ID A0A094BFH8_9PEZI Unreviewed; 1073 AA.
AC A0A094BFH8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=DNA mismatch repair proteins mutS family domain-containing protein {ECO:0000259|PROSITE:PS00486};
DE Flags: Fragment;
GN ORFNames=V492_05603 {ECO:0000313|EMBL:KFY09117.1};
OS Pseudogymnoascus sp. VKM F-4246.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420902 {ECO:0000313|EMBL:KFY09117.1, ECO:0000313|Proteomes:UP000029299};
RN [1] {ECO:0000313|EMBL:KFY09117.1, ECO:0000313|Proteomes:UP000029299}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4246 {ECO:0000313|EMBL:KFY09117.1,
RC ECO:0000313|Proteomes:UP000029299};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY09117.1}.
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DR EMBL; JPJU01001982; KFY09117.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094BFH8; -.
DR STRING; 1420902.A0A094BFH8; -.
DR HOGENOM; CLU_002472_1_0_1; -.
DR Proteomes; UP000029299; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756};
KW Reference proteome {ECO:0000313|Proteomes:UP000029299}.
FT DOMAIN 1043..1059
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..183
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..273
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1073
FT /evidence="ECO:0000313|EMBL:KFY09117.1"
SQ SEQUENCE 1073 AA; 119464 MW; E1CB802F23E009BE CRC64;
MAKSEKSTTT PSRPAPARKQ GGSAAPSTGK NQRSILGFFS KTPTAALPLL KKSSPPATLE
EAQTDGAAAR TPAAEKAPGK VGRAVKKMDR TPVASSDVIE PPSSQGEGEK GAVLQSSPSR
RAKKPLSYAE PDEDEEEDEG PKTARRGKAR KRVVESDDDE EDVFVGEAEE ESDDDDMDDF
IASEDSDAAP SKTKKRKRPS PSKTPSRKRS APSPLPPVED DVEMGDSQGS SAQRWKYDPE
DTKPLQPRSS NIIRKPKPAS GEPAKKQKAH KTEPEHRYTW LANLLDMDRN PPDHPDYDPR
TVYIPPNAWT GFSAFEKQYW QIKQKFWNTI VFFKKGKFYE LYENDATIGH QLFDLKLTDR
VNMRMVGVPE SSLDHWANQF VAKGYKIARV DQMESALGKE MREREDSVGG AKAKKVDKII
HRELACVLTK GTLVEGSMLE DDMATYCVAI KETTTTADDL PTFGIAFVDT ATGQFFLSEF
VDDVDLTKFE TFVAQTRPQE LLLEKSCISV KALRILKNNT SPTTIWNYLK TGKEFWGADV
TKRELDCSGY FLTEEPGADE EWPATLTEAK DKEIIMSAFG ALVQYLRSLK LDRDLLSQRN
FAWYNPIQKS TTLVLDGQTL INLEIFANTY DGGQAGTLFK MLNRCITPFG KRMFRQWVCH
PLADARKINE RLDAVDMLNA DSTLREQFTA QMIRMPDLER LISRIHAGVC RPDDFVRVLE
GFEQIEYTMS MLGAFRGGDG IIDRLISGMP DLVGPLEYWK TAFDRTKARD ERLLVPERGI
EEDFDDSEDR ILGIKQELSG LRKEWAAKLG AKGVQFKDVG KEIYQLEVPV KNTKAVPKDW
TMVSSTKGEK RYYFPELKTL VRALQEAQET HGQIVKATAG RFFQRFDKDY ATWLTAVNII
AQLDCLISLA LASATLGTPS CRPTFVDTER TVVDFTELRH PCVLPNVTDF IPNSIRLGGA
EPNINLLTGA NAAGKSTILR MTCIAAIMAQ IGCHVPAESA TLTPIDRIMS RLGANDNIFA
AQSTFFVELS ETKKILAEAT PRSLVILDEL GRGTSSYDGV AVAQAVLHHV ATH
//
