ID A0A094CVL4_9PEZI Unreviewed; 1065 AA.
AC A0A094CVL4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=amidase {ECO:0000256|ARBA:ARBA00012922};
DE EC=3.5.1.4 {ECO:0000256|ARBA:ARBA00012922};
DE Flags: Fragment;
GN ORFNames=V491_01245 {ECO:0000313|EMBL:KFY26592.1};
OS Pseudogymnoascus sp. VKM F-3775.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420901 {ECO:0000313|EMBL:KFY26592.1, ECO:0000313|Proteomes:UP000029338};
RN [1] {ECO:0000313|EMBL:KFY26592.1, ECO:0000313|Proteomes:UP000029338}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-3775 {ECO:0000313|EMBL:KFY26592.1,
RC ECO:0000313|Proteomes:UP000029338};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a monocarboxylic acid amide + H2O = a monocarboxylate +
CC NH4(+); Xref=Rhea:RHEA:12020, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:35757, ChEBI:CHEBI:83628; EC=3.5.1.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001311};
CC -!- SIMILARITY: Belongs to the amidase family.
CC {ECO:0000256|ARBA:ARBA00009199}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY26592.1}.
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DR EMBL; JPJT01000654; KFY26592.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094CVL4; -.
DR HOGENOM; CLU_009600_4_1_1; -.
DR Proteomes; UP000029338; Unassembled WGS sequence.
DR GO; GO:0004040; F:amidase activity; IEA:UniProtKB-EC.
DR GO; GO:0043864; F:indoleacetamide hydrolase activity; IEA:UniProtKB-EC.
DR Gene3D; 2.60.120.590; Alpha-ketoglutarate-dependent dioxygenase AlkB-like; 1.
DR Gene3D; 3.90.1300.10; Amidase signature (AS) domain; 1.
DR InterPro; IPR027450; AlkB-like.
DR InterPro; IPR037151; AlkB-like_sf.
DR InterPro; IPR020556; Amidase_CS.
DR InterPro; IPR023631; Amidase_dom.
DR InterPro; IPR036928; AS_sf.
DR PANTHER; PTHR46072:SF7; AMIDASE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR46072; AMIDASE-RELATED-RELATED; 1.
DR Pfam; PF13532; 2OG-FeII_Oxy_2; 1.
DR Pfam; PF01425; Amidase; 1.
DR SUPFAM; SSF75304; Amidase signature (AS) enzymes; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS00571; AMIDASES; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000029338}.
FT DOMAIN 332..477
FT /note="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"
FT /evidence="ECO:0000259|Pfam:PF13532"
FT DOMAIN 574..1051
FT /note="Amidase"
FT /evidence="ECO:0000259|Pfam:PF01425"
FT REGION 162..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFY26592.1"
SQ SEQUENCE 1065 AA; 117016 MW; AAF903EE5BF1B0AE CRC64;
KGSRESEISK LEVTVAVDKE ILGLQIAMQH AVAVAVANTL AQLAHELLYH RVPEAEAAEP
GAGALGERLA APAVADWEGF HVFLQVEVEE LHDEVQFVAI GVHNVEEADD VGVVHLFEEG
DLADGGGGDA FIFGFETDFL EGHNAAAVQE VAGFVNDSIG SWKERTPDET NTPPKRPLLD
AREQPPQFMK DIFKRFQRLP LSDISTDSHI LDFTKDNLPQ GVRLDREISS EDLQSIYRRF
VSDARDFNAP ENQPVYSCEA LPGLLILPSF LPSQVQKELL SRLLHRDLSD PEHQTNVHMF
YDVPYPKGAS TPEGQSKTSS FFSYSPKSKI VFNPKDANVH KPLTISKFME KSLRWVTLGG
QYDWTNKVYP DEAPPAFPTD IKDLLEGIFP EMMAQAAIVN LYSPGDTLSL HRDVSEESDN
GLVSISLGCD CLFVVGLGRD PSDSIVVHLR SGDALLMSRE SRFAWHGVPK ILPSSCPTYL
ASWPAENDTL WISEGGGTAE IPISGEIAQA KRASIRAEIP EKWLLSSIPP VQEQKDVTGK
YIQQFLTERE IEITETDAVG IVAKTTTGAW KAREVTEAFC HRAALAHQLV NCLHEIFFKA
AISDAQKLDD YYAKHNAPIG PLHGLPISLK DQFHVRGVET TMGYVGWIGT FEGVKGTGKE
RVFESEMVRE LRALGAVLYV KTAVPHTLMH GETVNNVIGY CWNPKNRRLV CGGSSGGEGA
LIACRGASIG LGTDIGGSIR VPSAFNGLYG IRPSVGRLPY EGMANAMKGQ NSILSVVGPM
GTSVGGLRLV MKAILSQKPW LYDPAVHEIP WRSEQEEAVL QLIKSSGKNR QLAFGIYRHD
GVVRPLPPVR RAIDIVVKTI EKLGHRVIDW VPPPHHYASE IALKTWIFDG GLDVHQSMGL
AGEPLDPAIS TIYGSEPVRE FQASEIAKVN VQIREYRKQY IDYWNSTAEL TGTGEVADAF
IMPVTPFPAA TPLDYPHYDY CTVVNLLDYP SIAIPVTISS ATLDPADEKF VSLSGSPLDK
KTFDIYDPEV FDGAFVGLQL VGRRLHEERL LALAEMLGDG IEGPK
//
