ID A0A094F414_9PEZI Unreviewed; 1099 AA.
AC A0A094F414;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Upf1 domain-containing protein {ECO:0000259|PROSITE:PS51997};
GN ORFNames=V500_08158 {ECO:0000313|EMBL:KFY85736.1};
OS Pseudogymnoascus sp. VKM F-4518 (FW-2643).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420913 {ECO:0000313|EMBL:KFY85736.1, ECO:0000313|Proteomes:UP000029284};
RN [1] {ECO:0000313|EMBL:KFY85736.1, ECO:0000313|Proteomes:UP000029284}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4518 (FW-2643) {ECO:0000313|Proteomes:UP000029284};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00000600};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC Evidence={ECO:0000256|ARBA:ARBA00000600};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY85736.1}.
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DR EMBL; JPKC01002447; KFY85736.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094F414; -.
DR STRING; 1420913.A0A094F414; -.
DR HOGENOM; CLU_001666_4_0_1; -.
DR Proteomes; UP000029284; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR CDD; cd21407; 1B_UPF1-like; 1.
DR CDD; cd18039; DEXXQc_UPF1; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR CDD; cd21400; ZBD_UPF1-like; 1.
DR Gene3D; 2.40.30.230; -; 1.
DR Gene3D; 6.10.140.1240; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR040812; UPF1_1B_dom.
DR InterPro; IPR018999; UPF1_CH/ZBD.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF364; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF18141; UPF1_1B_dom; 1.
DR Pfam; PF09416; UPF1_Zn_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51997; UPF1_CH_RICH; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU01341}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000029284};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU01341};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01341}.
FT DOMAIN 90..247
FT /note="Upf1"
FT /evidence="ECO:0000259|PROSITE:PS51997"
FT REGION 40..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 98..130
FT /note="C3H"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 112..140
FT /note="CC/SHH/C"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 158..188
FT /note="C4"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 910..929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 969..1099
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..1017
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1029..1043
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1099 AA; 120265 MW; 97819DF14A7847EF CRC64;
MEGAFTHLGN HLISDSAAAI NAGDDLSAID PEESLLYGQY GGAGGLGPTR RRNDDDDNET
EVYDDDDVES LASMAVDGMK SLGLRGVEDE KELPAHACAY CGIHSPSSVV KCLGCTKWFC
SARGNASSSH IVNHLVRARH KEVQLHPQST LGDTVLECYN CGTKNVFLLG FIPAKSDTVV
VLLCRQPCAS TPSSKDMSWD ISRWQPLIED RSFLPWLVAV PSDAEQLRAR HLTPPMIAKL
EEMWKDNAAA TIADLEKAAG IDDEPAPVLL KYDDAYQYQN VFGPLVKIEA DYDRKLKEAQ
SEDGLVIRWD YGLNNKHLAS FVLPKIELGD VKLAVGDEMR LKYKGELRPV WEGVGYVVKI
PNNQSDEVTI ELRKIGNDKS VPTECTHNFS ADYVWKATSY DRMQLAMKTF AVDEMSVSGY
IFHKLLGHEV AAAPMKIQMP KKFSVPGLPE LNGSQINAVK SVLQKPLSLI QGPPGTGKTV
TSATVIYHLS KVNGGQVLVC APSNVAVDQL CERIHRTGLK VVRLTAKSRE DVESSVGFLS
LHEQVRMNDS NLELTKLSQL KSELGELSSQ DEKKFKSLTR AAEREILNNA DVICCTCVGA
GDPRLSKMKF RTVLIDESTQ SAEPECMIPL VLGCKQVVLV GDHQQLGPVI MNKKAAKAGL
NQSLFERLVI LGLAPIRLNV QYRMHPCLSE FPSNMFYEGS LQNGVTMQQR LRRDVDFPWP
VGDTPMMFWS NLGNEEISAS GTSYLNRTEA SNVEKIVTRF FKAGVQPADI GVITPYEGQR
SYVVSSMQNT GTFKKENYKE IEVASVDAFQ GREKDFIVLS CVRSNDHQGI GFLSDPRRLN
VALTRAKYGL VILGNPKVLS KHPLWHYLLQ HFKERNCLVE GPLTNLQTSL LQFSRPKTTY
RGPQRYQMSY STGLPSNARP PNGKTGNDYS DAGSMLGYIP DDVSSVHSSA LGGVGVGSAY
PQMFSSFATD NSWPGLDPRN RTNGQKSRNR PAESVTGESV AASEMTDTTS SVLDGKGASQ
GGVSLGPAVH DQKQTSLSQS DRLKRYVESG GRLPDYKTGD AGSVFGGSSL LSGAGRRTLD
DDEKSVSTAF ASQVGGGYD
//
