ID A0A094D7U7_9PEZI Unreviewed; 2499 AA.
AC A0A094D7U7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KFY55585.1};
GN ORFNames=V497_06865 {ECO:0000313|EMBL:KFY55585.1};
OS Pseudogymnoascus sp. VKM F-4516 (FW-969).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420910 {ECO:0000313|EMBL:KFY55585.1, ECO:0000313|Proteomes:UP000029268};
RN [1] {ECO:0000313|EMBL:KFY55585.1, ECO:0000313|Proteomes:UP000029268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4516 (FW-969) {ECO:0000313|Proteomes:UP000029268};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY55585.1}.
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DR EMBL; JPJZ01001146; KFY55585.1; -; Genomic_DNA.
DR STRING; 1420910.A0A094D7U7; -.
DR HOGENOM; CLU_000022_6_0_1; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000029268; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002938; FAD-bd.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR030918; PT_fungal_PKS.
DR InterPro; IPR032088; SAT.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR04532; PT_fungal_PKS; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF15; POLYKETIDE SYNTHASE 16-RELATED; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF01494; FAD_binding_3; 2.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR Pfam; PF16073; SAT; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR PRINTS; PR00420; RNGMNOXGNASE.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000029268};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 364..796
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1664..1738
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1604..1649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1737..1780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1605..1649
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1737..1776
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2499 AA; 270157 MW; 0D1E393200132C6A CRC64;
MTGQVQFVVF GDQAVPYHTE LQKLIVKKES HTLAVFLAEA YHALKREISH LSPSQRTQFP
TPSTLAELLV AHHSSSTPSC ALDSALVCLH QIASFVSYIS ETQNEYPQSS SSAVVGSCVG
LLAATAVSCS QNVVDLLSLG PELVVLAFRL GLLVQTKTNS VASNSEKSTS YSSVVGGVDK
DSAANLIDEY CLAKGLSALS RIYVSAVGHG SITVSGPPTH LRDFCSENSS FKSVNVPVSG
LFHSPHLYAD INVEDLLRTL SPDLRKRVAR LDVLSNSDGQ NIPSKTCEGI LRIALLDILS
KQLRWDLITE SASSKLTQLG ALDARILPFA SGSVQSLAAA IGQSGSRTVN IADTAVRLEQ
ESKRSKIAII GFSGRYPEAE SNEEFWNLLV SGLDVHKEIP KDRFDPWLYY DPTGKGKNTS
GVTKGNFLKN PGLFDARFFG LSPREAEQAD PAQRLAMMTA YESMEMAGFV PDATPSSQRD
RVGVFYGTAS DDYRECNSSQ NIDTYFVPGG SRAFLPARIN YQWRFSGPSF DVDTACSSSL
AAIHIACNSL WRQDCDTAIA GGTNVLTNPD NWAGLDRAHF LSHTGNCNTF DDGADGYCRA
ESVATVLLKR LEDAEMDGDP IFGTILGAYT NHSAEAVSMT RPHSGAQRAI FSRIMTGAGV
DSSDVSYVEM HGTGTQHGDA CEMDSVLSVF APEGTQRNQS LHLGSTKANI GHAESASGAS
SLIKVLLMME KGWIPPHVGI KTRINRNFPT DLAQRNVHIA FKPTRWTRPL DKPQGRRAFV
NNFGAAGGNS SVLLEDAPLP RPTVHDPRPL HMVAVSAKTP TSLKRNIRAL REYLDSNPDV
SVSSLSFTTT ARRIHHGFRA IVSGTSTYDI RNALQIAEAK EGYTSTAAAN TTVGFCFTGQ
GSQYLGMGQQ LLEIPQFRAI VMGLEDILRM QGFQSIIPII DGSCTTPLED LPPATLQLSI
TCLQIALGKF WKSLDVTPQM VIGHSLGEYA ALNIAGVLSD SDTIHLVGTR AKLLEKHCTI
GTHAMLAIKA SLEKVSSLIA PHQGLEIACV NGPEDTVVAG SNGDIEAFTN SLSRVSIKGT
QLKVQFAFHS AQVEPMLEAF RHSCRSVTFK DPAIPMVSPL LGKVITTASE FGLPSVYLSR
HCRETVKFCT ALQASCASGA VTEKMVWVEI GPHPICSNMI KNTVGPGVRA FPSLQRNESQ
WKVFVSTLTS LYTCGLAVNW NEYHSGFKAA LRVLGLPAYQ WELKEYWIPY VHDWCLTKGN
APAQIQQALP APAEEAPQPI FTASVQRIVE ENHSGNDTWI TARSDVKYPD LFAVLNGHRI
NGQPLCPSSA YADMALTLFT RLLEKSSVAD KSDFGVSVCD MAVDKTLLLN GDPSQLIEMK
VSANWSTRTA VFALCSITKE GKITTNHAKC TGTFTKKSEW TAEWKRRAFL VKSRIDHLQK
SIHDDSESSA HLLKPGMFYK LFSSIVEYDD AFKGLREAII RSEDLECSAK VKFNTPVGES
DKWVLSPYWI ESLGQITGFT LNGNDALDSE NQVFINHGWG TMKVLKKLSP EETYRTYIKM
HTEDNTSYAG DLYILDSNEE IIGMYEGVVF NALNRKIFER VLPRPGASSS SSSKKNSVLP
DIPVSSVPSR VSNVETQQQI TEQAPSSQPI PTVVPQLIKE DLGPDISVSI RAMISDEVGV
PTNELKDEDD LVDLGVDSLL ALTMADRIRE EFDVTVPSTA FMGSLTVRDL IQLIAGDSAS
SSGDDSSGPS TPPSTDGLTP ALATSTPPTE QPTPGIWDCN SKGKMLGHDL ASSTPLDFIK
LAPLPLSSPR LEMAPATSVL LQGNPRTASK TLWLVPDGSG LATSYLPLPD IDDTVALYGL
SSPFVKRTEG MSQCPFADLT AAYLTEIRRR QPHGPYFLGG WSAGGICAYD AAQYLIAAGE
EVKRLILIDS PNPIGLQKLP DRLYDDFNRV GVFGSGGTSA KKPPAWLLPH FTGFVDILHS
YEPRPWAGPK PLETWVIWAR DGVADDGSIE IRAGDPPNLK WLLRKRSLED LGPNGWDKLV
GRENITIEVL EEANHFSMVK SPAAKGCSNY MSWRGQGKAA RPAPKSVHGA GPSGLALAAL
LQAHSIHPTI YELRAKPTPA FFAAPCGMLD LHEDSGLKAV RAAGLWDAFQ ATLGDCSEEC
RVLSPSGETL HTDQGELSER PEIARNALTK LLLGAVAPES VKWGSKVQSV RSAKTDAGAT
EVTLDLGEEG SATYDFVVGA DGAWSRVRKM LTDVVPVYTG AQYMAATLRE ATAKFPQLVE
VVGSGTMMAL GGGRGIMSHR GPQDSIRLYI AVKTPLENWA KEVGIAGKTA AEAKGVLLGE
GGEYEKWAPQ LQELLATACD EEARDHPGEA MDILPLYMLP AGSRWDTQTG ATLVGDAAHL
MTPWAGEGVN QALLDALELA GVLGGVGQAE GVVQWQEALE APLRKFEEAM IERTKGEAEK
AARNGEMMLG EHGGQAIADI FKLFEDIAAK GGEFPEGLL
//
