ID A0A094BT81_9PEZI Unreviewed; 563 AA.
AC A0A094BT81;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 1 {ECO:0000256|RuleBase:RU364059};
DE AltName: Full=Mediator complex subunit 1 {ECO:0000256|RuleBase:RU364059};
DE Flags: Fragment;
GN ORFNames=V491_06349 {ECO:0000313|EMBL:KFY13577.1};
OS Pseudogymnoascus sp. VKM F-3775.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420901 {ECO:0000313|EMBL:KFY13577.1, ECO:0000313|Proteomes:UP000029338};
RN [1] {ECO:0000313|EMBL:KFY13577.1, ECO:0000313|Proteomes:UP000029338}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-3775 {ECO:0000313|EMBL:KFY13577.1,
RC ECO:0000313|Proteomes:UP000029338};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364059}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364059}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 1 family.
CC {ECO:0000256|ARBA:ARBA00006210, ECO:0000256|RuleBase:RU364059}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY13577.1}.
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DR EMBL; JPJT01003943; KFY13577.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094BT81; -.
DR HOGENOM; CLU_008378_1_0_1; -.
DR Proteomes; UP000029338; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR InterPro; IPR019680; Mediator_Med1.
DR PANTHER; PTHR35041; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1; 1.
DR PANTHER; PTHR35041:SF4; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1; 1.
DR Pfam; PF10744; Med1; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU364059};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364059};
KW Reference proteome {ECO:0000313|Proteomes:UP000029338};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364059};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364059}.
FT DOMAIN 17..433
FT /note="Mediator complex subunit Med1"
FT /evidence="ECO:0000259|Pfam:PF10744"
FT REGION 279..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFY13577.1"
SQ SEQUENCE 563 AA; 62263 MW; 9A9C9CD221217084 CRC64;
IGRLDEDERK RRKLIQIVDT LKAVKGRVSE DGIERLARSV GLECLWETGM GRGGKSKTLI
IAGTGLSIDI EFTDNAVETV SLGFPESPES VTRHADQAGK ILLDDLKLNK GETVLTKRVD
RFAGNLDRMA RLDKLSVMPQ LNCHEAITGI FDSLERLHRW EVAKLTEEGA MSGKTQEQIM
RAALLKKSGR PAMNAHGSVG LCLDYWQERQ ATSQGEGCKT WSLLLECDQS SSMVYPPVRV
SSAWISPSVV KSNPTADDVL LSASDVVLDW QDPPNILLPS DPEQKDESDM EGIEQSGQLP
NQKFPDVRFV AKFSPPLTLP YSAAMQIYDS TGAHLEPDAL AAFDALAFPP QIAEPSEPDG
AHRRIRKEQL VSVYSRAGDH EKHCHANTLT IPKMEYALTL TEVPFSHPRE LVQMLPILRQ
YTRLSTLLER SFGSNYTSDH KAESADLPEE STVKDDFDAF MAEASHKDKE LKFAKIPIDI
SLYTQPGPNL RIIFPLGPRI ADILVGIESN GALCVVSQNI LPNGNGMTET TKTKSLTTDD
LGRILETCED IGIFAEFLRQ RLG
//
