ID   A0A094H3F5_9PEZI        Unreviewed;       943 AA.
AC   A0A094H3F5;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   22-FEB-2023, entry version 39.
DE   RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN   ORFNames=V499_02108 {ECO:0000313|EMBL:KFY78792.1};
OS   Pseudogymnoascus sp. VKM F-103.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1420912 {ECO:0000313|EMBL:KFY78792.1, ECO:0000313|Proteomes:UP000029295};
RN   [1] {ECO:0000313|EMBL:KFY78792.1, ECO:0000313|Proteomes:UP000029295}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM F-103 {ECO:0000313|EMBL:KFY78792.1,
RC   ECO:0000313|Proteomes:UP000029295};
RA   Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA   Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA   Ozerskaya S.M.;
RT   "Population genomics of a fungus Geomyces pannorum provides evidence of
RT   horizontal gene transfer but not of sexual reproduction.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFY78792.1}.
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DR   EMBL; JPKB01000306; KFY78792.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A094H3F5; -.
DR   HOGENOM; CLU_007879_1_0_1; -.
DR   Proteomes; UP000029295; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd05992; PB1; 1.
DR   CDD; cd13246; PH_Scd1; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR010481; Cdc24/Scd1_N.
DR   InterPro; IPR033511; Cdc24/Scd1_PH_dom.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR000270; PB1_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR47339; CELL DIVISION CONTROL PROTEIN 24; 1.
DR   PANTHER; PTHR47339:SF1; CELL DIVISION CONTROL PROTEIN 24; 1.
DR   Pfam; PF06395; CDC24; 1.
DR   Pfam; PF00564; PB1; 1.
DR   Pfam; PF15411; PH_10; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
FT   DOMAIN          196..371
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          442..464
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          557..576
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          583..806
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          818..838
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        590..621
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        662..691
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        702..739
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        762..794
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        818..834
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   943 AA;  105050 MW;  4CDD2C03A294D159 CRC64;
     MSSSTLTSAS SASLNTLSTT TTLSQNGSNV VATNNIINQR ADASRSLYQI CVSLRQRLLL
     VPGFEQHLQE LDDDEIYDDD PVTSLWRCLR KGYPLMTIYN ALQPPAPLQV DDKVSEAKKP
     KSAASKFVLA CLKDLKLPPE EVFVLNDLFG DDTTGFVKVT QVLNVVLDVA EQRGLLLTPE
     AEAETPNAAV GGKMSYRDHV VRELVDTERK YVQDLENLHE LKKQIEQKGV IPGDVVHAIF
     LNINAILDFQ RRFLIRIETT NSQPDARQEW GAPFVVHEES FGIYQPFIAN QRRAADIAKR
     EFDKISLADH PVVVDFNTLD GFLLKPMQRL VKYPLLLKDL RDKTNADDQT KAELTAGMEA
     SNRVLHQANA AVDRELRNEA LVDLCTRVDD WKNHDINQFG DLLLHGVFTV ITGKSDLEKE
     YTIYLFERIL LCCKEVNPNK ATKDKLMGGG QKDKKAAKDK KDKSGKTIKL QLKGRIFMTN
     VTDVVSMVKP GSYTVQIWWK GDPGIENFMI RFSHEEVMKK WSAAVDKQRK DCLDREKGPE
     VGTPEFAWMQ AQNAPIQNPY AQPEDDDDDD DDYPQLANSG VFAEQAIPPE QSSFGMNRNT
     SSTSLRSRST TGESIQSITG VVRQAPPRFP MGPQPPLSLQ TQMPLQTPPA GARGGDSYFS
     PVAESPASSR TSQNSMFPFP RQGSITGNWE DHNRYTAPAI GRTPSRESQQ SINYRNNPQR
     PSLPVMSSQQ AQMVNAARRR NDSQPVPAVP GIPPHLHPAY DNSIPRSSNV SPINGIPVRS
     ATQSPGTQRE RSQPPQAGYP AVPPAYLRSN TTPVLATVQG GEDRTQTMSP PLNNSLPGMD
     MPLPTQLKVK VNCDGNYVTL VVAFNITYQS LIDRIDAKVG RFSNNAIARG TMRLRYQDED
     GDYVTIESDD DIHIAFQEWR EQQIEGLKNG MLGEIELFCA SIE
//