ID A0A094CS50_9PEZI Unreviewed; 831 AA.
AC A0A094CS50;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 08-NOV-2023, entry version 31.
DE RecName: Full=DNA mismatch repair protein S5 domain-containing protein {ECO:0000259|SMART:SM01340};
GN ORFNames=V496_09498 {ECO:0000313|EMBL:KFY50195.1};
OS Pseudogymnoascus sp. VKM F-4515 (FW-2607).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420909 {ECO:0000313|EMBL:KFY50195.1, ECO:0000313|Proteomes:UP000029302};
RN [1] {ECO:0000313|EMBL:KFY50195.1, ECO:0000313|Proteomes:UP000029302}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4515 (FW-2607) {ECO:0000313|Proteomes:UP000029302};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY50195.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JPJY01001870; KFY50195.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094CS50; -.
DR STRING; 1420909.A0A094CS50; -.
DR HOGENOM; CLU_011171_2_0_1; -.
DR OrthoDB; 1369806at2759; -.
DR Proteomes; UP000029302; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF41; MISMATCH REPAIR PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05820)-RELATED; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Reference proteome {ECO:0000313|Proteomes:UP000029302}.
FT DOMAIN 216..364
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 474..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 831 AA; 90635 MW; 2D8E35DA30416DCA CRC64;
MAIQPLPSST TRILGSCQAL TTPSSLVKEL IDNAIDAKAT SIDVIISANT VDKIEVHDNG
HGIAQEDLDS LGRHGYTSKL RNFEELRTVG SSCLGFRGEA LASSVSLGSV TITTRAEGEP
VAFVVKLKDT GGISSKSSVS HPIGTTVCVS NFLSALPVRR QTSISDAPKT ISKIKNILQS
YALARLQVRF TLKVAKTGKG NWSYIPHPKG YIKEAAIQVA GKDVAKQCIE VASPYGGNAS
IFDAIDENGT TKANPFIRIR AFLPSPDSDF SKLKGGHYAS VDSRPVSCMR GTLKRVISSY
KQHIRAFIAK SGKEVPKDSF IYLRITCPIG SYDPNIEPAK DDVLFEDEDA IISVAEELFK
SVYSTNTPVI PEDDTFNGLS ASKPDEGHCS AIQQCVDVSR SVFVADFQTP EANYRTRDNQ
VHKCITVDTL VDNARGREFE KLKDIACEPQ SPPSTLERSD RNDLNPWIIA KLNTPTTECG
PQGSRTLRPK PLRSNILPVD DTPPASSDDL LPCEHLPNRF AGGQIRKQQR PSSTQSSVET
WINRQQTYET DGFAELQHGP EPQQSRHAIG RDSMSQLHSE APYSNGFVTA RALPVDAPWS
PPPTQIRSKE KLPRKFNTPF IAPKKTGVAP GVPGDAYEFS HLTTLGDPLS SPSQGLPRAS
TSAFHDNVDA ALDFERRKVT STKRLREETA DVARLEAKAY DVAMQGMPVQ ETIFKTVLPD
GDPRAYLMRR QKSMTANLKG PHLGPGLKRA KTILLPLESI PNTLGTHNLI LQMSIQTESV
SRAMHLLSSF DNYAKSGTRC EGLRMTDSCA SEVEESLNKL MTASPKHSAL A
//
