ID   A0A094BMD1_9PEZI        Unreviewed;       345 AA.
AC   A0A094BMD1;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
GN   ORFNames=V492_04409 {ECO:0000313|EMBL:KFY11532.1};
OS   Pseudogymnoascus sp. VKM F-4246.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1420902 {ECO:0000313|EMBL:KFY11532.1, ECO:0000313|Proteomes:UP000029299};
RN   [1] {ECO:0000313|EMBL:KFY11532.1, ECO:0000313|Proteomes:UP000029299}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM F-4246 {ECO:0000313|EMBL:KFY11532.1,
RC   ECO:0000313|Proteomes:UP000029299};
RA   Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA   Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA   Ozerskaya S.M.;
RT   "Population genomics of a fungus Geomyces pannorum provides evidence of
RT   horizontal gene transfer but not of sexual reproduction.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. Dihydroflavonol-4-reductase subfamily.
CC       {ECO:0000256|ARBA:ARBA00023445}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFY11532.1}.
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DR   EMBL; JPJU01001458; KFY11532.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A094BMD1; -.
DR   STRING; 1420902.A0A094BMD1; -.
DR   HOGENOM; CLU_007383_9_2_1; -.
DR   Proteomes; UP000029299; Unassembled WGS sequence.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR10366:SF562; ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360); 1.
DR   PANTHER; PTHR10366; NAD DEPENDENT EPIMERASE/DEHYDRATASE; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029299}.
FT   DOMAIN          15..213
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
SQ   SEQUENCE   345 AA;  38148 MW;  929BC0EA0D83E53E CRC64;
     MAQPATNIPK GSWVLVTGAN GFVASHVVQQ FLQRGYKVRG TIRDLEKSSW LIEDAFKSYA
     DSGDFELVVV PDLAATGAFD DAIKGVSAII HAASIINFSP DPNDVIPQTI SGATSILDAA
     LKETSVKAFV YTGSIASAML YDASKSVHVE RDTWNTEAIT FAWAPPPYDP SRGMLVYQAS
     KTEAEMAVWK FHAEKKPHFS VNCVDPSSIM GEALHKKHLE TPYSYLKVLY DGKVGFLEGI
     PSIIHIDVKD VALLHVAAAL DPEVNGARLQ AWAEYCNWND VLAILRRLYP QRKFTDDLPV
     HPPLDVTTDF SQPLALLKKW GDQDGWKTLE ETVADNMKNI VEWYP
//