ID A0A094GFA6_9PEZI Unreviewed; 806 AA.
AC A0A094GFA6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=tRNA ligase {ECO:0000256|PIRNR:PIRNR019634};
DE EC=6.5.1.3 {ECO:0000256|PIRNR:PIRNR019634};
GN ORFNames=V500_01326 {ECO:0000313|EMBL:KFY99668.1};
OS Pseudogymnoascus sp. VKM F-4518 (FW-2643).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420913 {ECO:0000313|EMBL:KFY99668.1, ECO:0000313|Proteomes:UP000029284};
RN [1] {ECO:0000313|EMBL:KFY99668.1, ECO:0000313|Proteomes:UP000029284}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4518 (FW-2643) {ECO:0000313|Proteomes:UP000029284};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC (ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate.;
CC EC=6.5.1.3; Evidence={ECO:0000256|PIRNR:PIRNR019634};
CC -!- SIMILARITY: Belongs to the TRL1 family.
CC {ECO:0000256|PIRNR:PIRNR019634}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY99668.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JPKC01000373; KFY99668.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094GFA6; -.
DR STRING; 1420913.A0A094GFA6; -.
DR HOGENOM; CLU_010316_1_0_1; -.
DR Proteomes; UP000029284; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051730; F:GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity; IEA:InterPro.
DR GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
DR GO; GO:0003972; F:RNA ligase (ATP) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR019039; T4-Rnl1-like_N.
DR InterPro; IPR012387; Trl1_fun.
DR InterPro; IPR015966; tRNA_lig_kin_fungi.
DR InterPro; IPR015965; tRNA_lig_PDEase.
DR PANTHER; PTHR32004; TRNA LIGASE; 1.
DR PANTHER; PTHR32004:SF1; TRNA LIGASE; 1.
DR Pfam; PF09511; RNA_lig_T4_1; 1.
DR Pfam; PF08302; tRNA_lig_CPD; 1.
DR Pfam; PF08303; tRNA_lig_kinase; 1.
DR PIRSF; PIRSF019634; tRNA_lig_yeast; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|PIRNR:PIRNR019634};
KW Reference proteome {ECO:0000313|Proteomes:UP000029284};
KW tRNA processing {ECO:0000256|PIRNR:PIRNR019634}.
FT DOMAIN 77..309
FT /note="T4 RNA ligase 1-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF09511"
FT DOMAIN 401..559
FT /note="tRNA ligase kinase"
FT /evidence="ECO:0000259|Pfam:PF08303"
FT DOMAIN 562..803
FT /note="tRNA ligase phosphodiesterase"
FT /evidence="ECO:0000259|Pfam:PF08302"
FT REGION 606..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 128
FT /note="N6-AMP-lysine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR019634-50"
SQ SEQUENCE 806 AA; 92506 MW; 4EC146E5D2C99E8D CRC64;
MADQENVPFV AQDIQEIATF LKDLESHAKK WVGVSRSKKT FSCKKNAFDV QNSPDKLVVD
SWRFQEWDYK RDDLPTYARG LFTYHTKDNR PEIAIRGYDK FFNTDEIEAT KWNNIEQYTK
GPYELSLKEN GCIIFISGLS DDSLLVCSKH STGPREDANL SHAMAGERWV DRQLKALGKT
RQDLSRELRK RNATAVAELC DDDFEEHILA YRGDSAGLYL HGININIPEF TTYSGPQVQQ
FADDWGFKRT DFLVLDDITK VRTFLESVAE TGSYNGRDVE GFVIRCKSNF RSKEYQDWFF
KYKFEEPYLM FRQWRECTKM MINGKPPLFK KHVKITEEYL LFARKKLAEN PKLAREYNGN
HGIIELRDDF LKEKNLKGSD LLRLEYSNEG EAPQDATKNI ILVPVATIGC GKTTIAIALQ
HLFGWGHVQN DNIQGKGRPP RFTKEVMSQL EEKPVVIADR NNAQKHERRQ LIGDVHHQYI
SSARLVALNF VHDRDSIEKI RQVTMDRVFA RGDNHQTIQA ASDKSKVMGI MQGFINRFEP
LRADQDPDHG FDAVIDLDPT SDSRQNLETV IARLSDLYPK LFTDMPTSDD LDDAIAFALN
EYRPELKHDV SGRGPKSKTN QPKQQKPNVP AAPKKKALEY IAVDVPTKQI LDALEKTFAS
QEDTKSTFFR QLQETRRVQP KFHVTLIHRA SSRQSPEIWD RYKTLFEVHG DEEKPLGDCQ
VQLERVVWSD RIMAIVVRLV SEGWECVNPV PHITVGTRAD DVKPKESNDL LQQWLQMGSG
EETGIFEAVI QGVTVDGTVH AVLQKH
//