ID A0A093Z9N1_9PEZI Unreviewed; 792 AA.
AC A0A093Z9N1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Peptidase M28 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=V492_02902 {ECO:0000313|EMBL:KFY14036.1};
OS Pseudogymnoascus sp. VKM F-4246.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420902 {ECO:0000313|EMBL:KFY14036.1, ECO:0000313|Proteomes:UP000029299};
RN [1] {ECO:0000313|EMBL:KFY14036.1, ECO:0000313|Proteomes:UP000029299}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4246 {ECO:0000313|EMBL:KFY14036.1,
RC ECO:0000313|Proteomes:UP000029299};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY14036.1}.
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DR EMBL; JPJU01000883; KFY14036.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093Z9N1; -.
DR STRING; 1420902.A0A093Z9N1; -.
DR HOGENOM; CLU_005688_2_0_1; -.
DR Proteomes; UP000029299; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08022; M28_PSMA_like; 1.
DR CDD; cd02121; PA_GCPII_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404:SF46; GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG; 1.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000029299};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 35..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 198..273
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 391..578
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 666..790
FT /note="Transferrin receptor-like dimerisation"
FT /evidence="ECO:0000259|Pfam:PF04253"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 792 AA; 87486 MW; ECE152212984686B CRC64;
MAPDDRTPLL GASSTAQPAR AAQQQRSPAA VRRRFAYIAT GSLAIAFVVF VLIPAAFIPR
ILDDLVPSRG KFQYAELEDI LLNSPSTEKL SEWSKYYTSG PHLAGTNLSQ AVWTQEKWKE
FGIEDSSVVP YEVYLNYPLG HRLALLEKPS KGHANEDEAS WKVKFEASLE EDILEEDPTT
GSPDRIPTFH GYSANGNVTA QYVYVNYGTY HDFEDLIKAN VTLKGNIAIA RYGHVFRGLK
IKRAQELGMV GAVLYTDPGD DGAPLHDMAE AYPDGPGRNP SSVQRGSAQF LSMGPGDPTT
IGYPSKPGVP RSPTDDNIPQ IPSIPISYID ALPILKALNG HGPTPKELNK YWDVNLGLEP
RGVHYNAGPS PEGLVLKLVN EQDYKITPIW NVIGIINGTL SDEVIVVGNH RDAWIVGGAG
DPNSGSAAMM EVIRGFGQAL SKGWKPLRTI VFASWDGEEY GLVGSTEWVE EYVPWLSEAN
VAYVNIDVGC SGPEFVAAAS PLLNSLLYEV TGKVQSPNQT VEGQTVRDVW GGHIKTMGSG
SDFTAFQDYA GISSIDIGFT ASHQSAIYQY HSNYDSYHWM ETYGDPGWHY HAAITKVLGL
FVAKLVHAPL VPFRTTDYGK ALISYVQQID DLLESGPARS STLRFHPTPD ASTDSTARRK
YIRRRLEEMQ GSAHHFLKVA RVFDEHVDTL QERAEHGYGW LRWCARLKLY LGVRKANFAM
KLLDRKFLHA PGLTGRSWFK HVIFAPGLWT GYAGAVFPSL AEAIDDEDEM GAIKWIRIID
DRIIQATRSL EL
//
