ID A0A094DG90_9PEZI Unreviewed; 3973 AA.
AC A0A094DG90;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Carrier domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=V496_02555 {ECO:0000313|EMBL:KFY65451.1};
OS Pseudogymnoascus sp. VKM F-4515 (FW-2607).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420909 {ECO:0000313|EMBL:KFY65451.1, ECO:0000313|Proteomes:UP000029302};
RN [1] {ECO:0000313|EMBL:KFY65451.1, ECO:0000313|Proteomes:UP000029302}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4515 (FW-2607) {ECO:0000313|Proteomes:UP000029302};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the C-terminal section; belongs to the NRP synthetase
CC family. {ECO:0000256|ARBA:ARBA00029443}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY65451.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JPJY01000396; KFY65451.1; -; Genomic_DNA.
DR STRING; 1420909.A0A094DG90; -.
DR HOGENOM; CLU_000022_37_5_1; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000029302; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd19532; C_PKS-NRPS; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF20; HYBRID PKS-NRPS SYNTHETASE APDA; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000029302};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 6..436
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2383..2461
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3555..3634
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2525..2551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3973 AA; 435552 MW; C5DCB14D0739C11B CRC64;
MDYQQSEPIA IVGSGCRFPG AANSPAALWQ LLENPRDILT EIPKERFDVR GWYHRDGDHH
GTSNVLHSYT LEENLTKFDA NFFGISAGEA ECMDPQQRLL LETVYEALEA GGHTIQSLRG
SDTAVYVGVM GGDHETSLLR DANSLPTYFA TGTSRAILSN RISYFFDWRG PSMTIDTACS
SSMIAVHNAV QALRSNDSRI AIACGSTLLL GPEMYVAESN MHMLSPTGRS RMWDADADGY
ARGDGIATVV LKKLSDALAD GDHIECIIRE TGINQDGRTQ GITVPSSEAQ AALIRRTYAR
AGLDLANPAD RPQFFEAHGT GTKVGDPKEA AAIHSSFGGL VGEPLYVGSI KTVIGHTEGA
AGIAGLLKAS LSLQAGVIPP NLLFNRLNPS IEPFIQGLQV PTHAKPWPAL PKDAVRRASV
NSFGFGGANS HAILESYQAQ IDNASSALVV PATPFVFSAA SNTSLVSSLQ AHLDYLKTNP
VNMRDLAWTL QQRRSTFSHK IAFSAPDVES LIRKIELRLK EYEDKSDANI GIRSSSTPPK
VLGVFTGQGA QWPAMGAELI RSSEFVRRRF QELDDALATL PAADRPTWKI ADQLLLDAKS
SRITEAAFSQ PLCTAVQVVL VDLLRSAGIM PSSVVGHSSG EIGAAYAANF IDARDAIRIA
YYRGLYAKLA GGSTGQKGAM LAVGTSLEDA TEVIELDAFV GRVVVAAHNS PASVTLSGDA
DAIAEIKAVF EEEKKFARLL KVDTAYHSHH MLACGDAYVK ALRACKVEVN QNRDTSVTWY
SSVTGGEVME PTTLLQDLYW RDNMVHRVSF YEAVTAAAQA EKPTLVIEIG PHAALKGPTQ
QNIAETGLNL PYTGVMSRGL NDVEAFADGL GYMWTQFGPG AVDFAAFERF FLDAPQAKLA
TGLPSYRWDQ KTHWQESRIA RRMRGRSDPF HELLGVPHVD NTELERRWSN VLKISEVPWL
TGHKLQGDPV FPAAGYASMA FEAAKSIIGN RPIKLIELRD LVIGKAITFG GESDPAAETL
VTLTDITPSK SNLKTRAAKF SVYSAAIKSA RDLEVNASGT INVIFGEPSM SVLPPIQVDD
SNMAETDSER FYTSLSTIGY EYSDSFRTMA NLKRKLNQAT ALISSFDYGD ESERLMVHPA
LLDVAFQSAI LAYSAPDDGR LWSLHVPTFF ECIRVNPELC ATLPLHSVQL PVRAQLLAPE
ANAVDSIRGN LDILSADGQH AMIQVQGAAV VPISMATVFD DRTVFSYNKL GVTAPDGELA
LGELKPSTKD MELGTFRERL AFFYYRKWIH ELTEADWTKS EWHFQRLRDS INWTLSLVDA
GKHPYIQSEW RNDTQTQIDA LFEAHADSVD CRLVRTVGET LPSAVRRQST MIEHMMKDGL
LDEFYKYGLG FQVYNESLGR MVSQFTHVYP RAKIFEVGAG TGGATKFVLE TIGNTFSSYT
YTDISSGYFE KAAEAFSDWK DKLIFKTFDT ERTPESQDFQ EGTYDLIIAS NVLHATESME
KTLKNVRRLL KPGGYLMLLE ITNNKLAAFT SMFGGISGWW AGCEDGRPYA PTMPLEDWNT
VLRQSGFCGV DSTTPNRDGL AWPFSVISAQ AVDNRVSYLR KPLYRSSNAA QISHLTIIGG
KSLEVAKIAE DIADIAGLSC QSVESFADLI SAQSSVVPGQ TVICLSDLED PMFKSLTPEK
MNALKIILEH SQTLLWVGRD SRDQPYQQAM VGFLRCIIHE MPDLSVQHLD VASGVDGVST
LIMEVALRLH TVSQWEASDA LDQQLLYTKE TELMFQHGSL YAPRLLPDPT RNDRINSQRR
SVVKHASLKS DVISISETGS GLPVLKDVPF FSKGKEGKSA MKTCVSTLSA LGITAGLYLF
VSVGFEISTS NAVIALSSSN SNKSYPVVTI PTDTREDPAD LLSAIAAELL AARILSTVVV
GAKVLVHEPG TGSLGSSLAQ ALGRQASARK FEVIFSTSRA DEDPSWLRLS PWMHSHNIKR
LLPTGVTNFL DLATDDESKE VSALIQEALP GVQYTGSKDL WRATSSGLFQ DQEKLISLLK
NAATAAGQHV SGHKPTELSL SQVTDVKTPL HPATLVDWTA EDTAPVTVDT IDATPLFSAN
KSYLMVGLTG QIGQSLCEWM VRNGARNILL TSRHPSVDQK WLDSFKVYGA KVAVYAMDVT
SKANVIQVVN DIQASYPPIM GVANAAMVLK DTLFSQMSYE QMTDVLRPKI DGTNWLDEIF
YDTPLDFFVC FSSTSSVGGV FGQSNYAAAC SYMTSLVRQR RARGLAGSAF DIGRVAGIGY
IERASQVVQE TFEKYSYMPL SETDLHQMFA ETIFAGIPEM NLEPVISTGI ERVPADRKHL
PPWILYPRLS HYLIDTQATN TVTDSKQTVQ PVREQLIEAT SAEQVLSIIK TCFAAKLQIV
LQLTGEEIDM NVPLVEIGID SLVAVEVRSW FLKELQTDMP VLKILGGGSV SDLAEQASKK
LPAELVPMLG DTATPSITKA EKEKPAQRPL MHQEVSFVAT SASKMERNAS FERPALQHAL
SFAGTATTTE THSRGESIAT PSIATPPSSV GGKSSFSDLG AIAESKELSE FKVLRTEPMS
LSQSRFWLLD LFLEDRTASN VAFQYQLNGN LKVDKLAQAL ELVAMRHESL RTFFVNDVSQ
PDMAVQSVSD TNHVKLEHRT INHVDEAAQE YEIHKRHDFD LGKPQLLRMT LLTLNTTTHF
LLVAYHHIIM DGISLQVLLS DLEIAYKSTP LGPSPMQFPT FSVNQRKALQ AGEMDSELEY
WKDIFHDSPA VLPLLPMAIS SSRVPISAFK SNEVSRRVNP VVGQKVKAVA RMTRSTNFHV
YLTVFRILLA RLADVADLTI GIADANRTDD DITRTIGLFL NLLPLRFKPD EAKTFAASVT
ETRNQAYAAL ANSKLPFDMM LQEFHHVERS STHAPFFQAF FDYKVGVKQI SKFGNCQMNM
QQNNTGETNY DINITVIEDD QGPGIIFETQ ATIYDRHATT LLLESYINLL DAFVNAPTMR
TGEPSLYSQA QIQRALDMGK GPDLLSQWPA TLSSRVEQVA RQNKDAVAVR DGNGTSISYG
ALMSRSQAIA ATLQKSGVDP GSKVIVFQQP SVDWIVSLLA IWRIGCIYVP MDIANPLSRL
AAIVETCQPS MILTDATTSP NVNSLCAGNA LTLNVSNVPA SASAIVPDLS LPAQAAVIIY
TSGSTGTPKG ITVKHKGLRN YIEGSIRMYG METPQTTLQQ STLSFDISLE QIFTGLATGG
SVFMCPLNQR GDPLEITKVM RDEHITYSQA TPSEYLMWLQ YGMSTLRQCS DWKYAIAGGE
RLTNTVANKF AALNLSDVRL INSYGPAEIS CGSSFHEIDY RQGEQGDIPI GSQYPNYSAY
VVDKDLKPLP IGIAGEIVIG GAGVAAGYAN NAALTSTQFV PNPFASAAYV ANGWSKMYRT
GDYGHFREDG SLVFRHRISS DLQVKIRGLR IELGDIESNI VRVGNGAILE AIVTVHGEDY
DFLVAHVVFD TKRDIADKDA FLQNVLQDLP VPRYMVPAMA IPIEHLPLNN HSKVDRKAVK
ALPLPEHIAT PALSGELTDT ETQLFRLWQD VLSTHVTNIS ITPATTFFSV GGNSLLIVRL
QTRIREELSV VVSVFELMNS STLGEMAFKI EESVGVETID WERETAVPFV AIPTPVEPYT
APRNQPKVVV LTGATGFLGR HLLKRLENDP NITEIHCVAV RDKPVVSSPK VSVHHGDLSD
PMLGLSQPEF EDLSLTADVI IHLGAVRSFW DNYHALRQAN VQPIRELVKL AAGRRVPIHF
ISSSGVLPTT DYAPIGDSVA QNQPATDGSN GYVASKWAGE RILEQANADL NIPVSIHRFV
AGGPEPPHDS VTPVMQWLAQ HSEMHKIKPD IAGWRGHIDL LKMDEATEAL CESLVGDSPR
ARFLHHESHV RLRECDMEAF VGLRKGRADL KEMELLDWFG RIKDDGFEYF LSSHMASFQA
GDHNGGNVLT MRR
//
