ID A0A094BL94_9PEZI Unreviewed; 3506 AA.
AC A0A094BL94;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Carrier domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=V494_02410 {ECO:0000313|EMBL:KFY42429.1};
OS Pseudogymnoascus sp. VKM F-4513 (FW-928).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420907 {ECO:0000313|EMBL:KFY42429.1, ECO:0000313|Proteomes:UP000029288};
RN [1] {ECO:0000313|EMBL:KFY42429.1, ECO:0000313|Proteomes:UP000029288}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4513 (FW-928) {ECO:0000313|Proteomes:UP000029288};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY42429.1}.
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DR EMBL; JPJW01000842; KFY42429.1; -; Genomic_DNA.
DR STRING; 1420907.A0A094BL94; -.
DR HOGENOM; CLU_000022_31_2_1; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000029288; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF22; SYNTHASE, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00440; ACYLTRANSF_C_2; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000029288};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 8..433
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2446..2523
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3207..3506
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 2527..2557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 2854
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 3506 AA; 386055 MW; 76C47573C686760E CRC64;
MDSNPQQPVP IAIIGMGCRY PAGSNSPEDL WNVVAEGQSG WTEVPLDRFN HQAFYHPDPE
IPGVINQKGG HFIDQNIAAF DAGFFGIAQL EAETLDPQQR VVLETSWEAV ENAGIPMHHF
RGSDTGIFVA MFGHDFEQII HKDPASLSKY HNLGVARPLL ANRVSYVFDL QGPSVMLDTA
CSGSLVAVSS ACQSLRSGET YMALAGGVGL IFSPDQMALM SMTGLFNDQG RSYTFDDRGN
GYGRGEGVGM VALKRLDDAL RDGDNIRAVI RSSGMNSDGR TNGIMLPSQT AQERLARSLF
RNLPFTPADV QYAEAHGTGT KAGDEVEMTT IRNVFGKGRD SQNPIFLGAI KPNIGHSEAA
SGTAGLIKTV MAMEKGLIPP NILLENFKPG LEPDDCVKVA RSLTPWPSTT STRKAVVNSF
GFGGTNAMVV LESGKIYSGV NGSVNGHLNG EVNGLHYDGV KKDKKAIRLF TISARSEYSL
QHAANDLRAY LERQGPVQVQ LDDLSYTLTA RRSKFQWRSS IVAHDVNSLV QGLSAENLAR
NKAPNKVENV FIFTGQGAQS ARMGYHLLSS EGNEFSRSIS RSEQLLKDLG AQWSLVEELS
RDESSSRLDE SKYGQPASTA VQLALVDLLK SWNVQPVAVI GHSSGEIAAA YAAGAISQSA
AMGASYHRSF LSEIAKQRTT HAGAMMAVGL GQSDAKKYIE KLDTCGVTVA CINSPSSTTI
SGDAAAISDL KSLLDADGVF ARQLNVDTAY HSHYMKLVSP DYLERLEGLD AGSVDPSIRY
FSSVTGKEKL DGFGASYWVD NLVSPVLFSA ALLSLCQEFS HTSLNLIEIG PHKALSGPIR
QTLASLQADR LSYTYIPTLT RGENSVESLL NTGSILFGSG SDLDIGAVAS LGILSSLPPV
ILRDLPTYHW NHTTTFWTES RLSREHRQRK HSPHDLLGSR VVTSPDNQPS WRILLSTERL
PWLKDHVVDN FIVFPAAGYM TMAVQAMRQL DEDRRPDLKP KGYRMKNVSF KKTLTLPKDY
NSVETIITFQ SSDSNKFSTF TVSSISDQGK WQEHCDGSIS TVFGPDLDEI EQGREAEFGR
KSQAARLENA RESCTKVISH EDLYSQMAAM GNQYGPSFAI NNEARISNFQ SLNGLVIPDI
AASMPGKFIE THVIHPTTLD AIIQACVPVF QQHSIRGAVM PILIGDMFIS TDIVNQPGKQ
LETVCDLRDT FAHSTNMDTA AFQTDKGGEP ICVLTMDNVE IRVVGESQTS LQKPENKNIF
KLEWGLDSSS VTAEILESVV IPLQSDEAGI SQAEKVDLGS VACARYIDWA VREMLDRGLT
VKDDHRANWW RLLKEFFNSE TGQVLIQRSP KTKDELDQLT SKLGVEGEAI SRIGPELVPL
LTGQTDPLTH FLKDDLLFRV YHSDEGARPN RYIADYAKIL TFQRRDLRIL EIGAGTGGTT
FQILQACSAN GEDFCSEYMY TDISSGFFEA VRTSRLKDWA HLLTFQTLDL EKGAAEQGFK
ENSYDLVIAA NVVHATRSLE KSLSTIHKLL KPGGVLGLVE LTRTTPYINM TFGSIPGWWA
GIDEGRTDSP LQSAEQWNTH LQKTGFSGVD LAAYDLPEPE RHCAMLLSTA LAVNPTTNGH
DTPRVEILDF MSRGLPVHHF SKQVADELSE KGFEASLSGW TTSTVSDSCS YIIMDSAERP
LLTQASNEQF VRITTLLSKA SKVYWISFAD GSNGIIPDNA LMTGFCRTAR NENPNLHCFT
IDVQDSLDQH SDQVRHAITA FIMATEAKIA SHQPREFELM YRNGMMQIQR LVPNEELLKA
VSTNSEDTEI HDTTFHQAER PLKIKVGKIG LLNSLVFVDD DLGDLGPDKV EIQSYAWGLN
FTDVFIALGQ LPPTKPMVGE SAGIVTAVGS NFVSQYKPGD RVAAMFGTPY ASRTRTSGHL
IHHIPDKLSF TDAASLPLTF ATAYYSLYDC ANLQERQTIL IHSASGALGQ AAIKIAQRLG
ATIFATVGSA SKRQLLMEQY GIPKSHIFSS RTTDFVAGIK RLTSGIGMDV VLNSLSGPML
HASWECVAAF GTFIEVGKTD ISRRSQLSME PFENNLRFVS VDLVGLSRQR PAYCQKLLQR
VFADFEAGLV TLLPVTTMPI GDIEKAFRLM QSRTHSGKIV LEADDETTVR ARVQPLQLRA
DGTYIVVGGL GGLGKHLCRH LQVKGARHIA LFSRKTIHGS VKGEIEKELT DVPGAVIRIV
TCDIGHSNTV LRVANELCNT MPPVRGVFHC GMVLSDRTIS QITQQDLEIA LQPKYQGTMN
IYNAFYNTDL DFFINFSSLC GIVGTLGQSN YAAGGAYQDM FSHAQLSLGH SKFVTLDFPL
IKSTYTVTQE HTHSLERQGV QLLPIEAALP VIDYAMSGNA FKDGNHQIAF GLDPQSFINQ
AKQGVKVPPF LSHITSNRGL GLARHSRQEK EQTVEEKIAL ASTTEDAEQL ILIAIRAKIS
SLTALDSQEI DLDPPIANMG LDSLVATEIK NWITNALQAP VQTSDIMDAP SLRSLASFVT
KSSGLVKAKS GSKQERNGNE INGETNGDIQ PSSSGGVTLP KYPLQSLETT LEVFLDSVGH
IGNAEELQHT HKAIDAFQKP GGVGQQLQAR LSKLSGEQGQ NDEVVDMYVR NKWLRGRDWR
PRLRNFFATL PGQDTARCPQ ADQAARLSLT AYEYKLALDK GTVKQDYYNE QALDMATVDW
LFSSNRTPKI GCDRYDRFPK SDYLVVMRHG HAYKVPLRDH NGHTRTYEGL KAIFHVILQQ
TLDGTNWASI FTTANRDEWA KAREVMMTVS QSNYDFVTAI EQALFIVYLE NAAPETADER
ADAFLLDDNS NRWLDKTLSF VVCANGVSAI WGEHTMVDGT TFGGLINALA TPAIEPVQLS
SGPISAHVVA DSDFTYLPFT IPPTHSDYIT TLKAQHRSSH DGYTLANLTH TSYAGAYLRQ
HKLPPKSIIQ LVIQIAVRRL FGHNPLGAVD VISQRLFRGG RTDMIYIMTP PVQAFCAAAE
DPSVSGIQKR RLLLEAVKSH TRLITLSTRG KGFRWHLQAL RELLEPGEEI PVFYKDEIYT
RTSQRPVCTS FTDFGLPEMG RCQPHKSDVW VGVQVFEERV QFTVINGEGS PMPTLVESDP
IMFSSWAEDI GWGSFIKKHC EDARTRVVGS TFYVFRAPTV GVSFFAMEDV SVYHPSNLLY
TQEPLSRYRQ GGYHPVALGD SFDGGRYKVL HKLGWGGFST VWLARDQKGN RWVSIKFMTA
ESGSESQELS NLRALSSSSH EGVAAGYIVQ LLDEFTHKGP NGTHRCLVFE LLGPSVSSIV
EDYHLGGDTL EPEGILRMAE QLLQATSFIH GAGLAHGDIS SRNIAFTCSN LSQCADEESL
FKIVGQPEIA ILARNDGEPL RQGLPNQLVK AADWDEWIDE DEEDIRLLDF GETFAQGAEP
ERIAQPGALR VPETIFTDRF DYRLDLWRVG IAIYSFIFGG LPFQYLGDDD VLVAQMIDFV
EGLPTEWQHK YRDMCFKAGR EPVQDH
//
