ID A0A094E5J1_9PEZI Unreviewed; 1260 AA.
AC A0A094E5J1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Pre-mRNA-processing ATP-dependent RNA helicase PRP5 {ECO:0000256|ARBA:ARBA00041162};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE AltName: Full=Pre-mRNA-processing ATP-dependent RNA helicase prp5 {ECO:0000256|ARBA:ARBA00040918};
GN ORFNames=V494_02451 {ECO:0000313|EMBL:KFY42357.1};
OS Pseudogymnoascus sp. VKM F-4513 (FW-928).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420907 {ECO:0000313|EMBL:KFY42357.1, ECO:0000313|Proteomes:UP000029288};
RN [1] {ECO:0000313|EMBL:KFY42357.1, ECO:0000313|Proteomes:UP000029288}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4513 (FW-928) {ECO:0000313|Proteomes:UP000029288};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: ATP-dependent RNA helicase involved spliceosome assembly and
CC in nuclear splicing. Catalyzes an ATP-dependent conformational change
CC of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP
CC association with intron RNA. {ECO:0000256|ARBA:ARBA00037330}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX46/PRP5
CC subfamily. {ECO:0000256|ARBA:ARBA00038511}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY42357.1}.
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DR EMBL; JPJW01000851; KFY42357.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094E5J1; -.
DR STRING; 1420907.A0A094E5J1; -.
DR HOGENOM; CLU_003041_0_3_1; -.
DR OrthoDB; 5477821at2759; -.
DR Proteomes; UP000029288; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR CDD; cd17953; DEADc_DDX46; 1.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR PANTHER; PTHR47958:SF35; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR47958; ATP-DEPENDENT RNA HELICASE DBP3; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000029288}.
FT DOMAIN 627..655
FT /note="DEAD-box RNA helicase Q"
FT /evidence="ECO:0000259|PROSITE:PS51195"
FT DOMAIN 658..836
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 847..1011
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 84..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1016..1068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 627..655
FT /note="Q motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00552"
FT COMPBIAS 96..204
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..411
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..449
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 522..538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1034..1059
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1260 AA; 138130 MW; 568FB5A877CD147C CRC64;
MPGDREAPVV QFKHLPCEFK FMLRHSELLL PGNNNPDTGL IYTALAQQHC YGGSNIVENC
EKLIRDLTTL PKEAEETMIF DTTETAGMTH EGHHGGGAAL GRRHRDARDL PRQRDRSIGR
RDDGYRRRDR SRDRRPSRER YQDRERSPDR RRRRSRDRDY RDRRDDSRDR LHRRHEDHTN
SYSRSRPDDG RDSRTNREPD GKRNAAEQPQ APTGPTDEQK KAERLAKLEA WKKKVAEQKE
QKEKLEAGGT RKLLNEIDVK ANGSPSATPG SPALLNDTAS PGSPAPYAGK FDPKAIAKRA
SEKLNAAAAL GKNTPGIDLA QASATSLPAT NGAPADKTLP AFSSSSKGML HQPTTVSTRL
LIKKTASALP KARGNLSAFG LGAKSAHDQE KSSTKRGLVF GDDEGMRKKL EKLPSLPVAN
TEDDDTAQAN GDEKSDDDDD VDMEADGTEE EAAAAARAAA EQRREERLQA ENNTLADGVA
ADVAMAEAPE VAPEQAAAEE EEEEVDPLDA FMEEMGDPFA APKTTTNFNK SKSKSQQEPE
PIFGDEEDQL GALDSEPEDI LAMASKVRKK KDLPVINYAK LDLAPFRKNF YTEPAELAGM
TEAALADLRL ELDGIKVSGK NVPIPVQKWS QCGLNIQSLD VIKRLGYERP TAIQMQALPA
IMSGRDVIGV AKTGSGKTMA FMLPMFRHIR DQPPLEGSDG PIGLIMTPTR ELATQIHKEA
KPFLKSMNLR AVCAYGGAPI KDQIAELKRG AEIIVCTPGR MIDLLAANSG RVTNLRRVTY
VVLDEADRMF DMGFEPQVMK IFANIRPNRQ TIMFSATMPR IMDALAKKTL NDPVEITVGG
RSVVAPEITQ IVEVREEDDK FIRLLELLGE LYDKDEDART LVFVDRQEKA DDLLKDLMRK
GYPCMSIHGG KDQIDRDSTI DDFKAGVTPI MIATSVAARG LDVKQLKLVV NYDAPNHLED
YVHRAGRTGR AGNTGTAVTF ITEDQEQYSV GISKALEQSG QPVPDRLNEM RKAFRAKVKT
GKSQDSSGFG GKGLERLDQE REAARMRERK THKTEGDDEE EKEEKGDDEI LLKAASTVQS
ATTPAPAAPA QLVGVPKGID LDGKITVHRT ETAAAGSGSK NPLDKVASAI DAINSRLNKT
GQLRSGVPID NKGPDAGAFH ATLEINDFPQ KARWAVTNRT NVAKILEATG TSITTKGSFY
PAGKEVQAGG DPKLYILVEG DTELVVTNAM RELMRLLKEG TMAAAEVDSR APVGGRYTVT
//
