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Database: UniProt
Entry: A0A094GFA6_9PEZI
LinkDB: A0A094GFA6_9PEZI
Original site: A0A094GFA6_9PEZI 
ID   A0A094GFA6_9PEZI        Unreviewed;       806 AA.
AC   A0A094GFA6;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=tRNA ligase {ECO:0000256|PIRNR:PIRNR019634};
DE            EC=6.5.1.3 {ECO:0000256|PIRNR:PIRNR019634};
GN   ORFNames=V500_01326 {ECO:0000313|EMBL:KFY99668.1};
OS   Pseudogymnoascus sp. VKM F-4518 (FW-2643).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1420913 {ECO:0000313|EMBL:KFY99668.1, ECO:0000313|Proteomes:UP000029284};
RN   [1] {ECO:0000313|EMBL:KFY99668.1, ECO:0000313|Proteomes:UP000029284}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM F-4518 (FW-2643) {ECO:0000313|Proteomes:UP000029284};
RA   Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA   Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA   Ozerskaya S.M.;
RT   "Population genomics of a fungus Geomyces pannorum provides evidence of
RT   horizontal gene transfer but not of sexual reproduction.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC         (ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate.;
CC         EC=6.5.1.3; Evidence={ECO:0000256|PIRNR:PIRNR019634};
CC   -!- SIMILARITY: Belongs to the TRL1 family.
CC       {ECO:0000256|PIRNR:PIRNR019634}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFY99668.1}.
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DR   EMBL; JPKC01000373; KFY99668.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A094GFA6; -.
DR   STRING; 1420913.A0A094GFA6; -.
DR   HOGENOM; CLU_010316_1_0_1; -.
DR   Proteomes; UP000029284; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0051730; F:GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity; IEA:InterPro.
DR   GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
DR   GO; GO:0003972; F:RNA ligase (ATP) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR019039; T4-Rnl1-like_N.
DR   InterPro; IPR012387; Trl1_fun.
DR   InterPro; IPR015966; tRNA_lig_kin_fungi.
DR   InterPro; IPR015965; tRNA_lig_PDEase.
DR   PANTHER; PTHR32004; TRNA LIGASE; 1.
DR   PANTHER; PTHR32004:SF1; TRNA LIGASE; 1.
DR   Pfam; PF09511; RNA_lig_T4_1; 1.
DR   Pfam; PF08302; tRNA_lig_CPD; 1.
DR   Pfam; PF08303; tRNA_lig_kinase; 1.
DR   PIRSF; PIRSF019634; tRNA_lig_yeast; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000256|PIRNR:PIRNR019634};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029284};
KW   tRNA processing {ECO:0000256|PIRNR:PIRNR019634}.
FT   DOMAIN          77..309
FT                   /note="T4 RNA ligase 1-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF09511"
FT   DOMAIN          401..559
FT                   /note="tRNA ligase kinase"
FT                   /evidence="ECO:0000259|Pfam:PF08303"
FT   DOMAIN          562..803
FT                   /note="tRNA ligase phosphodiesterase"
FT                   /evidence="ECO:0000259|Pfam:PF08302"
FT   REGION          606..633
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        128
FT                   /note="N6-AMP-lysine intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR019634-50"
SQ   SEQUENCE   806 AA;  92506 MW;  4EC146E5D2C99E8D CRC64;
     MADQENVPFV AQDIQEIATF LKDLESHAKK WVGVSRSKKT FSCKKNAFDV QNSPDKLVVD
     SWRFQEWDYK RDDLPTYARG LFTYHTKDNR PEIAIRGYDK FFNTDEIEAT KWNNIEQYTK
     GPYELSLKEN GCIIFISGLS DDSLLVCSKH STGPREDANL SHAMAGERWV DRQLKALGKT
     RQDLSRELRK RNATAVAELC DDDFEEHILA YRGDSAGLYL HGININIPEF TTYSGPQVQQ
     FADDWGFKRT DFLVLDDITK VRTFLESVAE TGSYNGRDVE GFVIRCKSNF RSKEYQDWFF
     KYKFEEPYLM FRQWRECTKM MINGKPPLFK KHVKITEEYL LFARKKLAEN PKLAREYNGN
     HGIIELRDDF LKEKNLKGSD LLRLEYSNEG EAPQDATKNI ILVPVATIGC GKTTIAIALQ
     HLFGWGHVQN DNIQGKGRPP RFTKEVMSQL EEKPVVIADR NNAQKHERRQ LIGDVHHQYI
     SSARLVALNF VHDRDSIEKI RQVTMDRVFA RGDNHQTIQA ASDKSKVMGI MQGFINRFEP
     LRADQDPDHG FDAVIDLDPT SDSRQNLETV IARLSDLYPK LFTDMPTSDD LDDAIAFALN
     EYRPELKHDV SGRGPKSKTN QPKQQKPNVP AAPKKKALEY IAVDVPTKQI LDALEKTFAS
     QEDTKSTFFR QLQETRRVQP KFHVTLIHRA SSRQSPEIWD RYKTLFEVHG DEEKPLGDCQ
     VQLERVVWSD RIMAIVVRLV SEGWECVNPV PHITVGTRAD DVKPKESNDL LQQWLQMGSG
     EETGIFEAVI QGVTVDGTVH AVLQKH
//
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