ID   A0A094B775_9PEZI        Unreviewed;      1049 AA.
AC   A0A094B775;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=Enoyl reductase (ER) domain-containing protein {ECO:0000259|SMART:SM00829};
DE   Flags: Fragment;
GN   ORFNames=V494_05885 {ECO:0000313|EMBL:KFY35468.1};
OS   Pseudogymnoascus sp. VKM F-4513 (FW-928).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1420907 {ECO:0000313|EMBL:KFY35468.1, ECO:0000313|Proteomes:UP000029288};
RN   [1] {ECO:0000313|EMBL:KFY35468.1, ECO:0000313|Proteomes:UP000029288}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM F-4513 (FW-928) {ECO:0000313|Proteomes:UP000029288};
RA   Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA   Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA   Ozerskaya S.M.;
RT   "Population genomics of a fungus Geomyces pannorum provides evidence of
RT   horizontal gene transfer but not of sexual reproduction.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFY35468.1}.
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DR   EMBL; JPJW01001985; KFY35468.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A094B775; -.
DR   STRING; 1420907.A0A094B775; -.
DR   HOGENOM; CLU_000022_38_3_1; -.
DR   OrthoDB; 5396558at2759; -.
DR   Proteomes; UP000029288; Unassembled WGS sequence.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   CDD; cd05195; enoyl_red; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR013217; Methyltransf_12.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR43775:SF29; ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED; 1.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF13602; ADH_zinc_N_2; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF08242; Methyltransf_12; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 3.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000029288};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT   DOMAIN          407..729
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFY35468.1"
SQ   SEQUENCE   1049 AA;  111993 MW;  C0F1AA474E231C20 CRC64;
     YPDLEYLELG AGRGETTRHA LDALDGCAKY RYPKVKAYTY SDPCDATFRD AAKRWEKWGS
     LFETRVLDIA GDIGAQGFGG RSFDVIIAAN TLCDIAEDAV DLALANVRTL LKPGGKLILL
     EATHLHLSAS LILTRPAQPW QEHQWEDALS RHGFGGLEAS APDVLDARAH VTSVMVASVL
     KPQSIVAGLP LPLSLHVVLV APSGGGSAAA ELLDSTCSAL GGHGIGVEIV TFSGLARTEL
     QGKIVICLAE LDVSVLADVM PADFAQLQRL TREPVGLLWI TRGSIAGRST KPELSIFPGL
     ARSLRAEQEG FPCVTVDLDA DYRLPADQVV DLLFGVFRQT FVRGQAAGVN DREFAERNGI
     LHVKRMVEDD AFNKYIATRT GAASLKPRAE KLAQRDRPLK LAIDGVGSLD SFYFSDDTSV
     GRTVPMAKGE VEISVQAVGL NFRDILIAMG EMSDNYLGNE CAGVVTQVGE GVSHVRVGDR
     VAVWCLGCFA TLMRNPADTV MKIPEDMDFV TAAGFPIIYV TAYYSLVHLA RLQAGESVLI
     HAAAGGVGQA AIQIAQRLGA EVYVTVGTGE KKAHIMELFG IPSERIFSSR DVSFEAGIKR
     VTDGRGVDVV LNSLAGESLR ASWRCVAPFG RFVELGKRDI EAGGRLDMSV FARNVVFASV
     DITAMLRLNR RLGASVFREA MAMGMEIRHE LLGMGVEGGA SPVRTFGFGE VAEAFRHMQA
     GRHVGKIVVV PRQGDVVQVM PKPLKGAKFH ADASYLLAGG LGGIGRSLSM WMAANGARNL
     IFVSRSGVSN DAARELVGTL LAKGVRVEVI KCDIADEVKL FDSLNSVLRT MPPIRGVIQG
     AMVLRDQIFA NMPYETFVSA LRPKVQGSWS LHQATLDQPL DFFVLLSSAS SFLGNAGQGN
     YVAACTYQVA LAAHRLSLGL PATAVDIGKV ASVGVVAESA NSAMEANLVR IGLRDIQEAE
     LHAIIELAML PNAVGVTNGH LITGAHTSLD PGADAADLPF WSRDPVFSHL DALRPHLAQR
     AVEIRSHCRG PGCAVGEARA RAGDAGGGD
//