ID A0A094C5V9_9PEZI Unreviewed; 1800 AA.
AC A0A094C5V9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=phospholipase A2 {ECO:0000256|ARBA:ARBA00013278};
DE EC=3.1.1.4 {ECO:0000256|ARBA:ARBA00013278};
GN ORFNames=V492_00237 {ECO:0000313|EMBL:KFY17987.1};
OS Pseudogymnoascus sp. VKM F-4246.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420902 {ECO:0000313|EMBL:KFY17987.1, ECO:0000313|Proteomes:UP000029299};
RN [1] {ECO:0000313|EMBL:KFY17987.1, ECO:0000313|Proteomes:UP000029299}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4246 {ECO:0000313|EMBL:KFY17987.1,
RC ECO:0000313|Proteomes:UP000029299};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-
CC glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4;
CC Evidence={ECO:0000256|ARBA:ARBA00023422};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802;
CC Evidence={ECO:0000256|ARBA:ARBA00023422};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY17987.1}.
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DR EMBL; JPJU01000046; KFY17987.1; -; Genomic_DNA.
DR STRING; 1420902.A0A094C5V9; -.
DR HOGENOM; CLU_238109_0_0_1; -.
DR Proteomes; UP000029299; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046486; P:glycerolipid metabolic process; IEA:UniProt.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd07199; Pat17_PNPLA8_PNPLA9_like; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR031352; SesA.
DR PANTHER; PTHR10039; AMELOGENIN; 1.
DR PANTHER; PTHR10039:SF14; NACHT AND TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06670); 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF01734; Patatin; 1.
DR Pfam; PF17107; SesA; 1.
DR SMART; SM00248; ANK; 5.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS51635; PNPLA; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000029299}.
FT DOMAIN 450..665
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
FT REPEAT 1704..1733
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1734..1766
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 34..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1800 AA; 201871 MW; BC62D2C8ED8CEAFD CRC64;
MCLIIWVKRD QFEQERTRIR RKSFNIWERL TSKFASGRDH PPPQYTEETP APSRIRPAPP
SRIISPLHFQ WLRIWEDQTS FVLQYGNRLN NIANALPSPS AQYPSVVLFI GTTSKNKALR
DLYPQNEVST CRKFGIANIC IDSTTADEEH PVLLAESVPD YSQAQPRGKQ KCHETSDHHV
SWPSDECNGP QRQQFINHVH AKLLSLFTDV LCLFAQDYGG LDAVAETLIT WASIGSASSL
EHPIRPRLLI VANIAGNTFA SEALRLQLKV LSHPGFSDSF SSLNVINVLG ASGHAPRGHF
SALEQVLKEE IRLQRAARIN THTLFSMVHI AAFFDLALKN FAKSPLSTFS FLHASRDDFK
VSPNFAQHVR SFMSVLADKK LPGHFAWELI ASAIILDAFP PDMHMFSPSE VFRILYREAC
ALGIQEYLDS QQLSTDLARL VPPTCRIRLF ATDGGGSKGV VTIGFIQKLQ EALDPERPVQ
ENADFSIGTS TGGVINLGLF GKNWTPDQCL TFFCKFAKII FASKTKARLS IWSWISLWSW
VSWIMRISGG RYDVDILEKF LQEAYGTTPM FHTARPSGMK IAVTATTLSD ATLCLISNYY
AEGNPTSNLR YKHLSPTSEK GEILIWEAAR CTSAAPTIFK PKRLHSYGSF QDGGLRNNNP
VRPGQYAVSR KWKDGDCDIV LSIGNGFEQK PLSPVASNFR NLFLDGALSR LYRASMESLS
LNGQNSWDDH WHGLDEETRT NHFRLNLPLE GKEPSIDDID SMDSLYQKTM SHQGDMMEIV
RAFKGVTFFF ELDRALVDDG PFYICYGSIL SRSPDSPRFI RRLISDYPYA QFFNHGTSLG
YITNNDICKL CGLYTKLVAF QVRHSSDQAD IYLKFNRLNH RRISGFPNPI DWFIKRQKLN
AKFGSPNHQS TVIGPRQSDC SCRLQRRRDI PVSLPENRKR PHVVRTRARS KKIRLQETNY
EEFTGSPSPM ADPLTVVGIV ANIIQLVEFT TKVLERLDDF QSNLGEIPKA FRHIRAELPV
LQDALKQTQD KIDYGTIEDS TKAALLPAVQ GCKVQVGALD GLLAETLPVA GDSCLKKTTK
ALWSMTQDSK VESITKTLHG YIATLTFYHA AASSTLQPMK DAKFVEIRRW LSPPDPSINY
RKAIKLRQSD TGLWLLESEV YSKWKRNASP FIWLYGIPGC GKTILSSTVT KDILFYCAND
PGKVVAYFYF DFTDTDKQKP ELMVRSLISQ LSEQCIKMPL SLEALYSSLD KGNRQPSLDA
LMNVLQQMLK EFPQSYLILD ALDECGDRAE LLSILEQMAG WQLEETCVLV TSRKERDIES
SLENIVNRER IICLQSQLVD KDIQTYVRQR LSDDKDLKKW QKEAEIGREI ETTLIDGSRG
MFRWAVCQMD TLGKCRTRSA LQKALKALPT TLDETYERIL CTISDEDSEY AIRILRWLAF
SSRPLSVEEL AEVVAINVER ETVFDRDEVL EDPMEVLDIC MSLVTVVMTE GSSLSEPNGR
LSPITRTVTL AHYSVQEYLV SPRICQRSAA RYSMRPAACH GYIAKGAIGY LLQYEKGLFD
RFESAIALQQ VYTLAQYSAE HWILHTRNGE ENDNQLNYLI AKFLSTGDGA YLNWLRLCDP
DVLWNMPHFR RELDSCPNPL YYTSLGGLTN TAARLVEGGA DVNTQGGFYG NALQASSYGG
HDKIVEVLLS KGGDINAKGG LYGNALQAAS NRGYDKIVEV LLSKGADVNA KGGEYGNALQ
ASSYGGHDKI VEVLLSEGAD VNAKGGEYGN ALQAASAGGH DKIVEVLLSK GAVQVLGNQF
//
