003561; KFY05815.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093Z411; -.
DR STRING; 1420902.A0A093Z411; -.
DR HOGENOM; CLU_005431_2_0_1; -.
DR Proteomes; UP000029299; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF348; GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000029299}.
FT DOMAIN 108..234
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 349..583
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 242..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..298
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 611 AA; 68590 MW; 384D5711A269CD55 CRC64;
MPRAIPPPQM SSRTIPTRQK VDTDTIQVFQ EKADVPTTGQ RRLSQGQFAS NTATATPQTD
DENDTPERKR SGGVPSSLDV EESEIDSSPR YSDDIPILQR SDEVVPDKHV KVSGFTFDEL
VDRLLSQPMS KADSNFTDIF LCMYRKFASP GTLLSAILSR LEKSADEKGQ HFLTRTTVQL
RIIAVLTKWI SQYPGDFAAP TTNQRISAFV DQISNEPAFN YAVQEMRTML RFHVVEDDDT
RWANSDIEDP DSEETNELVP VTSSTHSSRS TEASKNASHT SLSDEKNSRR DRRHSETVSV
TSSDVAAAPG GQPSAFHTVR DYEIEAATFV PSKKHLLTKL LFHNCMEISD DDFAEEITRI
DWIMFSSVRV RDLVRDVSLS AKQKAKCKSL VNVTRAINHF NHVAWWVTNL ILLRDKAKHR
AQILEKFMRI AWKLRQMNNY NGLAAVMAGI QNTGVGRLAQ TQALITDDCR KQFMRLEILM
GRQRSHFAYR LAWQNSTLPR IPYVPLSRRD LASADEGSKT FVGPKGDRIN WSKFEVFGGV
ILPIMKSHST PVNLEKHDNA REIILDCFIS ADEDVSNSRI GPTFSTAAND GIGNIPTKLV
TGGFHLKQGS K
//
