ID A0A094AXQ3_9PEZI Unreviewed; 1204 AA.
AC A0A094AXQ3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Linoleate 8R-lipoxygenase {ECO:0008006|Google:ProtNLM};
GN ORFNames=V493_03251 {ECO:0000313|EMBL:KFY27870.1};
OS Pseudogymnoascus sp. VKM F-4281 (FW-2241).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420906 {ECO:0000313|EMBL:KFY27870.1, ECO:0000313|Proteomes:UP000029327};
RN [1] {ECO:0000313|EMBL:KFY27870.1, ECO:0000313|Proteomes:UP000029327}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4281 (FW-2241) {ECO:0000313|Proteomes:UP000029327};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY27870.1}.
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DR EMBL; JPJV01001242; KFY27870.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094AXQ3; -.
DR STRING; 1420906.A0A094AXQ3; -.
DR HOGENOM; CLU_002329_1_0_1; -.
DR OrthoDB; 3322316at2759; -.
DR Proteomes; UP000029327; Unassembled WGS sequence.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProt.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR CDD; cd20612; CYP_LDS-like_C; 1.
DR CDD; cd09817; linoleate_diol_synthase_like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR036396; Cyt_P450_sf.
DR InterPro; IPR019791; Haem_peroxidase_animal.
DR InterPro; IPR010255; Haem_peroxidase_sf.
DR InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR InterPro; IPR034812; Ppo-like_N.
DR PANTHER; PTHR11903:SF37; LINOLEATE 8R-LIPOXYGENASE-RELATED; 1.
DR PANTHER; PTHR11903; PROSTAGLANDIN G/H SYNTHASE; 1.
DR Pfam; PF03098; An_peroxidase; 2.
DR Pfam; PF00067; p450; 1.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR PROSITE; PS50292; PEROXIDASE_3; 1.
PE 4: Predicted;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00022964};
KW Reference proteome {ECO:0000313|Proteomes:UP000029327}.
FT REGION 75..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..106
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 508
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ SEQUENCE 1204 AA; 133563 MW; 59210B81E98178DC CRC64;
MGITLYLADA ADSAHAAHLA KRSALLGYYQ YFTPPLYCSS TLSQAPVSPS HKPWFVCICF
RVRICIASAL PMQPPYPTRH PVTPSPADLE SSPPNALPPM DPPPSPNQRG LRGASSVSAT
SISSLPRPRH LSFSFLNPTL RMAPSQFKTL LGSMRRKPSH APDGKTDEQA YGKSMEEKTS
IVHDLTHLNL THTRTVAEAI TTLASGEPMD DKDLLLEKGV SMLQTLPANS GLSQTISNKF
IGMLWNDLPH PPPTTAGPSA RYRQPDGSGN NPWVPEMGKA GAPYSRSVPP TKPKGPNLPD
PELVFDQLLK REGPFREHPS GLNRLFFSFA TVVIHECFQT SRTNPLINET SSYVDLSTIY
GNNAEEQKRV RTNEQGRIFP DSLASERIML MPPGVVAVLL MFSRNHNHIV ENLLSVNEGG
KYKDWDSLNK TEQAWQDEDL FQLTRNINVG FFASVVLKDY VAAILNTPRA NSTWSLDLGA
EIKNGPERLE RGSGNVVSVE FAVLYHWHAA LSAADDQWME DVLRSHLPEL QSIDDVTAAD
FKKVMMTEGH KLMATPPKEW TFGGLKRGAD GKFNDVDLAE IIKDCIEEPA HAFGAHSTPA
SLKIVDIMGQ MQARDMFNVC TMNEFRRYLN LKPYEDFEDW NPDKETARAA ELLYGHIDNL
ELYPGLMAEV TKPAMPGSGV CPGHTTGRGI LDDAVALVRG DRFLSYDFNS TTLTNWGFAK
LGTVPAGAYG GMLPHLLFNA LPGAWTGTST YALLPFYTPI AAKGILKGNK VLDQYDLERP
ASDKVVLGIH THEGCKKVFE DRENFRVMYQ AAIRKCTDGH DFMIGWDDAH RHDARSSILH
KVFFEEGFEA NLTKFFRTNV SRLIKEKSLK YSSNRRAIDI VRDVTNVTPI LWLAERFAIP
LKTKEQPRGL MSTPELFTIY LVLFMYQSFN IIPANEWKLR EGAMKAAPAL RAVFEAHLKT
QQGFKEGIVD WLAKGSAFEV GPDADRLYHA LNESKLPIGD LVGDCIGMGA PVAGNLTQQA
SLLIDLFLSE GYEEYKDRII ELSHKDDAAS ERELQGFVFE GMRHAGVVPG LPRVASKDVT
IMDGSRGPIS IKAGHTILIA TSKAAMDPIQ FPNPEKLNPH RPFKDYILLG HGLHFCFGAR
LVGCSLAATL KEVFKLKNIR RANGRQGHFS IVEHEFAGVK MRQYLDGNAN ESPIPTTLTL
EYDE
//
